Associate Professor, Department of Genetics and Biochemistry
Email: lclark4@clemson.edu
Phone: 864-656-4696
Biosketch
I received my B.S. in Biomedical Sciences from Texas A&M University in 2000. I earned my Ph.D. studying canine genetics and genomics in the laboratory of Dr. Keith Murphy in the College of Veterinary Medicine at Texas A&M University. After graduation, I continued in the laboratory as a Research Assistant Professor in the Department of Veterinary Pathobiology. In 2009, I joined the faculty of Clemson University as an Assistant Professor in the Department of Genetics and Biochemistry.
Research
My laboratory studies canine inherited diseases to 1) improve the health and quality of life for dogs and 2) use the dog as a model to better understand the genetics underlying mammalian hereditary diseases.
Publications
Abrams SR, Hawks AL, Evans JM, Famula TR, Mahaffey M, Johnson GS, Mason JM and Clark LA. 2020. Variants in FtsJ RNA 2′-O-Methyltransferase 3 and Growth Hormone 1 are associated with small body size and a dental anomaly in dogs. Proc Natl Acad Sci USA. 117: 24929-24935. doi: 10.1073/pnas.2009500117.
Tsai KL, Vernau KM, Winger K, Zwueste DM, Sturges BK, Knipe M, Williams DC, Anderson KJ, Evans JM, Guo LT, Clark LA, Shelton GD 2020. Congenital myasthenic syndrome in Golden Retrievers is associated with a novel COLQ mutation. Journal of Veterinary Internal Medicine 34: 258-265.
Tsai KL, Evans JM, Noorai RN, Starr-Moss AN, Clark LA. 2019. Novel Y chromosome retrocopies in canids revealed through a genome-wide association study for sex. Genes 10: 320.
Murphy S, Recio A, de la Fuente C, Shelton GD, Clark LA. 2019. A glycine transporter SLC6A5 frameshift mutation causes startle disease in Spanish greyhounds. Human Genetics 138: 509.
Murphy S, Evans JM, Tsai KL, Clark LA. 2018. Length variations within the Merle retrotransposon of canine PMEL: correlating genotype with phenotype. Mobile DNA 9: 26.
Cox ML, Evans JM, Davis AG, Guo LT, Levy JR, Starr-Moss AN, Salmela E, Hytonen MK, Lohi H, Campbell KP, Clark LA, Shelton GD. 2017. Exome sequencing reveals independent SGCD deletions causing limb girdle muscular dystrophy in Boston terriers. Skeletal Muscle 7: 15.
Evans JM, Noorai RE, Tsai KL, Starr-Moss AN, Hill CM, Anderson KJ, Famula TR, Clark LA. 2017. Beyond the MHC: A canine model of dermatomyositis shows a complex pattern of genetic risk involving novel loci. PLoS Genetics 13: e1006604.
Evans JM, Cox ML, Huska J, Li F, Gaitero L, Guo LT, Casal ML, Granzier HL, Shelton GD, Clark LA. 2016. Exome sequencing reveals a nebulin nonsense mutation in a dog model of nemaline myopathy. Mammalian Genome 27: 495-502.
Link to Google Scholar
https://scholar.google.com/citations?user=DhkKyVUAAAAJ&hl=en&oi=ao