{"id":14033,"date":"2025-04-25T02:01:13","date_gmt":"2025-04-25T02:01:13","guid":{"rendered":"https:\/\/scienceweb.clemson.edu\/uacl-new\/?p=14033"},"modified":"2025-11-06T02:17:20","modified_gmt":"2025-11-06T02:17:20","slug":"interaction-of-des-with-cells","status":"publish","type":"post","link":"https:\/\/scienceweb.clemson.edu\/uacl\/interaction-of-des-with-cells\/","title":{"rendered":"Interaction of DES with cells"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"14033\" class=\"elementor elementor-14033\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-eb59e48 e-flex e-con-boxed mk-enable-fade-animation-none mk-sticky-column-false mk-sticky-column-disable-tablet e-con e-parent\" data-id=\"eb59e48\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_sticky&quot;:&quot;false&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-5756391 e-con-full e-flex mk-enable-fade-animation-none mk-sticky-column-false mk-sticky-column-disable-tablet e-con e-child\" data-id=\"5756391\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_sticky&quot;:&quot;false&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7433722 mk-enable-fade-animation-none elementor-widget elementor-widget-theme-post-featured-image elementor-widget-image\" data-id=\"7433722\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_infinite&quot;:&quot;false&quot;,&quot;mk_ext_is_scrollme&quot;:&quot;false&quot;}\" data-widget_type=\"theme-post-featured-image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"750\" height=\"775\" src=\"https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/REU_project_05.png\" class=\"attachment-large size-large wp-image-14104\" alt=\"REU project 05\" srcset=\"https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/REU_project_05.png 750w, https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/REU_project_05-290x300.png 290w\" sizes=\"(max-width: 750px) 100vw, 750px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-84e5f64 e-con-full e-flex mk-enable-fade-animation-none mk-sticky-column-false mk-sticky-column-disable-tablet e-con e-child\" data-id=\"84e5f64\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_sticky&quot;:&quot;false&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4b501aa mk-enable-fade-animation-none elementor-widget elementor-widget-text-editor\" data-id=\"4b501aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_infinite&quot;:&quot;false&quot;,&quot;mk_ext_is_scrollme&quot;:&quot;false&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000\">The vast majority (&gt;99%) of the injected nanoparticles do not reach their intended destination, which hampers their clinical application. Addressing this problem, the Tanner lab has recently demonstrated that specific choline-based DES can direct preferential accumulation in certain tissues while others can promote transdermal transport or even hitchhike onto blood cells.\u00a0Considering her unique expertise, REU participants will be tasked with unveiling the role of DES in drug delivery, following the hypothesis that such interactions depend on the chemical properties of the components selected to build the DES. Thus, participants will first synthesize a library of DES based on choline and organic acids\u00a0ranging in structure, hydrophobicity, and pKa. These DES will be used to coat poly(lactic-co-glycolic) acid nanoparticles, which will be synthesized in-house via nanoprecipitation and solvent evaporation using acetonitrile. Upon characterization (hydrodynamic diameter, zeta potential, and amount of DES adsorbed), participants will investigate their hemocompatibility by RBC hemolysis (incubation at 37\u00b0C, centrifugation, and measurement of absorbance at 405 nm). This information will be used to build a database, which will be augmented using RDKit and analyzed using AI models to identify patterns and extract the most significant features controlling hemocompatibility (in collaboration with Garcia\u2019s team). As a result, participants will gain experience in synthesizing DES, characterization methods (including DLS and NMR), and biological methods.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-dddd588 e-flex e-con-boxed mk-enable-fade-animation-none mk-sticky-column-false mk-sticky-column-disable-tablet e-con e-parent\" data-id=\"dddd588\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_sticky&quot;:&quot;false&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-096747c mk-enable-fade-animation-none elementor-widget elementor-widget-spacer\" data-id=\"096747c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_infinite&quot;:&quot;false&quot;,&quot;mk_ext_is_scrollme&quot;:&quot;false&quot;}\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-89164b6 e-flex e-con-boxed mk-enable-fade-animation-none mk-sticky-column-false mk-sticky-column-disable-tablet e-con e-parent\" data-id=\"89164b6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_sticky&quot;:&quot;false&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d4b92f0 e-con-full e-flex mk-enable-fade-animation-none mk-sticky-column-false mk-sticky-column-disable-tablet e-con e-child\" data-id=\"d4b92f0\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_sticky&quot;:&quot;false&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c77a6bf mk-enable-fade-animation-none elementor-widget elementor-widget-image\" data-id=\"c77a6bf\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_infinite&quot;:&quot;false&quot;,&quot;mk_ext_is_scrollme&quot;:&quot;false&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"700\" height=\"700\" data-src=\"https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/eden_tanner.jpg\" class=\"attachment-large size-large wp-image-14735 lazyload\" alt=\"eden tanner\" data-srcset=\"https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/eden_tanner.jpg 700w, https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/eden_tanner-300x300.jpg 300w, https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/eden_tanner-150x150.jpg 150w, https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/eden_tanner-105x105.jpg 105w\" data-sizes=\"(max-width: 700px) 100vw, 700px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 700px; --smush-placeholder-aspect-ratio: 700\/700;\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c5b08de e-con-full e-flex mk-enable-fade-animation-none mk-sticky-column-false mk-sticky-column-disable-tablet e-con e-child\" data-id=\"c5b08de\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_sticky&quot;:&quot;false&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ad04679 mk-enable-fade-animation-none elementor-widget elementor-widget-text-editor\" data-id=\"ad04679\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;mk-animation-effect&quot;:&quot;none&quot;,&quot;mk_ext_is_infinite&quot;:&quot;false&quot;,&quot;mk_ext_is_scrollme&quot;:&quot;false&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000\"><strong>Students working in this project will be mentored by Dr. Eden Tanner, at University of Mississippi<\/strong><\/span><\/p><p><span style=\"color: #000000\"><a style=\"color: #000000\" href=\"https:\/\/chemistry.olemiss.edu\/eden-tanner\/\"><img decoding=\"async\" class=\"size-full wp-image-14115 lazyload\" title=\"icons8 website\" data-src=\"https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/icons8-website.gif\" alt=\"icons8 website\" width=\"50\" height=\"50\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 50px; --smush-placeholder-aspect-ratio: 50\/50;\" \/><\/a> <a style=\"color: #000000\" href=\"https:\/\/scholar.google.com\/citations?user=sZLumo8AAAAJ&amp;hl=en\"><img decoding=\"async\" class=\"size-full wp-image-14116 lazyload\" title=\"icons8 google scholar 50\" data-src=\"https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/icons8-google-scholar-50.png\" alt=\"icons8 google scholar 50\" width=\"50\" height=\"50\" data-srcset=\"https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/icons8-google-scholar-50.png 50w, https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/elementor\/thumbs\/icons8-google-scholar-50-r53orhp59nh1i1yl0nelevkoz1i2lwo3xev7el2dy6.png 35w\" data-sizes=\"(max-width: 50px) 100vw, 50px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 50px; --smush-placeholder-aspect-ratio: 50\/50;\" \/><\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>The vast majority (&gt;99%) of the injected nanoparticles do not reach their intended destination, which hampers their clinical application. Addressing this problem, the Tanner lab has recently demonstrated that specific choline-based DES can direct preferential accumulation in certain tissues while others can promote transdermal transport or even hitchhike onto blood cells.\u00a0Considering her unique expertise, REU participants will be tasked with unveiling the role of DES in drug delivery, following the hypothesis that such interactions depend on the chemical properties of the components selected to build the DES. Thus, participants will first synthesize a library of DES based on choline and [&hellip;]<\/p>\n","protected":false},"author":20,"featured_media":14104,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[158],"tags":[],"class_list":["post-14033","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reu_03_projects"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Interaction of DES with cells - Microanalytical Chemistry Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/scienceweb.clemson.edu\/uacl\/interaction-of-des-with-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Interaction of DES with cells - Microanalytical Chemistry Lab\" \/>\n<meta property=\"og:description\" content=\"The vast majority (&gt;99%) of the injected nanoparticles do not reach their intended destination, which hampers their clinical application. Addressing this problem, the Tanner lab has recently demonstrated that specific choline-based DES can direct preferential accumulation in certain tissues while others can promote transdermal transport or even hitchhike onto blood cells.\u00a0Considering her unique expertise, REU participants will be tasked with unveiling the role of DES in drug delivery, following the hypothesis that such interactions depend on the chemical properties of the components selected to build the DES. Thus, participants will first synthesize a library of DES based on choline and [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/scienceweb.clemson.edu\/uacl\/interaction-of-des-with-cells\/\" \/>\n<meta property=\"og:site_name\" content=\"Microanalytical Chemistry Lab\" \/>\n<meta property=\"article:published_time\" content=\"2025-04-25T02:01:13+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-06T02:17:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/scienceweb.clemson.edu\/uacl\/wp-content\/uploads\/sites\/46\/2025\/04\/REU_project_05.png\" \/>\n\t<meta property=\"og:image:width\" content=\"750\" \/>\n\t<meta property=\"og:image:height\" content=\"775\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"CDG\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@MicroAnalytic11\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"CDG\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/scienceweb.clemson.edu\\\/uacl\\\/interaction-of-des-with-cells\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/scienceweb.clemson.edu\\\/uacl\\\/interaction-of-des-with-cells\\\/\"},\"author\":{\"name\":\"CDG\",\"@id\":\"https:\\\/\\\/scienceweb.clemson.edu\\\/uacl\\\/#\\\/schema\\\/person\\\/84db2eae9183261b17b2280646687289\"},\"headline\":\"Interaction of DES with cells\",\"datePublished\":\"2025-04-25T02:01:13+00:00\",\"dateModified\":\"2025-11-06T02:17:20+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/scienceweb.clemson.edu\\\/uacl\\\/interaction-of-des-with-cells\\\/\"},\"wordCount\":238,\"publisher\":{\"@id\":\"https:\\\/\\\/scienceweb.clemson.edu\\\/uacl\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/scienceweb.clemson.edu\\\/uacl\\\/interaction-of-des-with-cells\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/scienceweb.clemson.edu\\\/uacl\\\/wp-content\\\/uploads\\\/sites\\\/46\\\/2025\\\/04\\\/REU_project_05.png\",\"articleSection\":[\"REU_03_projects\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/scienceweb.clemson.edu\\\/uacl\\\/interaction-of-des-with-cells\\\/\",\"url\":\"https:\\\/\\\/scienceweb.clemson.edu\\\/uacl\\\/interaction-of-des-with-cells\\\/\",\"name\":\"Interaction of DES with cells - 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Addressing this problem, the Tanner lab has recently demonstrated that specific choline-based DES can direct preferential accumulation in certain tissues while others can promote transdermal transport or even hitchhike onto blood cells.\u00a0Considering her unique expertise, REU participants will be tasked with unveiling the role of DES in drug delivery, following the hypothesis that such interactions depend on the chemical properties of the components selected to build the DES. 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