{"id":14037,"date":"2025-04-25T02:06:57","date_gmt":"2025-04-25T02:06:57","guid":{"rendered":"https:\/\/scienceweb.clemson.edu\/uacl-new\/?p=14037"},"modified":"2025-11-06T02:24:29","modified_gmt":"2025-11-06T02:24:29","slug":"activity-of-nades-at-the-multiomic-level","status":"publish","type":"post","link":"https:\/\/scienceweb.clemson.edu\/uacl\/activity-of-nades-at-the-multiomic-level\/","title":{"rendered":"Activity of NADES at the Multiomic Level"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"14037\" class=\"elementor elementor-14037\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2d2c5ff e-flex e-con-boxed mk-enable-fade-animation-none mk-sticky-column-false mk-sticky-column-disable-tablet e-con e-parent\" data-id=\"2d2c5ff\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_sticky&quot;:&quot;false&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-1425ccd e-con-full e-flex mk-enable-fade-animation-none mk-sticky-column-false mk-sticky-column-disable-tablet e-con e-child\" data-id=\"1425ccd\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_sticky&quot;:&quot;false&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-74c3759 mk-enable-fade-animation-none elementor-widget elementor-widget-theme-post-featured-image elementor-widget-image\" data-id=\"74c3759\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_infinite&quot;:&quot;false&quot;,&quot;mk_ext_is_scrollme&quot;:&quot;false&quot;}\" data-widget_type=\"theme-post-featured-image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"750\" height=\"775\" src=\"https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/REU_project_07.png\" class=\"attachment-large size-large wp-image-14106\" alt=\"REU project 07\" srcset=\"https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/REU_project_07.png 750w, https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/REU_project_07-290x300.png 290w\" sizes=\"(max-width: 750px) 100vw, 750px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c2d6574 e-con-full e-flex mk-enable-fade-animation-none mk-sticky-column-false mk-sticky-column-disable-tablet e-con e-child\" data-id=\"c2d6574\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_sticky&quot;:&quot;false&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-624f78f mk-enable-fade-animation-none elementor-widget elementor-widget-text-editor\" data-id=\"624f78f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_infinite&quot;:&quot;false&quot;,&quot;mk_ext_is_scrollme&quot;:&quot;false&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000\">Due to improved biocompatibility, natural deep eutectic solvents (NADES) are increasingly explored in biomedicine.<sup>93<\/sup> Yet, our understanding of how they interact with biomolecules at multiomic levels- metabolome, proteome, epigenome, and transcriptome &#8211; remains poor. Recently, Agatemor\u2019s group found that a NADES designed from choline and geranic acid (CAGE) upregulates indole-3-lactic acid and 4-hydroxyphenyllactic acid at the metabolomic level, resulting in ligand-independent activation of aryl hydrocarbon receptor to signal the transcription of genes at the transcriptomic level.<sup>92<\/sup> Such metabolic-transcriptomic biochemical crosstalk has important implications for metabolic regulation\/engineering of inflammation, immune response, cell reprogramming, and chemical detoxification.<sup>94<\/sup> This finding prompted new questions on what structural details of the NADES trigger this crosstalk. Elucidating these details will likely pave a scientific foundation to design biocompatible NADES for the metabolic engineering of human cells to regulate inflammation, immune response, cell reprogramming, and chemical detoxification. For this REU, students working in the Agatemor Research Group will participate and be trained in high-throughput synthesis and biochemical screening to uncouple the structure-activity relationship of NADES with a focus on activating aryl hydrocarbon receptors. The training includes LC-MS\/MS proteomic and metabolomic analyses as well as Illumina platform-based mRNA sequencing and bioinformatic analysis of multiomic data. At the end of the research experience, the student will be primed on the skillset required to pursue a STEM career in chemistry and biology.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fe5cc50 e-flex e-con-boxed mk-enable-fade-animation-none mk-sticky-column-false mk-sticky-column-disable-tablet e-con e-parent\" data-id=\"fe5cc50\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_sticky&quot;:&quot;false&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f16a874 mk-enable-fade-animation-none elementor-widget elementor-widget-spacer\" data-id=\"f16a874\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_infinite&quot;:&quot;false&quot;,&quot;mk_ext_is_scrollme&quot;:&quot;false&quot;}\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ad88fbe e-flex e-con-boxed mk-enable-fade-animation-none mk-sticky-column-false mk-sticky-column-disable-tablet e-con e-parent\" data-id=\"ad88fbe\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_sticky&quot;:&quot;false&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f5c9519 e-con-full e-flex mk-enable-fade-animation-none mk-sticky-column-false mk-sticky-column-disable-tablet e-con e-child\" data-id=\"f5c9519\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_sticky&quot;:&quot;false&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fb7c926 mk-enable-fade-animation-none elementor-widget elementor-widget-image\" data-id=\"fb7c926\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_infinite&quot;:&quot;false&quot;,&quot;mk_ext_is_scrollme&quot;:&quot;false&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"767\" height=\"1024\" data-src=\"https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/11\/Christian_Agatemor-767x1024.jpg\" class=\"attachment-large size-large wp-image-14737 lazyload\" alt=\"Christian Agatemor\" data-srcset=\"https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/11\/Christian_Agatemor-767x1024.jpg 767w, https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/11\/Christian_Agatemor-225x300.jpg 225w, https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/11\/Christian_Agatemor-768x1025.jpg 768w, https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/11\/Christian_Agatemor.jpg 899w\" data-sizes=\"(max-width: 767px) 100vw, 767px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 767px; --smush-placeholder-aspect-ratio: 767\/1024;\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b36ed3b e-con-full e-flex mk-enable-fade-animation-none mk-sticky-column-false mk-sticky-column-disable-tablet e-con e-child\" data-id=\"b36ed3b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_sticky&quot;:&quot;false&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-edd9f21 mk-enable-fade-animation-none elementor-widget elementor-widget-text-editor\" data-id=\"edd9f21\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_infinite&quot;:&quot;false&quot;,&quot;mk_ext_is_scrollme&quot;:&quot;false&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000\"><strong>Students working in this project will be mentored by Dr. Christian Agatemor, Bucknell University<\/strong><\/span><\/p><p><span style=\"color: #000000\"><a style=\"color: #000000\" href=\"https:\/\/www.munolab.org\/\"><img decoding=\"async\" class=\"size-full wp-image-14115 lazyload\" title=\"icons8 website\" data-src=\"https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/icons8-website.gif\" alt=\"icons8 website\" width=\"50\" height=\"50\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 50px; --smush-placeholder-aspect-ratio: 50\/50;\" \/><\/a> <a style=\"color: #000000\" href=\"https:\/\/scholar.google.ca\/citations?user=OhXtQNQAAAAJ&amp;hl=en\"><img decoding=\"async\" class=\"size-full wp-image-14116 lazyload\" title=\"icons8 google scholar 50\" data-src=\"https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/icons8-google-scholar-50.png\" alt=\"icons8 google scholar 50\" width=\"50\" height=\"50\" data-srcset=\"https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/icons8-google-scholar-50.png 50w, https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/elementor\/thumbs\/icons8-google-scholar-50-r53orhp59nh1i1yl0nelevkoz1i2lwo3xev7el2dy6.png 35w\" data-sizes=\"(max-width: 50px) 100vw, 50px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 50px; --smush-placeholder-aspect-ratio: 50\/50;\" \/><\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Due to improved biocompatibility, natural deep eutectic solvents (NADES) are increasingly explored in biomedicine.93 Yet, our understanding of how they interact with biomolecules at multiomic levels- metabolome, proteome, epigenome, and transcriptome &#8211; remains poor. Recently, Agatemor\u2019s group found that a NADES designed from choline and geranic acid (CAGE) upregulates indole-3-lactic acid and 4-hydroxyphenyllactic acid at the metabolomic level, resulting in ligand-independent activation of aryl hydrocarbon receptor to signal the transcription of genes at the transcriptomic level.92 Such metabolic-transcriptomic biochemical crosstalk has important implications for metabolic regulation\/engineering of inflammation, immune response, cell reprogramming, and chemical detoxification.94 This finding prompted new questions [&hellip;]<\/p>\n","protected":false},"author":20,"featured_media":14106,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[158],"tags":[],"class_list":["post-14037","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reu_03_projects"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Activity of NADES at the Multiomic Level - Microanalytical Chemistry Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceweb.clemson.edu\/uacl\/activity-of-nades-at-the-multiomic-level\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Activity of NADES at the Multiomic Level - Microanalytical Chemistry Lab\" \/>\n<meta property=\"og:description\" content=\"Due to improved biocompatibility, natural deep eutectic solvents (NADES) are increasingly explored in biomedicine.93 Yet, our understanding of how they interact with biomolecules at multiomic levels- metabolome, proteome, epigenome, and transcriptome &#8211; remains poor. Recently, Agatemor\u2019s group found that a NADES designed from choline and geranic acid (CAGE) upregulates indole-3-lactic acid and 4-hydroxyphenyllactic acid at the metabolomic level, resulting in ligand-independent activation of aryl hydrocarbon receptor to signal the transcription of genes at the transcriptomic level.92 Such metabolic-transcriptomic biochemical crosstalk has important implications for metabolic regulation\/engineering of inflammation, immune response, cell reprogramming, and chemical detoxification.94 This finding prompted new questions [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/scienceweb.clemson.edu\/uacl\/activity-of-nades-at-the-multiomic-level\/\" \/>\n<meta property=\"og:site_name\" content=\"Microanalytical Chemistry Lab\" \/>\n<meta property=\"article:published_time\" content=\"2025-04-25T02:06:57+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-06T02:24:29+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/REU_project_07.png\" \/>\n\t<meta property=\"og:image:width\" content=\"750\" \/>\n\t<meta property=\"og:image:height\" content=\"775\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"CDG\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@MicroAnalytic11\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"CDG\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/scienceweb.clemson.edu\\\/uacl\\\/activity-of-nades-at-the-multiomic-level\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/scienceweb.clemson.edu\\\/uacl\\\/activity-of-nades-at-the-multiomic-level\\\/\"},\"author\":{\"name\":\"CDG\",\"@id\":\"https:\\\/\\\/scienceweb.clemson.edu\\\/uacl\\\/#\\\/schema\\\/person\\\/84db2eae9183261b17b2280646687289\"},\"headline\":\"Activity of NADES at the Multiomic Level\",\"datePublished\":\"2025-04-25T02:06:57+00:00\",\"dateModified\":\"2025-11-06T02:24:29+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/scienceweb.clemson.edu\\\/uacl\\\/activity-of-nades-at-the-multiomic-level\\\/\"},\"wordCount\":247,\"publisher\":{\"@id\":\"https:\\\/\\\/scienceweb.clemson.edu\\\/uacl\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/scienceweb.clemson.edu\\\/uacl\\\/activity-of-nades-at-the-multiomic-level\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/scienceweb.clemson.edu\\\/uacl\\\/wp-content\\\/uploads\\\/sites\\\/46\\\/2025\\\/04\\\/REU_project_07.png\",\"articleSection\":[\"REU_03_projects\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/scienceweb.clemson.edu\\\/uacl\\\/activity-of-nades-at-the-multiomic-level\\\/\",\"url\":\"https:\\\/\\\/scienceweb.clemson.edu\\\/uacl\\\/activity-of-nades-at-the-multiomic-level\\\/\",\"name\":\"Activity of NADES at the Multiomic Level - 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