Biosketch<\/strong><\/h2>\nA native of The Netherlands, Dr. Robert Ren\u00e9 Henri Anholt has built a career as a distinguished researcher and teacher in the field of genetics. In 2018, Anholt was named Provost\u2019s Distinguished Professor of Genetics and Biochemistry, Department of Genetics and Biochemistry, College of Science, Clemson University, and the director of Faculty Excellence for Clemson\u2019s College of Science.\u00a0Anholt began his academic pursuits at The Hebrew University of Jerusalem in Israel, where he earned his Bachelor of Science in 1973. He would go on to receive a Master of Science in biochemistry in 1975 from University College in London, and, in 1982, a Ph.D. in biology from the University of California, San Diego.<\/p>\n
He received an interim postdoctoral appointment from the Salk Institute for Biological Studies in San Diego and was a postdoctoral fellow in the Department of Neuroscience at the Johns Hopkins University School of Medicine in Maryland from 1982\u20131986.\u00a0Anholt was an assistant professor in Duke University Medical Center\u2019s departments of Physiology and Neurobiology from 1986-88 and from 1988\u201393, respectively. From 1992\u201393, he was a member of the Duke Comprehensive Cancer Center. From 1993 through 2018, Anholt held several teaching positions at North Carolina State University. He was a research associate professor in the Department of Zoology (1993\u201396); an associate professor in the Department of Zoology (1996\u20132000); the program director for the W.M. Keck Program for Behavioral Biology (1998\u20132000), and founding director of the W.M. Keck Center for Behavioral Biology (2000\u201318); professor in the Department of Zoology (2000\u201308); the William Neal Reynolds Distinguished Professor of Biology (2008\u201313); and the Willian Neal Reynolds Distinguished Professor of Biological Sciences (2013\u201318). While at N.C. State, Anholt was also a member of the Genomics Sciences Faculty (2000\u201318); an associate member of the Department of Genetics (2000\u201313); a member of the Comparative Biomedical Sciences Program, College of Veterinary Medicine (2006\u201318); and a member of the Comparative Medicine Institute (2014\u201319).\u00a0During his career, Anholt has received numerous awards and special recognitions for his work. He received the Martin Kamen award for most outstanding doctoral thesis in 1982 from the University of California, San Diego. In 2000, he received the Faculty Resource Development Award, College of Agriculture and Life Sciences, N.C. State University. In 2011, he was named a top referee by the Proceedings of the Royal Society B: Biological Sciences, and in 2016 he was honored with the Alexander Quarles Holladay Medal for Excellence at N.C. State University. From 2016\u201319, he was conferred an honorary professorate by China\u2019s Beijing Forestry University. In 2023 he received the University Research, Scholarship and Artistic Achievement Award from Clemson University.\u00a0In addition, Anholt is a member of the Sigma Xi Scientific Research Honor Society, and a fellow of the American Association for the Advancement of Science. He has been published more than 160 times, and is credited, with others, for four inventions relating to his research.<\/p>\n
Research\u00a0<\/strong><\/p>\nAnholt\u2019s research focuses on dissecting the genetic architecture of behavior in the common fruit fly,\u00a0Drosophila melanogaster<\/em>, including olfactory and startle behaviors, phototaxis, aggression and locomotion, and developing Drosophila as a genetic model for identifying ensembles of genes that predispose to human disorders such as alcohol-related phenotypes, substance use disorders and rare genetic diseases. \u00a0\u00a0His laboratory focuses on whole genome transcriptional analyses and the incorporation of state-of-the-art genomic strategies in studies on a wide range of phenotypes, with a special interest in the genetic underpinnings of phenotypic plasticity and genotype-environment interactions using systems approaches. \u00a0His research program is focused on establishing causal relationships between DNA sequence variants and variation in organismal phenotype. The Anholt laboratory has a long and productive history of synergistic collaborations with Dr. Trudy Mackay.<\/p>\nPublications<\/strong><\/p>\nTan S, Carbone MA, Zhou S, Morozova T, Arya G, Zhang F, Anholt RRH, Huang W and Mackay TFC. 2025. Systems genetics of Drosophila aging. Cell Rep<\/span><\/i>, submitted.<\/span><\/span><\/p>\nChaturvedi A, Shankar V, Simkhada B, Lyman RA, Freymuth P, Howansky E, Collins KM, Mackay TFC and Anholt RRH. 2025. Arsenic toxicity in the Drosophila brain at single cell resolution. Front Toxicol,<\/em> submitted.<\/p>\nSimkhada B, Nazario-Yepiz NO, Freymuth PS, Lyman RA, Shankar V, Wiggins K, Flanagan-Steet H, Basu A, Weiss RJ, Anholt RRH and Mackay TFC. 2025. A Drosophila model for mucopolysaccharidosis IIIB. Genetics<\/em> 229,<\/strong> iyae219.<\/p>\nCollins KM, Howansky E, Macon-Foley SC, Adonay ME, Shankar V, Lyman RF, Nazario-Yepiz NO, Brooks, JK, Lyman RA, Mackay TFC and Anholt RRH. 2024.<\/span> Drosophila toxicogenomics: Genetic variation and sexual dimorphism in susceptibility to 4-methylimidazole. Hum Genomics<\/i> 18,<\/b> 119.<\/span><\/span><\/p>\nYamamoto A, Huang W, Carbone MA, Anholt RRH and Mackay TFC. 2024. The genetic basis of incipient sexual isolation in Drosophila melanogaster<\/em>. Proc Biol Sci<\/em> 291,<\/strong> 20240672.<\/p>\nYamamoto A, Huang W, Anholt RRH<\/strong> and Mackay TFC<\/strong>. 2024. The genetic basis of variation in Drosophila melanogaster<\/em> mating behavior. iScience<\/em>, in press.<\/p>\nMackay TFC<\/strong> and Anholt RRH<\/strong>. 2024. Pleiotropy, epistasis, and the genetic architecture of quantitative traits. Nat Rev Genet<\/em>, EPub ahead of print. https:\/\/doi.org\/10.1038\/s41576-024-00711-3<\/p>\nMokashi SS<\/strong>, Shankar V<\/strong>, Johnstun JA, Mackay TFC<\/strong> and Anholt, RRH<\/strong>. 2023. Pleiotropic fitness effects of a Drosophila odorant binding protein. G3: Genes, Genomes,<\/em> Genetics <\/em>13,<\/strong> jkac307.<\/p>\nLyman RF<\/strong>, Lyman RA<\/strong>, Yamamoto A, Huang W, Harbison ST, Zhou S, Anholt RRH<\/strong> and Mackay TFC<\/strong>. 2023. Natural genetic variation in a dopamine receptor is associated with variation in female fertility in Drosophila melanogaster.<\/em> Proc Roy Soc B <\/em>290,<\/strong> 20230375.<\/p>\nMacPherson RA<\/strong>, Shankar V<\/strong>, Anholt RRH<\/strong> and Mackay TFC<\/strong>. 2023. Genetic and genomic analyses of Drosophila melanogaster<\/em> models of chromatin modification disorders. Genetics <\/em>224,<\/strong> iyad061.<\/p>\nAnholt RRH<\/strong> and Mackay TFC<\/strong>. 2023. The genetic architecture of behavioral canalization. Trends Genet <\/em>39,<\/strong> 602-608. <\/em><\/p>\nThe Precision Tox Consortium (95 authors, including R. Anholt<\/strong>). 2023. The Precision Toxicology Initiative. Toxicol Lett<\/em> 383,<\/strong> 33-42.<\/p>\nRand MD, Tennessen JM, Mackay TFC<\/strong> and Anholt RRH<\/strong>. 2023. Perspectives on the Drosophila melanogaster<\/em> model for advances in toxicological science. Curr Protoc<\/em> 3,<\/strong> e870.<\/p>\nMorozova TV, Shankar V<\/strong>, MacPherson RA<\/strong>, Mackay TFC<\/strong> and Anholt RRH<\/strong>. 2022. Modulation of the Drosophila transcriptome by developmental exposure to alcohol. BMC Genomics <\/em>23,<\/strong> 347.<\/p>\nMackay TFC<\/strong> and Anholt RRH<\/strong>. 2022. Gregor Mendel\u2019s legacy in quantitative genetics. PLoS Biology<\/em> 20,<\/strong> e3001692.<\/p>\nMacPherson RA<\/strong>, Shankar V<\/strong>, Sunkara LT<\/strong>, Hannah RC<\/strong>, Campbell III MR<\/strong>, Anholt RRH<\/strong> and Mackay TFC<\/strong>. 2022. Pleiotropic fitness effects of the lncRNA Uhg4<\/em> in Drosophila melanogaster<\/em>. BMC Genomics<\/em> 23,<\/strong> 781.<\/p>\nWalters JD<\/strong>, Hatfield JS<\/strong>, Baker BM<\/strong>, Mackay TFC<\/strong> and Anholt RRH<\/strong>. 2021. A high-throughput microplate feeder assay for the quantification of consumption in Drosophila. J Vis Exp <\/em>172,<\/strong> e62771.<\/p>\nMokashi SS<\/strong>, Shankar V<\/strong>, MacPherson RA<\/strong>, Hannah RC<\/strong>, Mackay TFC <\/strong>and Anholt RRH<\/strong>. 2021. Developmental alcohol exposure in Drosophila: Effects on adult phenotypes and gene expression in the brain. Front Psychiatry <\/em>12,<\/strong> 699033.<\/p>\n\u00d6zsoy ED, Yilmaz M, Patlar B, Emecen G, Durmaz E, Magwire MM, Zhou S, Huang W, Anholt RRH <\/strong>and Mackay TFC<\/strong>. 2021. Epistasis for head morphology in Drosophila melanogaster<\/em>. G3: Genes, Genomes,<\/em> Genetics<\/em> 11,<\/strong> jkab285.<\/p>\nNazario-Yepiz NO<\/strong>, Fern\u00e1ndez Sobaberas J, Lyman R<\/strong>, Campbell MR III<\/strong>, Shankar V<\/strong>, Anholt RRH<\/strong> and Mackay TFC<\/strong>. 2021. Physiological and metabolomic consequences of reduced expression of the brummer<\/em> triglyceride lipase. PLoS One<\/em> 16,<\/strong> e0255198.<\/p>\nHuggett SB, Hatfield JS<\/strong>, Walters JD<\/strong>, McGeary J, Welsh J, Mackay TFC<\/strong>, Anholt RRH<\/strong> and Palmer RHC. 2021. Ibrutinib as a potential therapeutic for cocaine use disorder. Transl Psychiatry<\/em> 11,<\/strong> 623.<\/p>\nBaker BM<\/strong>, Carbone MA, Huang W, Anholt RRH<\/strong> and Mackay TFC<\/strong>. 2021. \u00a0\u00a0Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations of Drosophila melanogaster. Proc Natl Acad Sci USA <\/em>118<\/strong>, e2104131118.<\/p>\nJohnstun JA, Shankar V<\/strong>, Mokashi SS<\/strong>, Sunkara LT<\/strong>, Ihearahu UE, Lyman RL<\/strong>, Mackay TFC<\/strong> and Anholt RRH<\/strong>. 2021. Functional diversification, redundancy and epistasis among paralogs of the Drosophila melanogaster Obp50a-d<\/em> gene cluster. Mol Biol Evol<\/em> 38<\/strong>, 2030-2044.<\/p>\nBaker BM<\/strong>, Mokashi SS<\/strong>, Shankar V<\/strong>, Hatfield JS<\/strong>, Hannah RC<\/strong>, Mackay TFC<\/strong> and Anholt <\/strong>RRH. 2021. The Drosophila brain on cocaine at single-cell resolution. Genome Res<\/em> 31,<\/strong> 1927-1937.<\/p>\nAnholt RRH<\/strong>. 2020. Chemosensation and evolution of Drosophila host plant selection.\u00a0iScience<\/em>\u00a023:<\/strong>\u00a0100799. doi: 10.1016\/j.isci.2019.100799.<\/p>\nAnholt RRH.<\/strong>\u00a02020. Evolution of epistatic networks and the genetic basis of innate behaviors.\u00a0Trends Genet<\/em>.\u00a036<\/strong>: 24-29. doi: 10.1016\/j.tig.2019.10.005.<\/p>\nAnholt RRH<\/strong>, Wolfner MF, O\u2019Grady P and Harbison ST. 2020. Evolution of reproductive behavior.\u00a0Genetics<\/em>\u00a0214<\/strong>: 49-73. doi: 10.1534\/genetics.119.302263.<\/p>\nEverett LJ, Huang W, Zhou S, Carbone MA,\u00a0Lyman RF<\/strong>, Arya GH, Geisz MS, Ma J,\u00a0Morgante F<\/strong>, St Armour G, Turlapati L,\u00a0Anholt RRH<\/strong>\u00a0and\u00a0Mackay TFC<\/strong>. 2020. Gene expression networks in the\u00a0Drosophila<\/em>\u00a0Genetic Reference Panel.\u00a0\u00a0Genome Res<\/em>\u00a030<\/strong>: 485-496. doi: 10.1101\/gr.257592.119.<\/p>\nHuang W, Carbone MA,\u00a0Lyman RF<\/strong>,\u00a0Anholt RRH<\/strong>\u00a0and\u00a0Mackay TFC<\/strong>. 2020. Genotype by environment interaction for gene expression in\u00a0Drosophila melanogaster<\/em>.\u00a0Nat Commun.<\/em>\u00a011<\/strong>: 5451. doi: 10.1038\/s41467-020-19131-y.<\/p>\nHuang W, Campbell T, Carbone MA, Jones WE, Unselt D,\u00a0Anholt RRH<\/strong>\u00a0and\u00a0Mackay TFC.<\/strong>\u00a02020. Context-dependent genetic architecture of\u00a0Drosophila<\/em>\u00a0lifespan.\u00a0PLoS Biol<\/em>\u00a018<\/strong>: e3000645. doi: 10.1371\/journal.pbio.3000645.<\/p>\nSass TN,\u00a0MacPherson RA,<\/strong>\u00a0Mackay TFC<\/strong>\u00a0and\u00a0Anholt RRH<\/strong>. 2020. A high-throughput method for measuring alcohol sedation time of individual\u00a0Drosophila melanogaster. J Vis Exp\u00a0<\/em>158<\/strong>: e61108. doi: 10.3791\/61108.<\/p>\nZhou S,\u00a0Morgante F<\/strong>, Geisz MS, Ma J,\u00a0Anholt RRH<\/strong>\u00a0and\u00a0Mackay TFC<\/strong>. 2020. Systems genetics of the\u00a0Drosophila<\/em>\u00a0metabolome.\u00a0Genome Res<\/em>\u00a030<\/strong>: 392-405. doi: 10.1101\/gr.243030.118.<\/p>\nHighfill CA,\u00a0Baker BM<\/strong>, Stevens SD,\u00a0Anholt RRH<\/strong>\u00a0and\u00a0Mackay TFC<\/strong>. 2019. Genetics of cocaine and methamphetamine consumption and preference in\u00a0Drosophila melanogaster<\/em>.\u00a0PLoS Genet<\/em>\u00a015<\/strong>: e1007834. doi: 10.1371\/journal.pgen.1007834.<\/p>\n <\/p>\n
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Provost\u2019s Distinguished Professor, Department of Genetics and BiochemistryDirector of Faculty Excellence, College of Science Visit the Mackay-Anholt Lab<\/a> Email: ranholt@clemson.eduPhone: 864-889-0521 Biosketch A native of The Netherlands, Dr. Robert Ren\u00e9 Henri Anholt has built a career as a distinguished researcher and teacher in the field of genetics. In 2018, Anholt […]<\/p>\n","protected":false},"author":4,"featured_media":1342,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"Provost\u2019s Distinguished Professor, Department of Genetics and Biochemistry<\/strong>\r\nDirector of Faculty Excellence, College of Science<\/strong>\r\n\r\n[button link=\"https:\/\/scienceweb.clemson.edu\/chg\/mackay-anholt-lab\/\" type=\"big\" color=\"silver\" newwindow=\"yes\"] Visit the Mackay-Anholt Lab[\/button]\r\n\r\nEmail: ranholt@clemson.edu\r\nPhone: 864-889-0521\r\n\r\n![\"Robert](\"https:\/\/scienceweb.clemson.edu\/chg\/wp-content\/uploads\/sites\/4\/2019\/08\/CHG-faculty-robert-anholt-5890-240x300.jpg\")
\r\nBiosketch<\/strong><\/h3>\r\nA native of The Netherlands, Dr. Robert Rene Henri Anholt has built a career as a distinguished researcher and teacher in the field of genetics. In 2018, Anholt was named Provost\u2019s Distinguished Professor of Genetics and Biochemistry, Department of Genetics and Biochemistry, College of Science, Clemson University, and the director of Faculty Excellence for Clemson\u2019s College of Science.\r\n\r\nAnholt began his academic pursuits at The Hebrew University of Jerusalem in Israel, where he earned his Bachelor of Science in 1973. He would go on to receive a Master of Science in biochemistry in 1975 from University College in London, and, in 1982, a Ph.D. in biology from the University of California, San Diego.\r\n\r\nHe received an interim postdoctoral appointment from the Salk Institute for Biological Studies in San Diego and was a postdoctoral fellow in the Department of Neuroscience at the Johns Hopkins University School of Medicine in Maryland from 1982\u20131986.\r\n\r\nAnholt was an assistant professor in Duke University Medical Center\u2019s departments of Physiology and Neurobiology from 1986-88 and from 1988\u201393, respectively. From 1992\u201393, he was a member of the Duke Comprehensive Cancer Center. From 1993 through 2018, Anholt held several teaching positions at North Carolina State University. He was a research associate professor in the Department of Zoology (1993\u201396); an associate professor in the Department of Zoology (1996\u20132000); the program director for the W.M. Keck Program for Behavioral Biology (1998\u20132000), and director of the W.M. Keck Program for Behavioral Biology (2000\u201318); professor in the Department of Zoology (2000\u201308); the William Neal Reynolds Distinguished Professor of Biology (2008\u201313); and the Willian Neal Reynolds Distinguished Professor of Biological Sciences (2013\u201318). While at N.C. State, Anholt was also a member of the Genomics Sciences Faculty (2000\u201318); an associate member of the Department of Genetics (2000\u201313); a member of the Comparative Biomedical Sciences Program, College of Veterinary Medicine (2006\u201318); and a member of the Comparative Medicine Institute (2014\u201319).\r\n\r\nDuring his career, Anholt has received numerous awards and special recognitions for his work. He received the Martin Kamen award for most outstanding doctoral thesis in 1982 from the University of California, San Diego. In 2000, he received the Faculty Resource Development Award, College of Agriculture and Life Sciences, N.C. State University. In 2011, he was named a top referee by the Proceedings of the Royal Society B: Biological Sciences, and in 2016 he was honored with the Alexander Quarles Holladay Medal for Excellence at N.C. State University. From 2016\u201319, he was conferred an honorary professorate by China\u2019s Beijing Forestry University.\r\n\r\nIn addition, Anholt is a member of the Sigma Xi Scientific Research Honor Society, and a fellow of the American Association for the Advancement of Science. He has been published more than 125 times, and is credited, with others, for three inventions relating to his research.\r\nResearch<\/u><\/u><\/b><\/u>\u00a0<\/u><\/b><\/h3>\r\nAnholt\u2019s research focuses on dissecting the genetic architecture of behavior in the common fruit fly, Drosophila melanogaster<\/em>, including olfactory and startle behaviors, phototaxis, aggression and locomotion, and developing Drosophila as a genetic model for identifying ensembles of genes that predispose to human disorders such as alcohol-related phenotypes and ocular hypertension. He is also working to understand the genetic underpinnings of phenotypic plasticity and to determine the functions of the olfactomedin gene family.\r\nRecent Publications<\/strong><\/h3>\r\nAnholt, R. R. H. (2020) Chemosensation and evolution of Drosophila host plant selection. iScience<\/em> 23:<\/strong> 100799.\r\n\r\nAnholt, R. R. H, Wolfner, M. F., O\u2019Grady, P. and Harbison, S. T. (2020) Evolution of reproductive behavior. Genetics<\/em> 214:<\/strong> 49-73.\r\n\r\nAnholt, R. R. H. (2020) Evolution of epistatic networks and the genetic basis of innate behaviors. Trends Genet<\/em>. 36:<\/strong> 24-29.\r\n\r\nZhou, S., Morgante, F., Geisz, M. S., Ma, J., Anholt, R. R. H. and Mackay, T. F. C. (2020) Systems genetics of the Drosophila metabolome<\/em>. Genome Res.<\/em> 30:<\/strong> 392-405.\r\n\r\nHuang, W., Campbell, T., Carbone, M. A., Jones, W. E., Unselt, D., Anholt, R. R. H. and Mackay, T. F. C. (2020) Context-dependent genetic architecture of Drosophila lifespan. PLoS Biology<\/em> 18:<\/strong> e3000645.\r\n\r\nEverett, L., Huang, W., Zhou, S., Carbone, M. A., Lyman, R., Arya, G., Geisz, M. S., Ma, J., Morgante, F., St. Armour, G., Turlapati, L., Anholt, R. R. H. and Mackay, T. F. C. (2020) Gene expression networks in the Drosophila Genetic Reference Panel.\u00a0 Genome Res.<\/em> 30: <\/strong>485-496.\r\n\r\nBioRxiv (2019) doi: https:\/\/doi.org\/10.1101\/816579.\r\n\r\nSass, T. N., MacPherson, R. A., Mackay, T. F. C. and Anholt, R. R. H. (2020) A high-throughput method for measuring alcohol sedation time of individual
![\"Dr.](\"https:\/\/scienceweb.clemson.edu\/chg\/wp-content\/uploads\/sites\/4\/2023\/04\/robert-anholt-1-g-240x300.jpg\")
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