Research Projects

Research in this group involves ion mobility-mass spectrometry (IM-MS), a powerful technique that provides two separate dimensions of chemical separations information for improving confidence in identification and quantitation in metabolomics, lipidomics, and proteomics. Our projects range from instrument development to biological/clinical applications to fundamental studies of gas-phase chemistry and structure.

TOC figure

IM-MS Measurement of Anabolic Steroids and Other Performance-Enhancing Drugs for Anti-Doping Applications

Mass spectrometry has been the technique of choice in anti-doping labs since the Los Angeles Olympic Games in 1984. Since then, a combination of targeted tandem mass spectrometry and high-resolution techniques have been used to quantify and identify anabolic steroids and other performance-enhancing drugs, respectively. Recently, the promise of ion mobility-mass spectrometry (IM-MS) has been…

Read more
Screenshot 2024 04 08 162738

Chemical Reactions and Noncovalent Complexes as Ion Mobility ‘Shift Reagents’

Where the resolving power of IM-MS techniques is insufficient to differentiate challenging isomers, various chemical approaches have been used to alter their mobility with the goal of better separations. We are primarily focused on simple, fast, and inexpensive reactions targeting common steroid functional groups. Thus far, we have published on reactions with ozone, simple carbonyls…

Read more

Detection of New Psychoactive Substances (NPS) and Other Illicit Drugs

New psychoactive substances (NPS) are a broad class of illicit drugs that pose a significant public health threat. Our group is developing novel ion mobility-mass spectrometry (IM-MS) methods and technology for their detection.   Representative Papers: Separation and Characterization of Synthetic Cannabinoid Metabolite Isomers Using SLIM High-Resolution Ion Mobility-Tandem Mass Spectrometry (HRIM-MS/MS) Improved separation of…

Read more