![\"Atlanta](\"https:\/\/scienceweb.clemson.edu\/chg\/wp-content\/uploads\/sites\/4\/2025\/05\/Finzi-Laura-006_cropped-003-293x300.jpg\" "\\"Atlanta")
<\/p>\n[et_pb_section fb_built=”1″ admin_label=”section” _builder_version=”4.16″ global_colors_info=”{}”][et_pb_row admin_label=”row” _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Text” _builder_version=”4.27.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
<\/p>\n
Endowed Chair-Med Biophysics<\/p>\n
Email: lfinzi@clemson.edu<\/p>\n
Laura Finzi is a professor of biophysics and the Dr. Waenard L. Miller, Jr. \u201969 and Sheila M. Miller Endowed Chair in Medical Biophysics in the Department of Physics and Astronomy. She is a Fellow of the America Physical Society and on the Editorial Board of Biophysical Reviews. She received a Laurea in Industrial Chemistry from the University of Bologna, Italy and a PhD in Chemistry from the University of New Mexico. She was a postdoctoral fellow with Dr. Carlos Bustamante at The Institute of Molecular Biology in Eugene, OR, and with Dr. Jeff Gelles at Brandeis University. She is recognized internationally for her contributions to the understanding of DNA mechanics, topology and physical interactions relevant to transcription regulation.<\/p>\n
Dr. Finzi\u2019s interests lie at the intersection between physics, chemistry and biology. How does the structure, topology and physical phase of DNA affect transcription and its interaction with proteins? Using single-molecule approaches, Dr. Finzi\u2019s group has unveiled the fundamental mechanisms of genetic switches, the key parameters regulating the strength of protein roadblocks to transcription and the structural features permitting transcription recycling. The knowledge produced by her group about molecular mechanisms is important to understand human disease, guide drug design and advance personalized medicine.<\/p>\n
Jin Qian, Bing Wang, Irina Artsimovitch, David Dunlap, Laura Finzi<\/u> \u201cForce and the \u03b1-C-terminal domains bias RNA polymerase recycling\u201d, Nature Comm<\/em>. https:\/\/www.nature.com\/articles\/s41467-024-51603-3<\/a>. DOI: 10.1038\/s41467-024-51603-3<\/p>\n Jin Qian, Allison Cartee, Wenxuan Xu, Yan Yan, Bing Wang, Irina Artsimovitch, David Dunlap, Laura Finzi<\/u> \u201cReciprocating RNA Polymerase batters through roadblocks\u201d Nature Comm<\/em>., doi:<\/strong>10.1038\/s41467-024-47531-x.<\/p>\n Yue Lu, Gustavo Borjas, Cristine Hendrickson, Zsuzsanna V\u00f6r\u00f6s, David Dunlap, Keith Shearwin and Laura Finzi<\/u>, \u201cProteins mediating different DNA topologies block RNAP elongation with different efficiency.\u201d FEBS Letters<\/em>, 2022, 596<\/strong>, 1994-2006; doi<\/strong>:10.1002\/1873-3468.14447.<\/em> Editor\u2019s choice-Journal cover<\/u>.<\/p>\n Wenxuan Xu, Yan Yan, Irina Artsimovich, David Dunlap and Laura Finzi<\/u>, \u201cPositive supercoiling favors transcription elongation through lac repressor-mediated DNA loops\u201d, Nucleic Acids Research<\/em> 50<\/em><\/strong>, 2826-2835, 2022.<\/p>\n Yan Yan, Wenxuan Xu, Sandip Kumar, Alexander Zhang, Fenfei Leng, David D. Dunlap and Laura Finzi<\/u>, \u201cNegative DNA supercoiling makes protein-mediated looping deterministic and ergodic within the bacterial doubling time\u201d, Nucleic Acids Research <\/em>2021, 49<\/strong>(20) 11550-11559; \u00a0<\/strong>https:\/\/doi.org\/10.1093\/nar\/gkab946<\/a>.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Endowed Chair-Med Biophysics Email: lfinzi@clemson.edu Brief Bio Laura Finzi is a professor of biophysics and the Dr. Waenard L. Miller, Jr. \u201969 and Sheila M. Miller Endowed Chair in Medical Biophysics in the Department of Physics and Astronomy. She is a Fellow of the America Physical Society and on the Editorial Board of Biophysical Reviews. […]<\/p>\n","protected":false},"author":32,"featured_media":1680,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\r\n\r\nEndowed Chair-Med Biophysics\r\n\r\nEmail: lfinzi@clemson.edu\r\nBrief Bio<\/strong><\/h3>\r\nLaura Finzi is a professor of biophysics and the Dr. Waenard L. Miller, Jr. \u201969 and Sheila M. Miller Endowed Chair in Medical Biophysics in the Department of Physics and Astronomy. She is a Fellow of the America Physical Society and on the Editorial Board of Biophysical Reviews. She received a Laurea in Industrial Chemistry from the University of Bologna, Italy and a PhD in Chemistry from the University of New Mexico. She was a postdoctoral fellow with Dr. Carlos Bustamante at The Institute of Molecular Biology in Eugene, OR, and with Dr. Jeff Gelles at Brandeis University. She is recognized internationally for her contributions to the understanding of DNA mechanics, topology and physical interactions relevant to transcription regulation.\r\n
Research Interests<\/strong><\/h3>\r\nDr. Finzi\u2019s interests lie at the intersection between physics, chemistry and biology. How does the structure, topology and physical phase of DNA affect transcription and its interaction with proteins? Using single-molecule approaches, Dr. Finzi\u2019s group has unveiled the fundamental mechanisms of genetic switches, the key parameters regulating the strength of protein roadblocks to transcription and the structural features permitting transcription recycling. The knowledge produced by her group about molecular mechanisms is important to understand human disease, guide drug design and advance personalized medicine.\r\n
Publications<\/strong><\/h3>\r\nJin Qian, Bing Wang, Irina Artsimovitch, David Dunlap, Laura Finzi<\/u> \u201cForce and the \u03b1-C-terminal domains bias RNA polymerase recycling\u201d, Nature Comm<\/em>. https:\/\/www.nature.com\/articles\/s41467-024-51603-3<\/a>. DOI: 10.1038\/s41467-024-51603-3\r\n\r\nJin Qian, Allison Cartee, Wenxuan Xu, Yan Yan, Bing Wang, Irina Artsimovitch, David Dunlap, Laura Finzi<\/u> \u201cReciprocating RNA Polymerase batters through roadblocks\u201d Nature Comm<\/em>., doi:<\/strong>10.1038\/s41467-024-47531-x.\r\n\r\nYue Lu, Gustavo Borjas, Cristine Hendrickson, Zsuzsanna V\u00f6r\u00f6s, David Dunlap, Keith Shearwin and Laura Finzi<\/u>, \u201cProteins mediating different DNA topologies block RNAP elongation with different efficiency.\u201d FEBS Letters<\/em>, 2022, 596<\/strong>, 1994-2006; doi<\/strong>:10.1002\/1873-3468.14447.<\/em> Editor\u2019s choice-Journal cover<\/u>.\r\n\r\nWenxuan Xu, Yan Yan, Irina Artsimovich, David Dunlap and Laura Finzi<\/u>, \u201cPositive supercoiling favors transcription elongation through lac repressor-mediated DNA loops\u201d, Nucleic Acids Research<\/em> 50<\/em><\/strong>, 2826-2835, 2022.\r\n\r\nYan Yan, Wenxuan Xu, Sandip Kumar, Alexander Zhang, Fenfei Leng, David D. Dunlap and Laura Finzi<\/u>, \u201cNegative DNA supercoiling makes protein-mediated looping deterministic and ergodic within the bacterial doubling time\u201d, Nucleic Acids Research <\/em>2021, 49<\/strong>(20) 11550-11559; \u00a0<\/strong>https:\/\/doi.org\/10.1093\/nar\/gkab946<\/a>.","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[12,10],"tags":[],"class_list":["post-1681","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculty","category-people"],"_links":{"self":[{"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/posts\/1681","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/users\/32"}],"replies":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/comments?post=1681"}],"version-history":[{"count":0,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/posts\/1681\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/media\/1680"}],"wp:attachment":[{"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/media?parent=1681"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/categories?post=1681"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/tags?post=1681"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}