CHG Genomics Core
Our resources support a wide range of applications from single-cell transcriptomics to long-read sequencing and NGS library prep. We are committed to working with you through experimental design to sequencing. We also offer wet lab training courses and seminars to give users hands-on experience. Staffed by experienced scientists, the Genomics Core is fully equipped to meet the evolving needs of modern genomics research.
CHG Genomics Core
Our resources support a wide range of applications from single-cell transcriptomics to long-read sequencing and NGS library prep. We are committed to working with you through experimental design to sequencing. We also offer wet lab training courses and seminars to give users hands-on experience. Staffed by experienced scientists, the Genomics Core is fully equipped to meet the evolving needs of modern genomics research.
Meet the Genomics Core!
Ms. Kaitlyn Williams, M.S. (pictured left) directs the Clemson University Center for Human Genetics Genomics Core. Ms. Sidney Angner (pictured right) serves as the Core’s Genomic Technician. Combined, they hold a total of 10 years of molecular wet lab experience!
Our Core provides comprehensive services for every stage of next-generation sequencing, including extraction, library preparation, and quality control. We are happy to consult with you about your project, and help design your experiment!
Comprehensive Genetic Equipment
PacBio Revio
The Genomics Core offers sequencing services using the PacBio Revio, a high-throughput long-read sequencing platform that delivers highly accurate HiFi reads averaging 15–20 kb with over 90% of bases at Q30+ accuracy. Ideal for applications such as whole-genome sequencing, transcriptome analysis, and structural variant detection, the Revio can generate up to 1.4 terabases of data per day—supporting up to 1,300 human genomes per year at 30× coverage.
Illumina NovaSeq X+
The Genomics Core offers sequencing services using the Illumina NovaSeq X+, a state-of-the-art high-throughput platform capable of generating up to 16 Tb of data in under 48 hours. This system delivers exceptional accuracy, scalability, and cost-efficiency, making it ideal for large-scale projects such as whole-genome, single-cell, and transcriptome sequencing. Let us help power your next big discovery.
ONT PromethION 2 Integrated (P2i)
The Genomics Core offers access to the Oxford Nanopore PromethION 2 Integrated (P2i), a compact benchtop sequencer built for medium-to-high-throughput projects. With two high-output flow cell positions and powerful onboard computing, the P2i enables real-time long-read sequencing of DNA and direct RNA. It supports advanced features like basecalling, methylation detection, demultiplexing, and alignment—ideal for whole-genome sequencing, transcriptomics, and microbiome research.
10X Genomics Chromium iX
Our Genomics Core offers three cutting-edge single-cell sequencing platforms: the 10X Genomics Chromium iX system, Illumina Single Cell equipment, and Parse Biosciences technology, providing versatile options for high-throughput and precise transcriptomic profiling. We use the Countess 3 Fluorescent Cell Counter to accurately assess cell and nuclei concentration and viability, ensuring high-quality samples for all workflows. Together, these state-of-the-art technologies enable comprehensive exploration of cellular heterogeneity with confidence and flexibility.
Fragment Analyzer
We are excited to offer nucleic acid analysis using our in-house Agilent Technologies Fragment Analyzer (12-sample version). This advanced system provides high-resolution sizing and quantification of DNA and RNA, including total RNA, genomic DNA, and NGS libraries. With reliable quality metrics like RQN and GQN, it ensures accurate and consistent sample assessment for your research needs.
Opentrons Flex
The Genomics Core now offers advanced automation capabilities with our in-house Opentrons Flex liquid handling robot. In addition to supporting high-throughput genomics workflows, the Flex is equipped to shear high molecular weight (HMW) DNA—ideal for preparing samples for long-read sequencing. This enables faster, more consistent processing for a wide range of applications.
Our Expertise in Genetics
Comprehensive Genetic Services
DNA, RNA, & High Molecular Weight DNA Extraction
Providing reliable nucleic acid extractions from diverse sample types and organisms in our BSL-2 lab, with expert consultation for user-performed extractions and cell/nuclei isolation.
Whole Genome Sequencing (Short-Read and Long-Read)
Delivering short- and long-read whole genome sequencing with Illumina, PacBio, and ONT, with cost-effective strategies, expert library prep, and consultation support.
RNA Sequencing
Providing expert RNA sequencing with rRNA depletion, polyA enrichment, and advanced long-read options via PacBio Kinnex and ONT Direct RNA.
Single Cell Sequencing
Delivering comprehensive single-cell sequencing—including RNA-seq, ATAC-seq, and Multiome—on cutting-edge platforms like 10x Genomics, Parse, and Illumina, with tailored, cost-effective solutions aligned to your research goals.
Bulk ATACseq
Providing bulk ATAC-seq library preparation with the reliable Zymo-Seq ATAC Kit, delivering high-quality chromatin accessibility profiling and expert support for streamlined, consistent results.
Quality Control
Delivering comprehensive quality control for nucleic acids and sequencing libraries using advanced tools like Nanopore, Qubit, Fragment Analyzer, TapeStation, and KAPA qPCR, ensuring your samples meet the highest standards.
Sequencing
Providing next-generation sequencing on Illumina, PacBio, and ONT platforms, delivering versatile and high-quality data tailored to your research needs.
Consulting
Offering expert consultation for experimental design, nuclei and cell isolation, and all your genomics needs to ensure successful and customized research outcomes.
Connect with Our Experts
Ready to explore how our Genomics core can benefit your research? Reach out today to schedule a consultation with our team and discover the possibilities.
Questions?
For further information about the Clemson Center for Human Genetics please contact us.
or
chg@clemson.edu