{"id":2087,"date":"2021-03-07T15:57:35","date_gmt":"2021-03-07T15:57:35","guid":{"rendered":"https:\/\/scienceweb.clemson.edu\/imms\/?page_id=2087"},"modified":"2025-09-25T11:35:04","modified_gmt":"2025-09-25T15:35:04","slug":"research-projects","status":"publish","type":"page","link":"https:\/\/scienceweb.clemson.edu\/imms\/research-projects\/","title":{"rendered":"Research Projects"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text css=&#8221;&#8221;]<\/p>\n<h1>Research Projects<\/h1>\n<p>[\/vc_column_text][vc_separator color=&#8221;custom&#8221; border_width=&#8221;2&#8243; accent_color=&#8221;#f56600&#8243;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text css=&#8221;&#8221;]<\/p>\n<h2>\u00a0ion mobility-mass spectrometry (IM-MS)<\/h2>\n<p>&nbsp;[\/vc_column_text][vc_column_text]Research\u00a0in this group involves ion mobility-mass spectrometry (IM-MS), a powerful technique that provides two separate dimensions of chemical separations information for improving confidence in identification and quantitation in metabolomics, lipidomics, and proteomics. Our projects range from instrument development to biological\/clinical applications to fundamental studies of gas-phase chemistry and structure.[\/vc_column_text][vc_separator color=&#8221;custom&#8221; border_width=&#8221;2&#8243; accent_color=&#8221;#f56600&#8243;][vc_separator color=&#8221;custom&#8221; border_width=&#8221;2&#8243; accent_color=&#8221;#f56600&#8243;][\/vc_column][\/vc_row][vc_row][vc_column]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.blog-shortcode.blog-list-shortcode-id-764239b4aed15454de58860541aaeb87.dividers-on.classic-layout-list article {\n  margin-top: 50px;\n  padding-top: 0;\n}\n.blog-shortcode.blog-list-shortcode-id-764239b4aed15454de58860541aaeb87.dividers-on.classic-layout-list article:first-of-type {\n  margin-top: 0;\n  padding-top: 0;\n}\n.blog-shortcode.blog-list-shortcode-id-764239b4aed15454de58860541aaeb87.classic-layout-list.mode-list .post-thumbnail-wrap {\n  width: 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}\n}<\/style><div class=\"articles-list blog-shortcode mode-list blog-list-shortcode-id-764239b4aed15454de58860541aaeb87 classic-layout-list content-bg-on jquery-filter scale-img dt-icon-bg-off loading-effect-fade-in\" data-cur-page=\"1\" data-post-limit=\"-1\" data-pagination-mode=\"none\"><article class=\"post project-odd visible post-4525 type-post status-publish format-standard has-post-thumbnail hentry category-research-projects category-121 description-off\" data-name=\"IM-MS Measurement of Anabolic Steroids and Other Performance-Enhancing Drugs for Anti-Doping Applications\" data-date=\"2024-04-16T17:13:24-04:00\">\n\n<div class=\"post-thumbnail-wrap\">\n\t<div class=\"post-thumbnail\">\n\n\t\t\n\t\t\n\t\t<a href=\"https:\/\/scienceweb.clemson.edu\/imms\/im-ms-measurement-of-anabolic-steroids-and-other-performance-enhancing-drugs-for-anti-doping-applications\/\" class=\"post-thumbnail-rollover layzr-bg layzr-bg\" ><img fetchpriority=\"high\" decoding=\"async\" class=\"blog-thumb-lazy-load preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20768%20512&#39;%2F%3E\" data-src=\"https:\/\/scienceweb.clemson.edu\/imms\/wp-content\/uploads\/sites\/32\/2024\/04\/TOC-figure-768x512.jpg\" data-srcset=\"https:\/\/scienceweb.clemson.edu\/imms\/wp-content\/uploads\/sites\/32\/2024\/04\/TOC-figure-768x512.jpg 768w, https:\/\/scienceweb.clemson.edu\/imms\/wp-content\/uploads\/sites\/32\/2024\/04\/TOC-figure-788x525.jpg 788w\" loading=\"eager\" style=\"--ratio: 768 \/ 512\" sizes=\"(max-width: 768px) 100vw, 768px\" alt=\"TOC figure\" title=\"TOC figure\" width=\"768\" height=\"512\"  \/><\/a>\n\t<\/div>\n<\/div>\n\n\n<div class=\"post-entry-content\">\n\n\t<h3 class=\"entry-title\">\n\t\t<a href=\"https:\/\/scienceweb.clemson.edu\/imms\/im-ms-measurement-of-anabolic-steroids-and-other-performance-enhancing-drugs-for-anti-doping-applications\/\" title=\"IM-MS Measurement of Anabolic Steroids and Other Performance-Enhancing Drugs for Anti-Doping Applications\" rel=\"bookmark\">IM-MS Measurement of Anabolic Steroids and Other Performance-Enhancing Drugs for Anti-Doping Applications<\/a>\n\t<\/h3>\n\n\t<div class=\"entry-meta\"><span class=\"category-link\"><a href=\"https:\/\/scienceweb.clemson.edu\/imms\/category\/research-projects\/\" >Research Projects<\/a><\/span><a class=\"author vcard\" href=\"https:\/\/scienceweb.clemson.edu\/imms\/author\/cchouin\/\" title=\"View all posts by cchouin\" rel=\"author\">By <span class=\"fn\">cchouin<\/span><\/a><a href=\"https:\/\/scienceweb.clemson.edu\/imms\/2024\/04\/16\/\" title=\"5:13 pm\" class=\"data-link\" rel=\"bookmark\"><time class=\"entry-date updated\" datetime=\"2024-04-16T17:13:24-04:00\">April 16, 2024<\/time><\/a><\/div>\n\t<div class=\"entry-excerpt\"><p>Mass spectrometry has been the technique of choice in anti-doping labs since the Los Angeles Olympic Games in 1984. Since then, a combination of targeted tandem mass spectrometry and high-resolution techniques have been used to quantify and identify anabolic steroids and other performance-enhancing drugs, respectively. Recently, the promise of ion mobility-mass spectrometry (IM-MS) has been&hellip;<\/p>\n<\/div>\n\t\n<a href=\"https:\/\/scienceweb.clemson.edu\/imms\/im-ms-measurement-of-anabolic-steroids-and-other-performance-enhancing-drugs-for-anti-doping-applications\/\" class=\"post-details details-type-link\" aria-label=\"Read more about IM-MS Measurement of Anabolic Steroids and Other Performance-Enhancing Drugs for Anti-Doping Applications\">Read more<i class=\"dt-icon-the7-arrow-03\" aria-hidden=\"true\"><\/i><\/a>\n\n<\/div><\/article><article class=\"post project-odd visible post-4512 type-post status-publish format-standard has-post-thumbnail hentry category-research-projects category-121 description-off\" data-name=\"Fundamental Studies of Fentanyl Protomers and their Gas-Phase Structure\" data-date=\"2024-04-11T14:25:54-04:00\">\n\n<div class=\"post-thumbnail-wrap\">\n\t<div class=\"post-thumbnail\">\n\n\t\t\n\t\t\n\t\t<a href=\"https:\/\/scienceweb.clemson.edu\/imms\/fundamental-studies-of-fentanyl-protomers-and-their-gas-phase-structure\/\" class=\"post-thumbnail-rollover layzr-bg layzr-bg\" ><img decoding=\"async\" class=\"blog-thumb-lazy-load preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20768%20512&#39;%2F%3E\" data-src=\"https:\/\/scienceweb.clemson.edu\/imms\/wp-content\/uploads\/sites\/32\/2024\/04\/1-s2.0-S1387380623001768-ga1_lrg-768x512.jpg\" data-srcset=\"https:\/\/scienceweb.clemson.edu\/imms\/wp-content\/uploads\/sites\/32\/2024\/04\/1-s2.0-S1387380623001768-ga1_lrg-768x512.jpg 768w, https:\/\/scienceweb.clemson.edu\/imms\/wp-content\/uploads\/sites\/32\/2024\/04\/1-s2.0-S1387380623001768-ga1_lrg-1306x870.jpg 1306w\" loading=\"eager\" style=\"--ratio: 768 \/ 512\" sizes=\"(max-width: 768px) 100vw, 768px\" alt=\"1 s2.0 S1387380623001768 ga1 lrg\" title=\"1 s2.0 S1387380623001768 ga1 lrg\" width=\"768\" height=\"512\"  \/><\/a>\n\t<\/div>\n<\/div>\n\n\n<div class=\"post-entry-content\">\n\n\t<h3 class=\"entry-title\">\n\t\t<a href=\"https:\/\/scienceweb.clemson.edu\/imms\/fundamental-studies-of-fentanyl-protomers-and-their-gas-phase-structure\/\" title=\"Fundamental Studies of Fentanyl Protomers and their Gas-Phase Structure\" rel=\"bookmark\">Fundamental Studies of Fentanyl Protomers and their Gas-Phase Structure<\/a>\n\t<\/h3>\n\n\t<div class=\"entry-meta\"><span class=\"category-link\"><a href=\"https:\/\/scienceweb.clemson.edu\/imms\/category\/research-projects\/\" >Research Projects<\/a><\/span><a class=\"author vcard\" href=\"https:\/\/scienceweb.clemson.edu\/imms\/author\/cchouin\/\" title=\"View all posts by cchouin\" rel=\"author\">By <span class=\"fn\">cchouin<\/span><\/a><a href=\"https:\/\/scienceweb.clemson.edu\/imms\/2024\/04\/11\/\" title=\"2:25 pm\" class=\"data-link\" rel=\"bookmark\"><time class=\"entry-date updated\" datetime=\"2024-04-11T14:25:54-04:00\">April 11, 2024<\/time><\/a><\/div>\n\t<div class=\"entry-excerpt\"><p>Protomers, or prototropic isomers, are protonation site isomers than can be resolved using ion mobility spectrometry. Dating back to their first report by Karpas et al. in 1990, decades of literature have studied their fundamental properties. Recently, our group and others have identified the presence of protomers for many fentanyl analogues, owing to their multiple&hellip;<\/p>\n<\/div>\n\t\n<a href=\"https:\/\/scienceweb.clemson.edu\/imms\/fundamental-studies-of-fentanyl-protomers-and-their-gas-phase-structure\/\" class=\"post-details details-type-link\" aria-label=\"Read more about Fundamental Studies of Fentanyl Protomers and their Gas-Phase Structure\">Read more<i class=\"dt-icon-the7-arrow-03\" aria-hidden=\"true\"><\/i><\/a>\n\n<\/div><\/article><article class=\"post project-odd visible post-4511 type-post status-publish format-standard has-post-thumbnail hentry category-research-projects category-121 description-off\" data-name=\"Chemical Reactions and Noncovalent Complexes as Ion Mobility &#8216;Shift Reagents&#8217;\" data-date=\"2024-04-11T14:23:14-04:00\">\n\n<div class=\"post-thumbnail-wrap\">\n\t<div class=\"post-thumbnail\">\n\n\t\t\n\t\t\n\t\t<a href=\"https:\/\/scienceweb.clemson.edu\/imms\/chemical-reactions-and-noncovalent-complexes-as-ion-mobility-shift-reagents\/\" class=\"post-thumbnail-rollover layzr-bg layzr-bg\" ><img decoding=\"async\" class=\"blog-thumb-lazy-load preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20420%20280&#39;%2F%3E\" data-src=\"https:\/\/scienceweb.clemson.edu\/imms\/wp-content\/uploads\/sites\/32\/2024\/04\/Screenshot-2024-04-08-162738-420x280.png\" data-srcset=\"https:\/\/scienceweb.clemson.edu\/imms\/wp-content\/uploads\/sites\/32\/2024\/04\/Screenshot-2024-04-08-162738-420x280.png 420w\" loading=\"eager\" style=\"--ratio: 420 \/ 280\" sizes=\"(max-width: 420px) 100vw, 420px\" alt=\"Screenshot 2024 04 08 162738\" title=\"Screenshot 2024 04 08 162738\" width=\"420\" height=\"280\"  \/><\/a>\n\t<\/div>\n<\/div>\n\n\n<div class=\"post-entry-content\">\n\n\t<h3 class=\"entry-title\">\n\t\t<a href=\"https:\/\/scienceweb.clemson.edu\/imms\/chemical-reactions-and-noncovalent-complexes-as-ion-mobility-shift-reagents\/\" title=\"Chemical Reactions and Noncovalent Complexes as Ion Mobility &#8216;Shift Reagents&#8217;\" rel=\"bookmark\">Chemical Reactions and Noncovalent Complexes as Ion Mobility &#8216;Shift Reagents&#8217;<\/a>\n\t<\/h3>\n\n\t<div class=\"entry-meta\"><span class=\"category-link\"><a href=\"https:\/\/scienceweb.clemson.edu\/imms\/category\/research-projects\/\" >Research Projects<\/a><\/span><a class=\"author vcard\" href=\"https:\/\/scienceweb.clemson.edu\/imms\/author\/cchouin\/\" title=\"View all posts by cchouin\" rel=\"author\">By <span class=\"fn\">cchouin<\/span><\/a><a href=\"https:\/\/scienceweb.clemson.edu\/imms\/2024\/04\/11\/\" title=\"2:23 pm\" class=\"data-link\" rel=\"bookmark\"><time class=\"entry-date updated\" datetime=\"2024-04-11T14:23:14-04:00\">April 11, 2024<\/time><\/a><\/div>\n\t<div class=\"entry-excerpt\"><p>Where the resolving power of IM-MS techniques is insufficient to differentiate challenging isomers, various chemical approaches have been used to alter their mobility with the goal of better separations. We are primarily focused on simple, fast, and inexpensive reactions targeting common steroid functional groups. Thus far, we have published on reactions with ozone, simple carbonyls&hellip;<\/p>\n<\/div>\n\t\n<a href=\"https:\/\/scienceweb.clemson.edu\/imms\/chemical-reactions-and-noncovalent-complexes-as-ion-mobility-shift-reagents\/\" class=\"post-details details-type-link\" aria-label=\"Read more about Chemical Reactions and Noncovalent Complexes as Ion Mobility &#8216;Shift Reagents&#8217;\">Read more<i class=\"dt-icon-the7-arrow-03\" aria-hidden=\"true\"><\/i><\/a>\n\n<\/div><\/article><article class=\"post project-odd visible post-4506 type-post status-publish format-standard has-post-thumbnail hentry category-research-projects category-121 description-off\" data-name=\"Detection of New Psychoactive Substances (NPS) and Other Illicit Drugs\" data-date=\"2024-04-10T08:49:01-04:00\">\n\n<div class=\"post-thumbnail-wrap\">\n\t<div class=\"post-thumbnail\">\n\n\t\t\n\t\t\n\t\t<a href=\"https:\/\/scienceweb.clemson.edu\/imms\/detection-of-new-psychoactive-substances-nps-and-other-illicit-drugs\/\" class=\"post-thumbnail-rollover layzr-bg layzr-bg\" ><img decoding=\"async\" class=\"blog-thumb-lazy-load preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20768%20512&#39;%2F%3E\" data-src=\"https:\/\/scienceweb.clemson.edu\/imms\/wp-content\/uploads\/sites\/32\/2024\/04\/Cover-Art_PDF-NO-BLEEDS-768x512.jpg\" data-srcset=\"https:\/\/scienceweb.clemson.edu\/imms\/wp-content\/uploads\/sites\/32\/2024\/04\/Cover-Art_PDF-NO-BLEEDS-768x512.jpg 768w, https:\/\/scienceweb.clemson.edu\/imms\/wp-content\/uploads\/sites\/32\/2024\/04\/Cover-Art_PDF-NO-BLEEDS-1306x870.jpg 1306w\" loading=\"eager\" style=\"--ratio: 768 \/ 512\" sizes=\"(max-width: 768px) 100vw, 768px\" alt=\"Cover Art PDF NO BLEEDS\" title=\"Cover Art PDF NO BLEEDS\" width=\"768\" height=\"512\"  \/><\/a>\n\t<\/div>\n<\/div>\n\n\n<div class=\"post-entry-content\">\n\n\t<h3 class=\"entry-title\">\n\t\t<a href=\"https:\/\/scienceweb.clemson.edu\/imms\/detection-of-new-psychoactive-substances-nps-and-other-illicit-drugs\/\" title=\"Detection of New Psychoactive Substances (NPS) and Other Illicit Drugs\" rel=\"bookmark\">Detection of New Psychoactive Substances (NPS) and Other Illicit Drugs<\/a>\n\t<\/h3>\n\n\t<div class=\"entry-meta\"><span class=\"category-link\"><a href=\"https:\/\/scienceweb.clemson.edu\/imms\/category\/research-projects\/\" >Research Projects<\/a><\/span><a class=\"author vcard\" href=\"https:\/\/scienceweb.clemson.edu\/imms\/author\/cchouin\/\" title=\"View all posts by cchouin\" rel=\"author\">By <span class=\"fn\">cchouin<\/span><\/a><a href=\"https:\/\/scienceweb.clemson.edu\/imms\/2024\/04\/10\/\" title=\"8:49 am\" class=\"data-link\" rel=\"bookmark\"><time class=\"entry-date updated\" datetime=\"2024-04-10T08:49:01-04:00\">April 10, 2024<\/time><\/a><\/div>\n\t<div class=\"entry-excerpt\"><p>New psychoactive substances (NPS) are a broad class of illicit drugs that pose a significant public health threat. Our group is developing novel ion mobility-mass spectrometry (IM-MS) methods and technology for their detection. &nbsp; Representative Papers: Separation and Characterization of Synthetic Cannabinoid Metabolite Isomers Using SLIM High-Resolution Ion Mobility-Tandem Mass Spectrometry (HRIM-MS\/MS) Improved separation of&hellip;<\/p>\n<\/div>\n\t\n<a href=\"https:\/\/scienceweb.clemson.edu\/imms\/detection-of-new-psychoactive-substances-nps-and-other-illicit-drugs\/\" class=\"post-details details-type-link\" aria-label=\"Read more about Detection of New Psychoactive Substances (NPS) and Other Illicit Drugs\">Read more<i class=\"dt-icon-the7-arrow-03\" aria-hidden=\"true\"><\/i><\/a>\n\n<\/div><\/article><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text css=&#8221;&#8221;] Research Projects [\/vc_column_text][vc_separator color=&#8221;custom&#8221; border_width=&#8221;2&#8243; accent_color=&#8221;#f56600&#8243;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text css=&#8221;&#8221;] \u00a0ion mobility-mass spectrometry (IM-MS) &nbsp;[\/vc_column_text][vc_column_text]Research\u00a0in this group involves ion mobility-mass spectrometry (IM-MS), a powerful technique that provides two separate dimensions of chemical separations information for improving confidence in identification and quantitation in metabolomics, lipidomics, and proteomics. Our projects range from instrument development to biological\/clinical applications to&hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":43,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2087","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/scienceweb.clemson.edu\/imms\/wp-json\/wp\/v2\/pages\/2087","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scienceweb.clemson.edu\/imms\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/scienceweb.clemson.edu\/imms\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/imms\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/imms\/wp-json\/wp\/v2\/comments?post=2087"}],"version-history":[{"count":0,"href":"https:\/\/scienceweb.clemson.edu\/imms\/wp-json\/wp\/v2\/pages\/2087\/revisions"}],"wp:attachment":[{"href":"https:\/\/scienceweb.clemson.edu\/imms\/wp-json\/wp\/v2\/media?parent=2087"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}