Biosketch:
Dr. Temesvari completed a BS in Microbiology and Immunology from McGill University (Montreal, Canada) and a Ph.D. in Biological Sciences from the University of Windsor (Windsor, Canada). After completing a post-doctoral fellowship and LSU Health Sciences Center (Shreveport, LA) she joined the faculty at Clemson University

 

Research Summary:
The overall goal of the Temesvari laboratory is to understand the molecular mechanisms regulating a virulence in several pathogenic amoebae, Entamoeba histolytica and Acanthamoeba castellanii. These parasites causes amoebic dysentery and liver abscess) and keratitis, respectively. The Temesvari laboratory focuses on parasite-host interactions, the stress response in the parasite, vesicle trafficking, lipid rafts and drug-repurposing.

 

Selected Publications:
2022 Walters, H.A., Welter, B.H., Moss, H.C., Villano, M.A., Orobio-Hurtado, R., Sullivan, W.J. Jr., Temesvari, L.A. Eukaryotic Initiation Factor 2-alpha Kinases Regulate Virulence Functions, Stage Conversion, and the Stress Response in Entamoeba invadens. mSphere. 7(3):e0013122. doi: 10.1128/msphere.00131-22.

2021 Karambizi, N.U., McMahan, C.S., Blue, C.N., and Temesvari, L.A. Global estimated Disability-Adjusted Life-Years (DALYs) of diarrheal diseases: A systematic analysis of data from 28 years of the global burden of disease study. PLoS One 16(10):e0259077. doi: 10.1371/journal.pone.0259077.

2021 Walters, H.A., Welter, B.H., Orobio-Hurtado, R., Moss, H.C., Villano, M.A., Sullivan, W.J., Jr., and Temesvari, L.A. EiIF2K-A, a eukaryotic initiation factor 2-alpha kinase, regulates virulence functions, stageconversion, and the stress response in Entamoeba invadens. Revising for PLoS Pathogens (IF=6.218)

2020 Welter B.H., Walters H,A, and Temesvari L.A. Reduced expression of a rhomboid protease, EhROM1, correlates with changes in the submembrane distribution and size of the Gal/GalNAc lectin subunits in the human protozoan parasite, Entamoeba histolytica. PLoS ONE 15(3): e0219870. https://doi.org/10.1371/journal.pone.0219870 (IF=2.776)