Postdoctoral Fellow
Email: anuragc@clemson.edu
Biosketch
Dr. Anurag Chaturvedi is a Postdoctoral fellow in the Mackay-Anholt lab at Clemson University’s Center for Human Genetics (CHG). He obtained his PhD (2017) from KU Leuven, Belgium with a focus on “Evolutionary genomics” where he discovered many facets of contemporary evolution in space and time using population genomics. Subsequently, he pursued a Postdoctoral position (2017-2021) at the Université de Lausanne, where his focus shifted towards studying epigenetic mechanisms governing nutrient transport in Mycorrhizal fungi. Subsequently, he received the prestigious Marie Skłodowska-Curie Individual Research Fellowship from the EU H2020 program to work at the School of Biosciences, the University of Birmingham in the United Kingdom.
His research endeavors encompass a diverse range of model organisms, including vertebrates, invertebrates, and microorganisms. By harnessing the power of multi-omics data, his current research focuses on discovering the molecular underpinning of toxic chemicals using Precision Toxicogenetics and Toxicogenomics. Furthermore, he is passionate about teaching and employing educational best practices, to adopt a project-based approach that promotes student success.
Research
One of the biggest challenges in toxicological sciences is the lack of fundamental understanding of the molecular mechanistic framework that can promote evidence-based chemical testing. Dr. Chaturvedi’s research at CHG is focused on the discovery of molecular biomarkers for both natural and manmade Chemicals using next-generation high-throughput sequencing and metabolomics. Specifically, he is working at the forefront of the development of New Approach Methodologies (NAMs) by integrating obtained multidimensional data to decipher adverse outcome pathways using Drosophila as a model system. CHG hosts excellent research facilities including the Drosophila Genetic Reference Panel (DGRP) which serves as a starting point for disentangling:
- Genetic basis of susceptibility to toxic chemicals.
- Discovery of molecular pathways implicated in toxic response leading to adverse outcomes.
Publications
Chaturvedi A, Dhandapani V, Li X, Marshall M, Kissane S, Cuenca-Cambronero M, Asole G, Calvet F, Ruiz-Romero M, Marangio P, Guigó R, Rago D, Mirbahai L, Eastwood N, Colbourne JK, Orsini L (2023) The hologenome of Daphnia magna reveals possible DNA methylation and microbiome-mediated evolution of the host genome Nucleic Acids Research; [PMID: 37638757]
Irimia RE, Montesinos D, Chaturvedi A, Sanders I, Hierro JL, Sotes G, Cavieres LA, Eren Ö, Lortie CJ, French K, Brennan AC (2023) Trait evolution during a rapid weed invasion despite little global genetic differentiation Evolutionary applications 00:1–15; [PMID: 37216028]
The PrecisionTox Consortium (2023) The Precision Toxicology initiative, Toxicology Letters, 383, 33-42; [PMID: 37211341]
Abdullahi M, Zhou J, Dandhapani V, Chaturvedi A, Orsini L. (2022) Historical exposure to chemicals reduces tolerance to novel chemical stress in Daphnia (waterflea). Molecular Ecology, 00, 1– 14; [PMID: 35377519].
Chaturvedi A#, Zhou A, Raeymaekers J.A.M, Czypionka T, Orsini L, Jackson C.E, Spanier K.I., Shaw J.R, Colbourne J.K., De Meester L. (2021). Extensive standing genetic variation from a small number of founders enables rapid adaptation in Daphnia. Nature Communications 12, 4306. [PMID: 34262034].
Chaturvedi A, Corella J.C., Robbins C, Loha A, Menin L, Gasilova N, Masclaux F.G., Lee S.J., Sanders I.R. (2021). The methylome of the model arbuscular mycorrhizal fungus, Rhizophagus irregularis, shares characteristics with early diverging fungi and Dikarya. Communications Biology 4, 901; [PMID: 34294866].
Reddy H.M., Bhattacharya R., Tiwari S., Mishra K, Annapurna P, Jehan Z, Praveena N.M., Alex J.L., Dhople V.M., Singh L, Sivaramakrishnan M, Chaturvedi A, Rangaraj N, Shiju T.M., Sreedevi B, Kumar S., Dereddi S.R., Rayabandla S.M., Jesudasan J.A. (2021). Y chromosomal noncoding RNAs regulate autosomal gene expression via piRNAs in mouse testis.BMC Biology 19, 198; [PMID: 34503492].
Bal T.M.P, Llanos-Garrido A, Chaturvedi A, Verdonck I, Hellemans B, Raeymaekers J.A.M. (2021). Adaptive Divergence under Gene Flow along an Environmental Gradient in Two Coexisting Stickleback Species. Genes 12(3), 435; [PMID: 34503492]
Huyse T, Boon NAM, Van den Broeck F, Mbow M, Chaturvedi A, Meurs L, Volckaert FAM, Polman K. (2018) Evolutionary epidemiology of schistosomiasis: linking parasite genetics with disease phenotype in humans. International Journal of Parasitology 48(2):107-115; [PMID: 29154994].
Raeymaekers JAM*, Chaturvedi A*, Hablützel PI, Verdonck I, Hellemans B, Maes GE, De Meester L, Volckaert FAM. (2017) Adaptive and non-adaptive divergence in a common landscape. Nature Communications 8(1), 267; [PMID: 28814718].
Kokko H, Chaturvedi A., Croll D., Fischer M. C., Guillaume F., Karrenberg S., Kerr B., Rolshausen G., Stapley J. (2017) Can Evolution Supply What Ecology Demands? Trends in Ecology & Evolution, 32(3), 187-197; [PMID: 28087070].
Orsini L., Marshall H., Cuenca Cambronero M., Chaturvedi A.,Thomas K. W., Pfrender M. E., Spanier K. I. and De Meester L. (2016)Temporal genetic stability in natural populations of the waterflea Daphnia magna in response to strong selection pressure. Molecular Ecology 25(24), 6024-6038; [PMID: 27862502].
Muñoz J*, Chaturvedi A*, De meester L, and Weider LJ. (2016) Characterization of genome-wide SNPs for the water flea Daphnia pulicariagenerated by genotyping-by-sequencing (GBS). Scientific Reports 6, 28569; [PMID: 27346179].
Orsini L, Gilbert D, Podicheti R, Jansen M, Brown JB, Solari OS, Spanier KI, Colbourne JK, Rush D, Decaestecker E, Asselman J, De Schamphelaere KA, Ebert D, Haag CR, Kvist J, Laforsch C, Petrusek A, Beckerman AP, Little TJ, Chaturvedi A, Pfrender ME, De Meester L, Frilander MJ. (2016). Daphnia magna transcriptome by RNA-Seq across 12 environmental stressors, Scientific Data, 160030; [PMID: 27164179].
Routtu J, Hall DM, Albere B, Beisel C, Bergeron DR, Chaturvedi A, Choi J, Colbourne J, De Meester L, Stephens T M, Stelzer Claus-Peter, Solorzano E, Thomas K W, Pfrender E M, Ebert D. (2014). An SNP-based second-generation genetic map of Daphnia magna and its application to QTL analysis of phenotypic traits. BMC Genomics, 15:1033; [PMID: 25431334].
Chaturvedi A#, Raeymaekers JAM & Volckaert FAM (2014). Computational identification of miRNAs, their targets and functions in three-spined stickleback (Gasterosteus aculeatus). Molecular Ecology Resources, 14(4), 768-777; [PMID: 24400739].
Chaturvedi A, Tiwari S, Jesudasan RA. (2011) RiDs db: Repeats in diseases database, Bioinformation, 2011;7(2):96-7; [PMID: 35377519]
* These authors contributed equally to this work; # Corresponding author
Dr. Chaturvedi’s research in popular media
https://www.upi.com/Science_News/2021/07/14/britain-water-fleas-rapid-evolution/3421626287486/
https://www.molecularecologist.com/2017/03/27/small-molecules-big-differences/