Clemson scientist Hugo Sanabria receives grant to continue cancer research
Hugo Sanabria has received a National Institutes of Health grant to continue cancer research after his Clemson University School of Health Research (CUSHR) Faculty Fellowship
DNA facilitates heterodimerization between human transcription factors FoxP1 and FoxP2 by increasing their conformational flexibility.
Coñuecar R., Asela I., Rivera M., Galaz-Davison P., González-Higueras J., Hamilton G. L., Engelberger F., Ramírez-Sarmiento C. A., Babul J., Sanabria H., & Medina E. (2023) DNA facilitates heterodimerization between human transcription factors FoxP1 and FoxP2 by increasing their conformational flexibility. iScience 26(7):107228.
Domain tethering impacts dimerization and DNA-mediated allostery in the human transcription factor FoxP1
Cruz P., Paredes N., Asela I., Kolimi N., Molina J. A., Ramirez-Sarmiento C. A., Goutam R., Huang G., Medina E., & Sanabria H. (2023) Domain tethering impacts dimerization and DNA-mediated allostery in the human transcription factor FoxP1. J Chem Phys 158(19).
Coevolution and smFRET Enhances Conformation Sampling and FRET Experimental Design in Tandem PDZ1-2 Proteins
Krishnamohan A., Hamilton G. L., Goutam R., Sanabria H., & Morcos F. (2023) Coevolution and smFRET Enhances Conformation Sampling and FRET Experimental Design in Tandem PDZ1-2 Proteins. J Phys Chem B 127(4):884-898.
Novel approach gives researchers unprecedented view of protein that plays a role in neurological disorders
Two Clemson University groups are among the international team of researchers that developed a novel and technologically advanced approach that offers an unprecedented view of a protein linked to many neurological disorders.
A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories
Gotz M., Barth A., Bohr S. S., Borner R., Chen J., Cordes T., Erie D. A., Gebhardt C., Hadzic M., Hamilton G. L., Hatzakis N. S., Hugel T., Kisley L., Lamb D. C., de Lannoy C., Mahn C., Dunukara D., de Ridder D., Sanabria H., Schimpf J., Seidel C. A. M., Sigel R. K. O.,…
Fuzzy supertertiary interactions within PSD-95 enable ligand binding
Hamilton G. L., Saikia N., Basak S., Welcome F. S., Wu F., Kubiak J., Zhang C., Hao Y., Seidel C. A. M., Ding F., Sanabria H., & Bowen M. E. (2022) Fuzzy supertertiary interactions within PSD-95 enable ligand binding. Elife 11:e77242.
George Hamilton Graduation
Dr. George Hamilton successfully defended his Ph.D. dissertation on March 29, 2022, and graduated this Spring 2022. He starts his new position as a postdoctoral fellow at the laboratory of Dr. Eli Rothenberg at New York University School of Medicine.
Unraveling multi-state molecular dynamics in single-molecule FRET experiments. II. Quantitative analysis of multi-state kinetic networks
Opanasyuk O., Barth A., Peulen T-O., Felekyan S., Kalinin S., Sanabria H., Seidel C.A.M., Unraveling multi-state molecular dynamics in single-molecule FRET experiments. II. Quantitative analysis of multi-state kinetic networks. The Journal of Chemical Physics. 2022;157(3):031501.
Unraveling multi-state molecular dynamics in single-molecule FRET experiments. I. Theory of FRET-lines
Barth A., Opanasyuk O., Peulen T-O., Felekyan S., Kalinin S., Sanabria H., Seidel C.A.M., Unraveling multi-state molecular dynamics in single-molecule FRET experiments. I. Theory of FRET-lines. The Journal of Chemical Physics. 2022;156(14):141501