The Center of Biomedical Research Excellence (COBRE) in Human Genetics constitutes a unique partnership between the Clemson University Center for Human Genetics and the Greenwood Genetic Center (scienceweb.clemson.edu/cobre). Research in the COBRE in Human Genetics focuses on understanding the genetic, genomic, and epigenetic mechanisms by which molecular genetic variation affects rare and common diseases. Investigators of the COBRE in Human Genetics tackle several of the outstanding challenges facing modern human genetics, including the roles of human long non-coding RNAs in risk for human disease, the effects of structural variation on disease phenotypes and gene regulation, development of animal models for rare diseases, and incorporating context-dependent effects into statistical models predicting complex trait phenotypes from large-scale genetic variation data.

The COBRE in Human Genetics will sponsor four Pilot Projects for up to two years each, with annual direct costs of $75,000.

Eligibility: Tenure-track investigators from any Clemson University department (or individuals with an equivalent position at the Greenwood Genetic Center) with research interests in human genetics who have not been a PI on an NIH R01 or equivalent grant are eligible.

Letter of intent: Letters of intent are encouraged but not required. Letters of intent should be received by September 1, 2021 and indicate the name of the applicant and a summary of the intended research proposal (up to 300 words).

Format: Applications should be formatted according to the NIH SF424 application Guide. The applications will consist of a Title, Summary of the Proposed Research (up to 300 words), Specific Aims (1 page), Research Plan (6 pages), Biosketch (including a statement of other support), Budget and Budget Justification. Proposals should note how the project fits thematically into the COBRE in Human Genetics and how completion of the proposed pilot study will position the applicant for a subsequent successful NIH grant application.

Review of applications: Proposals will be reviewed by members of the External Advisory Committee of the COBRE in Human Genetics and the COBRE leadership, using the NIH R01 reviewer template and scoring system. Proposals will be ranked based on the track record of the faculty member, the fit of the proposed research with the theme of the COBRE in Human Genetics, utilization of core facilities, innovation and quality of the proposed research, and the likelihood of the proposed project to be competitive for R01 or equivalent funding when completed. Proposals that meet these criteria, extend the scientific scope of the COBRE in Human Genetics, and are interdisciplinary will be preferred.  Accepted proposals must fully comply with all applicable federal policies, rules, and guidelines for research involving human subjects, vertebrate animals, and/or biohazards before an account is established. Pilot Project Leaders will be required to participate in all professional development activities sponsored by the COBRE in Human Genetics.

Review of progress: Progress reports will be reviewed annually by the External Advisory Committee of the COBRE in Human Genetics and the COBRE leadership.

Application deadline: Applications must be submitted as a single pdf to Dr. Trudy Mackay (tmackay@clemson.edu) by 5:00 pm EST on October 29.

Start date: Results from the reviews of applications will be announced in December, 2021 with a start date of February 1, 2022.

For information contact Drs. Trudy Mackay (tmackay@clemson.edu), Robert Anholt (ranholt@clemson.edu) or Richard Steet (rsteet@ggc.org).

Clemson University invites applications for a tenure-track Assistant Professor as part of a Cluster Hire at the Center for Human Genetics, with an expected start date of August 2022. Clemson University offers competitive salaries, benefits and start-up funds.

The successful applicant will have an accomplished research record at the forefront of human genetics/genomics. Applicants whose research combines experimental laboratory work and computational approaches are especially desirable. Areas of special interest are the mechanisms by which variation in epigenetic modification, gene regulatory networks, chromatin conformation and nuclear architecture affect variation in human health and disease. However, all areas with the potential to significantly advance the field of human genetics will be considered.

The Center for Human Genetics (https://scienceweb.clemson.edu/chg/) is housed in Self Regional Hall, a 17,000-square-foot building located in Greenwood, South Carolina on the Greenwood Genetic Center Partnership Campus. The Center for Human Genetics provides a vibrant interactive research environment with state-of-the-art genomic and computational resources, and is ideally configured for collaborative research. The successful applicant will be part of a collaborative and interdisciplinary environment that includes the research, diagnostic and clinical geneticists at the Greenwood Genetic Center, the genetics, genomics, statistics and bioinformatics faculty at Clemson University, the USC School of Medicine in Greenville and the Prisma Health System. The home department at Clemson will be determined by the fit of the applicant’s research interests with the mission of one of the departments in the College of Science (www.clemson.edu/science), including the Department of Genetics and Biochemistry (www.clemson.edu/science/departments/genetics-biochemistry/index.html), the School of Mathematical and Statistical Sciences (www.clemson.edu/science/departments/mathematical-sciences/index.html) and the Department of Biological Sciences (www.clemson.edu/science/departments/biosci/index.html).

Clemson University is committed to building a diverse and inclusive community of faculty scholars dedicated to working and teaching in a multi-cultural environment (http://www.clemson.edu/inclusion/). We encourage applications from women, minorities and individuals with a commitment to mentoring colleagues and students from demographic groups underrepresented in the sciences. We are also supportive of the needs of dual-career couples.

Successful candidates must hold a doctoral degree and have postdoctoral experience. Competitive candidates will demonstrate an ability to develop a vigorous and independent, externally funded and nationally recognized research program; demonstrate teaching excellence and a commitment to diversity inclusion; and participate in relevant undergraduate and graduate education programs.

Applicants should submit the following items via Interfolio at https://apply.interfolio.com/82505: (1) cover letter; (2) Curriculum Vitae; (3) statement of research interests including future plans; (4) statement of teaching interests and experience; (5) statement describing past experience and/or future plans to promote diversity and inclusion; and (6) up to three reprints in one PDF. Applicants should also arrange, through Interfolio, the submission of three confidential letters of recommendation on their behalf.

Inquiries should be directed to Dr. Trudy Mackay (tmackay@clemson.edu).

For full consideration, applications should be submitted by October 1, 2021. Review will continue until the position is filled.

Clemson University is an AA/EEO employer and does not discriminate against any person or group on the basis of age, color, disability, gender, pregnancy, national origin, race, religion, sexual orientation, veteran status or genetic information. Clemson University is building a culturally diverse faculty and staff committed to working in a multicultural environment.

The Greenwood Genetic Center (www.ggc.org) is a nonprofit institute organized to provide clinical genetic services, diagnostic laboratory testing, educational programs and resources, and research in the field of medical genetics. With a focus on compassionate patient care and innovative scientific advancement, here at the Greenwood Genetic Center, we keep every patient and their families at the forefront of everything we do. Our researchers collaborate with GGC clinicians and laboratory faculty, as well as with colleagues around the world, to achieve significant advances in identifying causative genes, understanding disease mechanisms, and developing treatment and prevention strategies for genetic conditions. The Research Division maintains a state-of-the-art aquaculture facility and an Olympus FV3000 confocal microscope, along with extensive research space. Faculty development at the GGC is currently supported by an NIH COBRE grant in Human Genetics shared between the Greenwood Genetic Center and the Clemson Center for Human Genetics (https://scienceweb.clemson.edu/chg/) on the Greenwood campus. The grant offers mentorship opportunities and pilot project funding to new faculty, with the ability to become a Project Leader and obtain substantial research support for the development of an independent research program.

Job Description:

Assistant Research Scientist in Human Genetics
This is a full-time faculty position in the Research Division at GGC, with primary responsibilities in independent research and functional analysis of genetic variants identified in our patient population. Outstanding opportunities exist for collaboration with basic, translational and clinical investigators. Successful candidates will have track records of creativity and productivity, a desire to integrate into our exciting, collaborative, and growing community of researchers, and a dedication to contribute to our values of diversity and openness. They will be expected to mount a productive and innovative research program, to obtain outside funding, and to participate actively in graduate and post-graduate teaching, training and mentorship.

The specific areas of research interests we are seeking to recruit are: 1) transcriptional regulation; 2) RNA biology and human disorders involving RNA-related genes; 3) chromatin remodeling and epigenetics; 4) neurobiology and the mechanisms underlying neurodevelopmental disorders.
Please contact GGC Director of Research, Dr. Richard Steet (rsteet@ggc.org) directly if interested to learn more about the application process and the position.

Requirements:

Minimum Position Requirements (including years of experience, certifications, licenses, etc.):
• PhD in Genetics, Biochemistry, Molecular/Developmental Biology, or relevant biological field from a college or university of recognized standing.
• Experience in modern genetics, bioinformatics and molecular biology techniques.
• Must have demonstrated scholarly achievement with a record of publications in peer-reviewed journals.
• Must have demonstrated the ability to obtain extramural funding.
• Experience or expertise with zebrafish as a model organism is preferred.

Knowledge, Skills, and Abilities:
• Excellent oral and written communication skills
• Ability to work in a collaborative and multidisciplinary environment

Essential Duties and Responsibilities:
• Development of a robust, externally-supported research program
• Ability to perform functional studies on genetic variants within their area of expertise
• Participate in professional organizations and in internal case conferences and committees.
• Advise trainees and provide career guidance.
• Support and foster interdisciplinary efforts between GGC divisions, and between the GGC and the Clemson Center for Human Genetics.

Additional Information:
SALARY: A full time (12 month) salary is being offered for this position. The final salary will be based on rank and experience of the successful candidate.
CLOSING DATE: September 30, 2021
The Greenwood Genetic Center is an Equal Opportunity/Affirmative Action Employer
The Greenwood Genetic Center encourages applications for employment from persons who are members of groups that have been underrepresented based on race, color, national origin, gender, age, or disability.

Application Instructions:
Please submit the following documents to Kathleen Crowder (kcrowder@ggc.org); letters of support will only be requested for applicants who are invited to interview for the position.
• Cover letter
• Full Resume/CV
• Research Accomplishments and Interests (5 page limit)

The Clemson University Center for Human Genetics and the Greenwood Genetic Center have been awarded a five year Phase I Center of Biomedical Research Excellence (COBRE) in Human Genetics grant to understand the genetic, genomic, and epigenetic mechanisms by which molecular genetic variation affects transcriptional and other molecular networks in health and disease. The Research Core of the COBRE in Human Genetics is seeking a Bioinformatician to support the bioinformatics research of Research and Pilot Project Leaders and their laboratories. The ideal candidate will have a Ph.D. degree with a record of productivity and expertise in analysis of data from high-throughput DNA and RNA sequencing experiments, population genomics, and related areas. The position requires excellent interpersonal, organizational and communication skills.

Please apply for Job ID 105803 at: Clemson Jobs

Applications should include a cover letter explaining the qualifications for this position and the names of three references. The position is available immediately. The salary is competitive and commensurate with credentials and experience. Clemson University is an equal opportunity employer.

Please direct inquiries to Dr. Trudy F. C. Mackay, Self Family Endowed Professor and Director of the Center for Human Genetics, Clemson University, Self Regional Hall, 114 Gregor Mendel Circle, Greenwood, SC 29646 (tmackay@clemson.edu).

The Clemson University Center for Human Genetics and the Greenwood Genetic Center have been awarded a five year Phase I COBRE in Human Genetics grant to understand the genetic, genomic, and epigenetic mechanisms by which molecular genetic variation affects transcriptional and other molecular networks in health and disease. Several positions are available immediately.

• Project 3 (Transposable Elements, Genome Architecture and Gene Regulation) is seeking a Computational Scientist. Contact Dr. Miriam Konkel (mkonkel@clemson.edu) for details.
• Project 4 (Genomic Prediction of Human Disease) is seeking a Postdoctoral Fellow. Contact Dr. Fabio Morgante (fabiom@clemson.edu) for details.

Doctoral Degrees offered:

Biochemistry, Biological Sciences, Environmental Toxicology, Genetics, and Mathematical and Statistical Sciences

Deadline for Doctoral Applications:

Genetics and Biochemistry: December 15th for fall admission and September 1st for spring admission
Mathematical and Statistical Sciences: January 15th for fall admission and October 1st for spring admission
Biological Sciences and Environmental Toxicology: December 10th for fall or spring admission

Active Research Programs through the CHG include**:

• Investigating the roles of gene regulation, post-translational modification and structural variation in common and rare diseases
• Developing more powerful models for genotype-phenotype prediction
• Utilizing systems genetics approaches in cellular and animal models to more fully understand the genome-wide impact of genetic variants on molecular networks in health and disease in human populations

**If a student chooses to pursue a degree while at the Center for Human Genetics, he or she will earn a degree in the department of the mentoring professor.

Prospective graduate students of the College of Science can visit the website for more detailed information about each program.

General Inquiries:

College of Science
118 Long Hall
Clemson, SC 29634
science@clemson.edu
(864) 656-3015