{"id":4552,"date":"2025-02-11T15:41:08","date_gmt":"2025-02-11T20:41:08","guid":{"rendered":"https:\/\/scienceweb.clemson.edu\/imms\/?p=4552"},"modified":"2025-02-11T15:44:00","modified_gmt":"2025-02-11T20:44:00","slug":"4552-2","status":"publish","type":"post","link":"https:\/\/scienceweb.clemson.edu\/imms\/4552-2\/","title":{"rendered":"Rapid differentiation of xylazine metabolites using SLIM IM-MS"},"content":{"rendered":"<h1 id=\"sect176\"><span class=\"title_heading\">Rapid differentiation of xylazine metabolites using SLIM IM-MS<\/span><\/h1>\n<p><span class=\"hlFld-ContribAuthor\">Ralph Aderorho<\/span><span class=\"comma-separator\">,\u00a0<\/span><span class=\"hlFld-ContribAuthor\">Shadrack Wilson Lucas<\/span><span class=\"comma-separator\">, and <\/span><span class=\"hlFld-ContribAuthor\">Christopher D. Chouinard<\/span><strong>*<\/strong><\/p>\n<div class=\"article_header-cite-this\"><span class=\"cit-title\"><i>Anal. Methods.<\/i><\/span>\u00a0<span class=\"cit-year-info\">2024<\/span><span class=\"cit-volume\">, 16<\/span><span class=\"cit-issue\">, 4041-4044<\/span><\/div>\n<div class=\"article_header-epubdate\">\n<p><span class=\"pub-date epub-date\">Publication Date<\/span><span class=\"date-separator\">: June 5<\/span><span class=\"pub-date-value\">, 2024<\/span><\/p>\n<div class=\"article_header-history base dropBlock\"><a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlehtml\/2024\/ay\/d4ay00801d\">https:\/\/pubs.rsc.org\/en\/content\/articlehtml\/2024\/ay\/d4ay00801d<\/a><\/div>\n<\/div>\n<div><\/div>\n<div>Xylazine represents an increased threat to the recreational drug market. In this study, we present a rapid strategy for identifying xylazine and differentiating its common isomeric metabolites using Structures for Lossless Ion Manipulations (SLIM) ion mobility coupled to high-resolution\/tandem mass spectrometry (IM-HRMS\/MS). Chemical derivatization using dansyl chloride also assisted with separations and led to identification of resolvable reaction product atropisomers.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Rapid differentiation of xylazine metabolites using SLIM IM-MS Ralph Aderorho,\u00a0Shadrack Wilson Lucas, and Christopher D. Chouinard* Anal. Methods.\u00a02024, 16, 4041-4044 Publication Date: June 5, 2024 https:\/\/pubs.rsc.org\/en\/content\/articlehtml\/2024\/ay\/d4ay00801d Xylazine represents an increased threat to the recreational drug market. In this study, we present a rapid strategy for identifying xylazine and differentiating its common isomeric metabolites using Structures&hellip;<\/p>\n","protected":false},"author":42,"featured_media":4553,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[115,98],"tags":[],"class_list":["post-4552","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-analytical-papers","category-115","category-98","description-off"],"_links":{"self":[{"href":"https:\/\/scienceweb.clemson.edu\/imms\/wp-json\/wp\/v2\/posts\/4552","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scienceweb.clemson.edu\/imms\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scienceweb.clemson.edu\/imms\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/imms\/wp-json\/wp\/v2\/users\/42"}],"replies":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/imms\/wp-json\/wp\/v2\/comments?post=4552"}],"version-history":[{"count":0,"href":"https:\/\/scienceweb.clemson.edu\/imms\/wp-json\/wp\/v2\/posts\/4552\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/imms\/wp-json\/wp\/v2\/media\/4553"}],"wp:attachment":[{"href":"https:\/\/scienceweb.clemson.edu\/imms\/wp-json\/wp\/v2\/media?parent=4552"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/imms\/wp-json\/wp\/v2\/categories?post=4552"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/imms\/wp-json\/wp\/v2\/tags?post=4552"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}