864-889-0519 chg@clemson.edu

Director of the Drosophila Core


Email: nazarioyepiz@hotmail.com


Dr. Nestor Nazario Yepiz

Dr. Nestor Nazario Yepiz

I did my first postdoctoral research (2018-2019) in the Laboratory of Dr. Therese A. Markow in LANGEBIO-CINVESTAV Irapuato (Guanajuato, México). My postdoctoral research project was focus on genomics of metabolism using three ecological diverse species of Drosophila. We evaluated the transcriptional responses of D. arizonae, D. mojavensis and D. melanogaster, two cactophilic and one fruit breeder species respectively, exposed to three isocaloric artificial diets with distinct protein:sugar content. We found more genes that changed their expression in D. mojavensis, the higher specialized species, when comparing the two more extreme diets. The majority of genes that changed their expression encode to enzymes of basal metabolism (carbohydrates and lipids).
My M.Sc. and Ph.D research project was developed in the laboratory of Dr. Juan R. Riesgo in the Institute of Neurobiology at UNAM-Juriquilla (Querétaro, México). My Ph.D. project was focus on Developmental Biology using D. melanogaster as a model system. We characterized the zinc finger protein gene piragua (prg) in the embryonic dorsal closure process, also we found that prg is required during metamorphosis in the thorax-wing formation and eye development.


I want to understand the function of genes related to metabolism in humans using Drosophila as a model system.


Pfeiler E and Nazario-Yepiz NO. 2020. DNA-based taxonomy and potential suppression of long-established names: the case of Telegonus fulgerator (Lepidoptera: Hesperiidae). Syst Biodivers 18: 338–346. doi: 10.1080/14772000.2020.1758825.

Pfeiler E, Nazario-Yepiz NO and Markow TA. 2020. Additional species records and nomenclature updates of butterflies from a threatened coastal habitat in southern Sonora, Mexico. Journal Lepid Soc. 74:197–200. doi: 10.18473/lepi.74i3.a8.

Pfeiler E, Nazario-Yepiz NO, Hernández-Cervantes PL and Markow TA. 2020. Mitochondrial DNA barcodes provide insight into the phylogeography and subspecies controversy in the widespread neotropical White Peacock butterfly, Anartia jatrophae (Nymphalidae: Nymphalinae). Biol J Linn Soc 130: 700–714. doi: 10.1093/biolinnean/blaa080.

Mateus RP, Nazario-Yepiz NO, Ibarra-Laclette E, Ramirez Loustalot-Laclette M, Markow TA. 2019. Developmental and transcriptomal responses to seasonal dietary shifts in the cactophilic Drosophila mojavensis of North America. J Hered 110: 58-67. doi: 10.1093/jhered/esy056.

Vanderlinde T, Guimarães DE, Nazario-Yepiz NO and Carvalho AB. 2019. An improved genome assembly for Drosophila navojoa, the basal species in the mojavensis cluster. J Hered 110: 118-123. doi: 10.1093/jhered/esy059.

Pfeiler E, Nazario-Yepiz NO, Castro-Vargas C and Loustalot-Laclette MR. 2018. DNA barcodes suggest possible new cryptic species in the Codatractus melon species group (Hesperiidae: Eudaminae) in North America. The Journal of the Lepidopterist’s Society, 72(3):203-211.

Nazario-Yepiz NO, Loustalot-Laclette MR, Carpinteyro-Ponce J, Abreu-Goodger C, Markow TA. 2017. Transcriptional responses of ecologically diverse Drosophila species to larval diets differing in relative sugar and protein ratios. PLoS One, 12(8):e0183007. ISSN:1932-6203.

Nazario-Yepiz NO and Riesgo-Escovar JR. 2017. piragua encodes a Zinc Finger Protein required for development in Drosophila. Mechanisms of Development, 144(B):171-181.

Nazario-Yepiz NO, Loustalot-Lacleette MR, Carpinteyro-Ponce J, Abreu- Goodger C and Markow TA. 2017. Drosophila species as models for nutritional studies: development, metabolic pools on diets with contrasting relative sugar:protein ratios. Journal of Nutritional Biology, 3(1):101-107.

Pfeiler E, Nazario-Yepiz NO, Pérez-Gálvez F, Chávez-Mora CA, Loustalot- Laclette MR, Rendón-Salinas E and Markow TA. 2017. Population genetics of overwintering monarch butterflies, Danaus plexippus (Linnaeus), from central Mexico inferred from mitochondrial DNA and microsatellite markers. Journal of Heredity, 108(2):163-175.

Perez-Leaños A, Loustalot-Laclette MR, Nazario-Yepiz NO and Markow TA. 2017. Ectoparasitic mites and their Drosophila hosts. Fly 11(1):10-18.

Sánchez-Flores A, Peñaloza F,Carpinteyro-Ponce J, Nazario-Yepiz NO, Abreu-Goodger C, Machado CA and Markow TA. 2016. Genome evolution in three species of cactophilic Drosophila. G3 (Bethesda), 6(10):3097-3105.

Pfeiler E, Nazario-Yepiz NO, Hernández-Cervantes PL and Markow TA. 2022. Phenotypic diversity, population genetics and interspecific relationships of the Neotropical banded peacock butterfly Anartia fatima (Nymphalidae: Nymphalinae). Biological Journal of the Linnean    Society, 136(1):1–10. https://doi.org/10.1093/biolinnean/blac007

Nazario-Yepiz NO, Fernández-Sobaberas J, Lyman R, Campbell MR, Shankar V, Anholt RRH and Mackay TFC. 2021. Physiological and metabolomic consequences of reduced expression of the Drosophila brummer triglyceride Lipase.PLoS ONE, 16(9): e0255198. https://doi.org/10.1371/journal.pone.0255198

Ranz JM., González PM, Clifton BD, Nazario-Yepiz NO, Hernández-Cervantes PL, Palma-Martínez MJ, Valdivia DI, Jiménez-Kaufman A, Lu MM, Markow TA, Abreu- Goodger C. 2021. A de novo transcriptional atlas in Danaus plexippus reveals variability in dosage compensation across tissues. Commun Biol, 4(791):1–13. https://doi.org/10.1038/s42003-021-02335-3