J. Gibson Headshot (002)
Graduate Student
Biosketch
I am a second-year PhD student and graduate research assistant in the Cottle Lab at Clemson University’s Bioengineering department. My research entails the elucidation of improving ex vivo gene therapy outcomes for the treatment of inherited metabolic liver diseases. I am currently leading several projects in the lab such as the role of donor age on the engraftment potential and proliferative capacity of transplanted hepatocytes, and the optimization of base-editing as an alternative to CRISPR-Cas9 therapy for liver disease treatments. Recently, I began the position of laboratory manager, guiding budget inspection and order approval as well as fostering research efficiency. I have just begun writing my literature review on the present translatability of gene therapy and am excited to continue along this path to push the frontiers of science.
Research Interests
I presented the poster, Comparison of electroporation systems for CRISPR-Cas9 mediated gene-editing in primary hepatocytes for the correction of hereditary tyrosinemia type 1, in the 2024 SC INBRE Science Symposium. I am also listed as a co-author on the research article, One Shock, Not One Cure: Electroporation Reveals Disease-Specific Constraints in Hepatocyte Gene Editing Therapy and as co-primary author on the peer-reviewed research article, Validation of clinical-grade electroporation systems for CRISPR-Cas9 mediated gene therapy in primary hepatocytes for the correction of inherited metabolic liver disease.