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Keynote speaker: Dr. Marc Porter, University of Utah
Immunoassays and Disease Diagnostics: It’s Not Just About Limits of Detection
The drive for early disease detection, the growing threat of bioterrorism, and the need for safe and secure food and water supplies have amplified the demand for ultrasensitive, high-speed diagnostic tests. This presentation will describe our efforts to develop platforms and readout methodologies that potentially address these needs by coupling nanometric-labeling concepts based on surface-enhanced Raman scattering (SERS) and giant magnetoresistance (GMR) readout. It will focus on the impact of what are often called preanalytics, or the handling and preparation of patient and other types of specimens, on the clinical utility of the measurement. Findings that point to the importance of sample pretreatment with respect to the exacting measurement of biomarkers for tuberculosis diagnostics, and pathogens like Salmonella spp, anthrax, and E. Coli O157-H7 will be examined. Possible implications of these results will also be discussed.
