cchouin – IMMS

Heidi Presents at ASMS Winter Conference on Microbial Sciences

UncategorizedBy cchouin February 2, 2026

Advancing Metabolomic Characterization of Eukaryotic Pathogenic Systems: A Focus on High-Resolution Ion Mobility Separation of Lipid Isomers Heidi M. Sabatini, Christopher D. Chouinard Metabolomics provides a powerful lens for understanding eukaryotic pathogens by revealing small-molecule networks that drive infection, adaptation, and host interactions. These signatures can uncover virulence mechanisms, drug targets, and biomarkers not evident…

Chemistry exhibit at Clemson showcases historic instruments that drive modern innovation

UncategorizedBy cchouin January 5, 2026

Mass spectrometry is a powerful analytical tool that provides detailed molecular information with high sensitivity and specificity. It is essential to modern forensics, pharmaceutical analysis, space exploration and more. A new exhibit highlighting the development of mass spectrometry commissioned by the American Society for Mass Spectrometry will be on display at Clemson University until next…

Agilent 6560 Ion Mobility QTOF LC-MS

InstrumentationBy cchouin February 12, 2025

The Agilent 6560 is a drift tube ion mobility (DTIM)-enabled QTOF system that allows simultaneous measurement of ion mobility/collision cross section (CCS), high resolution accurate mass, and tandem mass spectrometry. The DTIM separates ions based on differences in size, shape, and charge and is primarily used in our lab to rapidly (<60 milliseconds) separate structurally…

Dependency of fentanyl analogue protomer ratios on solvent conditions as measured by ion mobility-mass spectrometry

Analytical Papers, NewsBy cchouin February 11, 2025

Dependency of fentanyl analogue protomer ratios on solvent conditions as measured by ion mobility-mass spectrometry Copeland R. Johnson, Heidi M. Sabatini, Ralph Aderorho, and Christopher D. Chouinard* J. Mass Spectrom. 2024, 59, 8, e5070 Publication Date: July 11, 2024 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10.1002/jms.5070 Recently, our group has shown that fentanyl and many of its analogues form prototropic isomers (“protomers”) during…

SLIM-Based High-Resolution Ion Mobility Reveals New Structural Insights into Isomeric Vitamin D Metabolites and their Isotopologues

Analytical Papers, NewsBy cchouin February 11, 2025

SLIM-Based High-Resolution Ion Mobility Reveals New Structural Insights into Isomeric Vitamin D Metabolites and their Isotopologues Selena Kingsley, Makenna Hoover, Terra Pettit-Bacovin, Anna Rose Sawyer, and Christopher D. Chouinard* J. Amer. Soc. Mass Spectrom. 2024, 35, 11, 2650-2658 Publication Date: May 6, 2024 https://pubs.acs.org/doi/full/10.1021/jasms.4c00116 Testing for vitamin D deficiency remains a high-volume clinical assay, much of which…

Rapid differentiation of xylazine metabolites using SLIM IM-MS

Analytical Papers, NewsBy cchouin February 11, 2025

Rapid differentiation of xylazine metabolites using SLIM IM-MS Ralph Aderorho, Shadrack Wilson Lucas, and Christopher D. Chouinard* Anal. Methods. 2024, 16, 4041-4044 Publication Date: June 5, 2024 https://pubs.rsc.org/en/content/articlehtml/2024/ay/d4ay00801d Xylazine represents an increased threat to the recreational drug market. In this study, we present a rapid strategy for identifying xylazine and differentiating its common isomeric metabolites using Structures…

“Improving Steroid Detection Using Ion Mobility-Mass Spectrometry” – Our Work Featured by Partnership for Clean Competition

UncategorizedBy cchouin February 11, 2025

To gain an unfair advantage over competitors, some athletes may resort to sophisticated performance-enhancing drugs that are marketed as “undetectable” in drug tests. However, recent PCC-funded research may soon put the brakes on this behavior with the introduction of methods for anti-doping testing that can detect designer steroids that were previously very difficult or impossible…

New Instrument! Low Mass MOBIE System Installed

NewsBy cchouin February 11, 2025

This week, MOBILion installed its new low mass-enabled MOBIE system in our lab. Among its technological innovations, this SLIM system includes rounded turns based on recent work that will increase transmission efficiency for low mass ions. We are excited to use it for drug and metabolite studies. Looking forward to the new opportunities this can open…

Mobilion MOBIE SLIM HRIM

InstrumentationBy cchouin February 10, 2025

Shimadzu 8080 Triple Quadrupole LC-MS/MS

InstrumentationBy cchouin February 8, 2025