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Dependency of fentanyl analogue protomer ratios on solvent conditions as measured by ion mobility-mass spectrometry

Analytical Papers, News

Dependency of fentanyl analogue protomer ratios on solvent conditions as measured by ion mobility-mass spectrometry Copeland R. Johnson, Heidi M. Sabatini, Ralph Aderorho, and Christopher D. Chouinard* J. Mass Spectrom. 2024, 59, 8, e5070 Publication Date: July 11, 2024 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10.1002/jms.5070 Recently, our group has shown that fentanyl and many of its analogues form prototropic isomers (“protomers”) during…

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SLIM-Based High-Resolution Ion Mobility Reveals New Structural Insights into Isomeric Vitamin D Metabolites and their Isotopologues

Analytical Papers, News

SLIM-Based High-Resolution Ion Mobility Reveals New Structural Insights into Isomeric Vitamin D Metabolites and their Isotopologues Selena Kingsley, Makenna Hoover, Terra Pettit-Bacovin, Anna Rose Sawyer, and Christopher D. Chouinard* J. Amer. Soc. Mass Spectrom. 2024, 35, 11, 2650-2658 Publication Date: May 6, 2024 https://pubs.acs.org/doi/full/10.1021/jasms.4c00116 Testing for vitamin D deficiency remains a high-volume clinical assay, much of which…

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Rapid differentiation of xylazine metabolites using SLIM IM-MS

Analytical Papers, News

Rapid differentiation of xylazine metabolites using SLIM IM-MS Ralph Aderorho, Shadrack Wilson Lucas, and Christopher D. Chouinard* Anal. Methods. 2024, 16, 4041-4044 Publication Date: June 5, 2024 https://pubs.rsc.org/en/content/articlehtml/2024/ay/d4ay00801d Xylazine represents an increased threat to the recreational drug market. In this study, we present a rapid strategy for identifying xylazine and differentiating its common isomeric metabolites using Structures…

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“Improving Steroid Detection Using Ion Mobility-Mass Spectrometry” – Our Work Featured by Partnership for Clean Competition

Uncategorized

To gain an unfair advantage over competitors, some athletes may resort to sophisticated performance-enhancing drugs that are marketed as “undetectable” in drug tests. However, recent PCC-funded research may soon put the brakes on this behavior with the introduction of methods for anti-doping testing that can detect designer steroids that were previously very difficult or impossible…

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New Instrument! Low Mass MOBIE System Installed

News

This week, MOBILion installed its new low mass-enabled MOBIE system in our lab. Among its technological innovations, this SLIM system includes rounded turns based on recent work that will increase transmission efficiency for low mass ions. We are excited to use it for drug and metabolite studies. Looking forward to the new opportunities this can open…