![\"WS](\"https:\/\/scienceweb.clemson.edu\/ihg\/wp-content\/uploads\/sites\/4\/2026\/05\/WS-photo-240x300.jpg\" "\\"WS")
WS photo<\/p><\/div>\n
Graduate Student<\/p>\n
Email: wstine@clemson.edu<\/p>\n
Biosketch<\/strong><\/h3>\nWesley Stine was born in Arizona, and he received bachelor\u2019s degrees in physics and aerospace engineering from Embry-Riddle Aeronautical University in Prescott. He briefly studied engineering at Purdue before switching fields to biophysics, where he worked for a year at Emory as a research associate before entering the doctoral program. During this time he published one paper on the statistics of how bacteria can inherit either healthy or damaged states from their parents while dividing in an antibiotic-infused medium. However, upon joining Laura Finzi and David Dunlap\u2019s lab he switched his concentration to magnetic tweezers, a tool for performing single-molecule biophysics experiments on polymers like DNA. He followed Drs. Finzi and Dunlap to Clemson in 2024, where his activities include writing software for magnetic tweezers and studying the rare but biologically important left-handed form of the DNA helix.<\/p>\n
Research Interests<\/strong><\/h3>\nWesley Stine\u2019s research interests mainly revolve around nucleic acid conformations, and specifically the left-handed DNA helix (known in some contexts as Z-DNA). This is a higher-energy conformation of the DNA molecule which can be produced in vivo<\/em> by superhelical stress, and Z-forming sequences are widely believed to have important roles in gene regulation, immune signaling, degenerative diseases and cancers. In the Finzi-Dunlap lab, Stine creates and studies Z-DNA in vitro<\/em> with magnetic tweezers, an instrument that uses tiny magnetic beads attached to DNA tethers to rotate them between the B and Z-forms and observe their mechanical properties, including possible interactions with Z-binding proteins. He is also involved in a study that searches for evidence that the state of Z-forming sequences in vivo<\/em> is correlated with cell phenotypes, either in cell differentiation among healthy cells, or between healthy and cancerous or otherwise diseased cells.<\/p>\nPublications<\/strong><\/h3>\nStine, W., Akiyama, T., Weiss, D. et al. Lineage-dependent variations in single-cell antibiotic susceptibility reveal the selective inheritance of phenotypic resistance in bacteria. Nat Commun 16, 4655 (2025). https:\/\/doi.org\/10.1038\/s41467-025-59807-x<\/p>\n
<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div> Graduate Student Email: wstine@clemson.edu Biosketch Wesley Stine was born in Arizona, and he received bachelor\u2019s degrees in physics and aerospace engineering from Embry-Riddle Aeronautical University in Prescott. He briefly studied engineering at Purdue before switching fields to biophysics, where he worked for a year at Emory as a research associate before entering the doctoral […]<\/p>\n","protected":false},"author":32,"featured_media":2339,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[caption id=\"attachment_2326\" align=\"alignright\" width=\"240\"] WS photo[\/caption]Graduate Student<\/p>
Email: wstine@clemson.edu<\/p>
Biosketch<\/strong><\/h3>Wesley Stine was born in Arizona, and he received bachelor\u2019s degrees in physics and aerospace engineering from Embry-Riddle Aeronautical University in Prescott. He briefly studied engineering at Purdue before switching fields to biophysics, where he worked for a year at Emory as a research associate before entering the doctoral program. During this time he published one paper on the statistics of how bacteria can inherit either healthy or damaged states from their parents while dividing in an antibiotic-infused medium. However, upon joining Laura Finzi and David Dunlap\u2019s lab he switched his concentration to magnetic tweezers, a tool for performing single-molecule biophysics experiments on polymers like DNA. He followed Drs. Finzi and Dunlap to Clemson in 2024, where his activities include writing software for magnetic tweezers and studying the rare but biologically important left-handed form of the DNA helix.<\/p>
Research Interests<\/strong><\/h3>Wesley Stine\u2019s research interests mainly revolve around nucleic acid conformations, and specifically the left-handed DNA helix (known in some contexts as Z-DNA). This is a higher-energy conformation of the DNA molecule which can be produced in vivo<\/em> by superhelical stress, and Z-forming sequences are widely believed to have important roles in gene regulation, immune signaling, degenerative diseases and cancers. In the Finzi-Dunlap lab, Stine creates and studies Z-DNA in vitro<\/em> with magnetic tweezers, an instrument that uses tiny magnetic beads attached to DNA tethers to rotate them between the B and Z-forms and observe their mechanical properties, including possible interactions with Z-binding proteins. He is also involved in a study that searches for evidence that the state of Z-forming sequences in vivo<\/em> is correlated with cell phenotypes, either in cell differentiation among healthy cells, or between healthy and cancerous or otherwise diseased cells.<\/p>Publications<\/strong><\/h3>Stine, W., Akiyama, T., Weiss, D. et al. Lineage-dependent variations in single-cell antibiotic susceptibility reveal the selective inheritance of phenotypic resistance in bacteria. Nat Commun 16, 4655 (2025). https:\/\/doi.org\/10.1038\/s41467-025-59807-x<\/p>
\u00a0<\/p>","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[10,14,1],"tags":[],"class_list":["post-2338","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-people","category-students","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/posts\/2338","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/users\/32"}],"replies":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/comments?post=2338"}],"version-history":[{"count":0,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/posts\/2338\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/media\/2339"}],"wp:attachment":[{"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/media?parent=2338"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/categories?post=2338"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/tags?post=2338"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Wesley Stine\u2019s research interests mainly revolve around nucleic acid conformations, and specifically the left-handed DNA helix (known in some contexts as Z-DNA). This is a higher-energy conformation of the DNA molecule which can be produced in vivo<\/em> by superhelical stress, and Z-forming sequences are widely believed to have important roles in gene regulation, immune signaling, degenerative diseases and cancers. In the Finzi-Dunlap lab, Stine creates and studies Z-DNA in vitro<\/em> with magnetic tweezers, an instrument that uses tiny magnetic beads attached to DNA tethers to rotate them between the B and Z-forms and observe their mechanical properties, including possible interactions with Z-binding proteins. He is also involved in a study that searches for evidence that the state of Z-forming sequences in vivo<\/em> is correlated with cell phenotypes, either in cell differentiation among healthy cells, or between healthy and cancerous or otherwise diseased cells.<\/p>\n Stine, W., Akiyama, T., Weiss, D. et al. Lineage-dependent variations in single-cell antibiotic susceptibility reveal the selective inheritance of phenotypic resistance in bacteria. Nat Commun 16, 4655 (2025). https:\/\/doi.org\/10.1038\/s41467-025-59807-x<\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Graduate Student<\/p> Email: wstine@clemson.edu<\/p> Wesley Stine was born in Arizona, and he received bachelor\u2019s degrees in physics and aerospace engineering from Embry-Riddle Aeronautical University in Prescott. He briefly studied engineering at Purdue before switching fields to biophysics, where he worked for a year at Emory as a research associate before entering the doctoral program. During this time he published one paper on the statistics of how bacteria can inherit either healthy or damaged states from their parents while dividing in an antibiotic-infused medium. However, upon joining Laura Finzi and David Dunlap\u2019s lab he switched his concentration to magnetic tweezers, a tool for performing single-molecule biophysics experiments on polymers like DNA. He followed Drs. Finzi and Dunlap to Clemson in 2024, where his activities include writing software for magnetic tweezers and studying the rare but biologically important left-handed form of the DNA helix.<\/p> Wesley Stine\u2019s research interests mainly revolve around nucleic acid conformations, and specifically the left-handed DNA helix (known in some contexts as Z-DNA). This is a higher-energy conformation of the DNA molecule which can be produced in vivo<\/em> by superhelical stress, and Z-forming sequences are widely believed to have important roles in gene regulation, immune signaling, degenerative diseases and cancers. In the Finzi-Dunlap lab, Stine creates and studies Z-DNA in vitro<\/em> with magnetic tweezers, an instrument that uses tiny magnetic beads attached to DNA tethers to rotate them between the B and Z-forms and observe their mechanical properties, including possible interactions with Z-binding proteins. He is also involved in a study that searches for evidence that the state of Z-forming sequences in vivo<\/em> is correlated with cell phenotypes, either in cell differentiation among healthy cells, or between healthy and cancerous or otherwise diseased cells.<\/p> Stine, W., Akiyama, T., Weiss, D. et al. Lineage-dependent variations in single-cell antibiotic susceptibility reveal the selective inheritance of phenotypic resistance in bacteria. Nat Commun 16, 4655 (2025). https:\/\/doi.org\/10.1038\/s41467-025-59807-x<\/p> \u00a0<\/p>","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[10,14,1],"tags":[],"class_list":["post-2338","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-people","category-students","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/posts\/2338","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/users\/32"}],"replies":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/comments?post=2338"}],"version-history":[{"count":0,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/posts\/2338\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/media\/2339"}],"wp:attachment":[{"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/media?parent=2338"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/categories?post=2338"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/tags?post=2338"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Publications<\/strong><\/h3>\n
WS photo[\/caption]Biosketch<\/strong><\/h3>
Research Interests<\/strong><\/h3>
Publications<\/strong><\/h3>