Dependency of fentanyl analogue protomer ratios on solvent conditions as measured by ion mobility-mass spectrometry Copeland R. Johnson, Heidi M. Sabatini, Ralph Aderorho, and Christopher D. Chouinard* J. Mass Spectrom. 2024, 59, 8, e5070 Publication Date: July 11, 2024 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10.1002/jms.5070 Recently, our group has shown that fentanyl and many of its analogues form prototropic isomers (“protomers”) during…

SLIM-Based High-Resolution Ion Mobility Reveals New Structural Insights into Isomeric Vitamin D Metabolites and their Isotopologues Selena Kingsley, Makenna Hoover, Terra Pettit-Bacovin, Anna Rose Sawyer, and Christopher D. Chouinard* J. Amer. Soc. Mass Spectrom. 2024, 35, 11, 2650-2658 Publication Date: May 6, 2024 https://pubs.acs.org/doi/full/10.1021/jasms.4c00116 Testing for vitamin D deficiency remains a high-volume clinical assay, much of which…

Rapid differentiation of xylazine metabolites using SLIM IM-MS Ralph Aderorho, Shadrack Wilson Lucas, and Christopher D. Chouinard* Anal. Methods. 2024, 16, 4041-4044 Publication Date: June 5, 2024 https://pubs.rsc.org/en/content/articlehtml/2024/ay/d4ay00801d Xylazine represents an increased threat to the recreational drug market. In this study, we present a rapid strategy for identifying xylazine and differentiating its common isomeric metabolites using Structures…

Separation and Characterization of Synthetic Cannabinoid Metabolite Isomers Using SLIM High-Resolution Ion Mobility-Tandem Mass Spectrometry (HRIM-MS/MS) Ralph Aderorho, Shadrack Wilson Lucas, and Christopher D. Chouinard* J. Am. Soc. Mass Spectrom. 2024, 35, 3, 582–589 Publication Date: February 15, 2024 https://doi.org/10.1021/jasms.3c00419 Synthetic cannabinoids, a subclass of new psychoactive substances (NPS), are laboratory-made substances that are chemically similar to…

Determining protonation site in fentanyl protomers using ion mobility-aligned MS/MS fragmentation Ralph Aderorho and Christopher D. Chouinard Int. J. Mass Spectrom. 2024, 496, 117185 Publication Date: December 14, 2023 Drug overdoses in the United States totalled over 100,000 in 2022, with an estimated 68 % of those being attributed to illicitly manufactured fentanyls (IMFs). Their ease and low…

The role of solvation on the conformational landscape of α-synuclein Melanie Cheung See Kit, Tyler C. Cropley, Christian Bleiholder, Christopher D. Chouinard, Frank Sobott, and Ian K. Webb* Analyst. 2024, 149, 125-136. Publication Date: November 17, 2023 Native ion mobility mass spectrometry has been used extensively to characterize ensembles of intrinsically disordered protein (IDP) conformers, but…

Improved analysis of derivatized steroid hormone isomers using ion mobility-mass spectrometry (IM-MS) Shon P. Neal, Walker N. Hodges, Diana C. Velosa, Ralph Aderorho, Shadrack Wilson Lucas, and Christopher D. Chouinard* Anal. Bioanal. Chem. 2023, 415, 6757-6769. Publication Date: September 23, 2023 Over the last decade, applications of ion mobility-mass spectrometry (IM-MS) have exploded due primarily to…

Improved separation of fentanyl isomers using metal cation adducts and high-resolution ion mobility-mass spectrometry Ralph Aderorho, and Christopher D. Chouinard* Drug Test. Anal. 2023, 16(4), 369-379. Publication Date: July 25, 2023 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10.1002/dta.3550 Fentanyl is a potent synthetic opioid that has attracted significant attention due to its illegal production and distribution, resulting in misuse, overdose, and fatalities.…

Development of a Rapid, Targeted LC-IM-MS Method for Anabolic Steroids Ashlee Wedge, Makenna Hoover, Terra Pettit-Bacovin, Ralph Aderorho, Emmaleigh Efird, and Christopher D. Chouinard* J. Am. Soc. Mass Spectrom. 2023, 34, 8, 1708-1714 Publication Date: June 30, 2023 https://doi.org/10.1021/jasms.3c00162 Anabolic steroids are of high biological interest due to their involvement in human development and disease progression.…