![\"ChrisFarrell\"](\"https:\/\/scienceweb.clemson.edu\/chg\/wp-content\/uploads\/sites\/4\/2023\/10\/ChrisFarrell-261x300.jpg\" "\\"ChrisFarrell\\"")
Chris Farrell<\/p><\/div><\/p>\n
Assistant Professor, School of Nursing<\/strong><\/p>\n Email: clf@clemson.edu<\/p>\n Dr. Christopher Farrell is an assistant professor in the Healthcare Genetics and Genomics (HCG) program at Clemson University.\u00a0 Prior to joining Clemson University, Dr. Farrell worked in the pharmaceutical industry for several years on vaccines and monoclonal antibody therapies.\u00a0 \u00a0He then received his Ph.D. in Biomedical Sciences from the University of South Carolina. \u00a0He has taught in the healthcare programs of several institutions such as Presbyterian College, Manchester University, and Campbell University.\u00a0 His area of research is cancer genetics, cancer education in rural communities, pharmacogenomics education and the study of inherited disorders such as Aarskog-Scott and Fraser syndromes.<\/p>\n Multi-drug resistance (MDR) is a serious complication in the treatment of cancer patients.\u00a0 MDR can become an obstacle to chemotherapy treatment in solid tumors of any stage but is more commonly associated with late stage and\/or aggressive tumors.\u00a0 Patients with MDR tumors have a poor prognosis compared to patients with a tumor which is responsive to chemotherapy.\u00a0 A patient\u2019s tumor can develop MDR before or after the initiation of chemotherapy treatment.\u00a0 The cause of MDR after the initiation of chemotherapy is well understood, but it is not known how tumors develop MDR before chemotherapy treatment.\u00a0\u00a0 With identifying a connection in MDR tumors of chemotherapy-na\u00efve patients, we hope to discover biomarkers that will lead to better treatment plans for patients who are starting the initial chemotherapy treatment.<\/p>\n Farrell CL<\/strong> et al. “Assessing the pharmacy students’ knowledge of genetic counseling with genetic variants that are associated with inherited disease.”\u00a0Currents in Pharmacy Teaching and Learning<\/em>\u00a0(2023).<\/p>\n Meaddough EL, Sarasua SM, Fasolino TK, Farrell CL.<\/strong> The impact of pharmacogenetic testing in patients exposed to polypharmacy: a scoping review. The Pharmacogenomics Journal<\/em>.\u00a0 2021 Jun 17:1-4<\/p>\n Chart NA, Kisor DF, and Farrell CL<\/strong>. “Defining the role of pharmacists in medication-related genetic counseling.”\u00a0Personalized Medicine<\/em>\u00a018.05 (2021): 509-522.<\/p>\n Kisor DF & Farrell CL<\/strong>. Expanding Pharmacist and Student Pharmacist Access to Genetics\/Genomics\/Pharmacogenomics Competency Education. Journal of medical education and curricular development<\/em>. (2019):2382120519834325.<\/p>\n Kisor DF, Calinski DM, & Farrell CL<\/strong>. “Beyond the didactic lecture: pharmacogenomics in pharmacy education.” Precision Medicine<\/em> (2018): 9-12.<\/p>\n Shull AY & Farrell CL<\/strong>. “\u2018Et tu, inhibitor?\u2019: the potential for HIV inhibitors to prime P-gp-mediated chemoresistance in cancer.” Future Sci OA (2017): 23: 4<\/p>\n Caudle, N & Farrell C<\/strong>. \u201cCommunity Education of Personalized Breast Cancer Therapy Utilizing Students of Healthcare Profession\u201d Clinical Medicine Research<\/em>, 2017: 6(5):157-163.<\/p>\n Beasley S, Buckhaults PJ, Pedigo NG, & Farrell CL<\/strong>. Association of FGD1 polymorphisms with early-onset breast cancer.\u00a0Oncology letters<\/em>,\u00a02016: 2<\/em>(3), 2071-2077.<\/p>\n Pedigo NG, Van Delden D, Walters L, & Farrell CL<\/strong>. \u201cMinireview: Role of genetic changes of faciogenital dysplasia protein 1 in human disease.\u201d Physiological Genomics<\/em> July 2016: 48\u00a0(7)\u00a0446-454<\/p>\n Kisor D, Smith HE, Grace E, Johnson SG, Weitzel KW, & Farrell CL<\/strong>.\u00a0 \u201cThe DNA of pharmacy education.\u201d American Association of Colleges of Pharmacy (AACP<\/em>) on the Center for the Advancement of Pharmacy Education (CAPE) Website (Published on the AACP<\/em> Website in March 2016)<\/p>\n Farrell CL,<\/strong> Pedigo NP, & Messersmith AR. “Application of genomic principles to pharmacotherapy of cancer.”\u00a0American journal of pharmaceutical education<\/em>\u00a078.3 (2014).<\/p>\n Birtwistle MR, Berrong Z, Duff K, Cloessner E, Tidwell J, Clendenning M, Wilkerson B, Farrell CL<\/strong>, Bunz F,\u00a0 Jai H, Michael Shtutman M, Creek KE, Banister. CE, Buckhaults PJ. \u201cTranscriptomes and shRNA suppressors in a TP53 allele\u2013specific model of early-onset colon cancer in African Americans.\u201d Molecular Cancer Research<\/em> 12.7 (2014): 1029-1041<\/p>\n Farrell CL<\/strong>, Goodbar NH, Freeland KN, Grace EG, Buckhaults PJ, & Moore KG. \u201cClinical application of pharmacogenomics through clinical exercises and online resources.\u201d Currents in Pharmacy Teaching and Learning<\/em> 6.4 (2014): 571-576.<\/p>\n Farrell CL<\/strong>. “Decreasing Drug Resistance through modulation\/inhibition of the p-glycoprotein.” Austin J Pharmacol Ther<\/em> 2.6 (2014): 2.<\/p>\n Shull AY,\u00a0 Clendenning ML, Sampa Ghoshal-Gupta S, & Farrell CL<\/strong>, Vangapandu, HV,\u00a0 Dudas, L, Wilkerson, BJ, Buckhaults, PJ.\u00a0 “Somatic mutations, allele loss, and DNA methylation of the Cub and Sushi Multiple Domains 1 (CSMD1) gene reveals association with early age of diagnosis in colorectal cancer patients.”\u00a0PloS one<\/em>\u00a08.3 (2013): e58731.<\/p>\n Lin Y, Buckhaults PJ, Lee JL, Xiong H, Farrell C<\/strong>, Podolsky RH, Schade RR, Dynan WS. \u00a0“Association of the actin-binding protein transgelin with lymph node metastasis in human colorectal cancer.”\u00a0Neoplasia<\/em>\u00a011.9 (2009): 864-IN5.<\/p>\n Meeh, PF, Farrell CL<\/strong>, Croshaw R, Crimm H, Miller SK, Oroian D, Kowli S, Zhu J, Carver W, Wu W, Pena E, Buckhaults PJ. \u00a0“A gene expression classifier of node-positive colorectal cancer.”\u00a0Neoplasia<\/em>\u00a011.10 (2009): 1074-IN12.<\/p>\n Farrell CL<\/strong>, Crimm H, Meeh P, Croshaw R, Barbar TD, Vandersteenhoven JJ, Butler W, Buckhaults P. \u00a0“Somatic mutations to CSMD1 in colorectal adenocarcinomas.”\u00a0Cancer biology & therapy<\/em>\u00a07.4 (2008): 609-613<\/p>\n Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber T, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P<\/strong>, Farrell C<\/strong>, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE.\u00a0 “The consensus coding sequences of human breast and colorectal cancers.”\u00a0Science<\/em>\u00a0314.5797 (2006): 268-274.<\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Assistant Professor, School of Nursing Email: clf@clemson.edu Biosketch Dr. Christopher Farrell is an assistant professor in the Healthcare Genetics and Genomics (HCG) program at Clemson University.\u00a0 Prior to joining Clemson University, Dr. Farrell worked in the pharmaceutical industry for several years on vaccines and monoclonal antibody therapies.\u00a0 \u00a0He then received his Ph.D. in Biomedical Sciences […]<\/p>\n","protected":false},"author":32,"featured_media":1507,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[caption id=\"attachment_1507\" align=\"alignright\" width=\"261\"]Biosketch<\/strong><\/h2>\n
Research<\/strong><\/h3>\n
Publications<\/strong><\/h3>\n
Chris Farrell[\/caption]\r\n\r\nAssistant Professor, School of Nursing<\/strong>\r\n\r\nEmail: clf@clemson.edu\r\nBiosketch<\/strong><\/h3>\r\nDr. Christopher Farrell is an assistant professor in the Healthcare Genetics and Genomics (HCG) program at Clemson University.\u00a0 Prior to joining Clemson University, Dr. Farrell worked in the pharmaceutical industry for several years on vaccines and monoclonal antibody therapies.\u00a0 \u00a0He then received his Ph.D. in Biomedical Sciences from the University of South Carolina. \u00a0He has taught in the healthcare programs of several institutions such as Presbyterian College, Manchester University, and Campbell University.\u00a0 His area of research is cancer genetics, cancer education in rural communities, pharmacogenomics education and the study of inherited disorders such as Aarskog-Scott and Fraser syndromes.\r\n
Research<\/strong><\/h3>\r\nMulti-drug resistance (MDR) is a serious complication in the treatment of cancer patients.\u00a0 MDR can become an obstacle to chemotherapy treatment in solid tumors of any stage but is more commonly associated with late stage and\/or aggressive tumors.\u00a0 Patients with MDR tumors have a poor prognosis compared to patients with a tumor which is responsive to chemotherapy.\u00a0 A patient\u2019s tumor can develop MDR before or after the initiation of chemotherapy treatment.\u00a0 The cause of MDR after the initiation of chemotherapy is well understood, but it is not known how tumors develop MDR before chemotherapy treatment.\u00a0\u00a0 With identifying a connection in MDR tumors of chemotherapy-na\u00efve patients, we hope to discover biomarkers that will lead to better treatment plans for patients who are starting the initial chemotherapy treatment.\r\n
Publications<\/strong><\/h3>\r\nFarrell CL<\/strong> et al. \"Assessing the pharmacy students' knowledge of genetic counseling with genetic variants that are associated with inherited disease.\"\u00a0Currents in Pharmacy Teaching and Learning<\/em>\u00a0(2023).\r\n\r\nMeaddough EL, Sarasua SM, Fasolino TK, Farrell CL.<\/strong> The impact of pharmacogenetic testing in patients exposed to polypharmacy: a scoping review. The Pharmacogenomics Journal<\/em>.\u00a0 2021 Jun 17:1-4\r\n\r\nChart NA, Kisor DF, and Farrell CL<\/strong>. \"Defining the role of pharmacists in medication-related genetic counseling.\"\u00a0Personalized Medicine<\/em>\u00a018.05 (2021): 509-522.\r\n\r\nKisor DF & Farrell CL<\/strong>. Expanding Pharmacist and Student Pharmacist Access to Genetics\/Genomics\/Pharmacogenomics Competency Education. Journal of medical education and curricular development<\/em>. (2019):2382120519834325.\r\n\r\nKisor DF, Calinski DM, & Farrell CL<\/strong>. \"Beyond the didactic lecture: pharmacogenomics in pharmacy education.\" Precision Medicine<\/em> (2018): 9-12.\r\n\r\nShull AY & Farrell CL<\/strong>. \"\u2018Et tu, inhibitor?\u2019: the potential for HIV inhibitors to prime P-gp-mediated chemoresistance in cancer.\" Future Sci OA (2017): 23: 4\r\n\r\nCaudle, N & Farrell C<\/strong>. \u201cCommunity Education of Personalized Breast Cancer Therapy Utilizing Students of Healthcare Profession\u201d Clinical Medicine Research<\/em>, 2017: 6(5):157-163.\r\n\r\nBeasley S, Buckhaults PJ, Pedigo NG, & Farrell CL<\/strong>. Association of FGD1 polymorphisms with early-onset breast cancer.\u00a0Oncology letters<\/em>,\u00a02016: 2<\/em>(3), 2071-2077.\r\n\r\nPedigo NG, Van Delden D, Walters L, & Farrell CL<\/strong>. \u201cMinireview: Role of genetic changes of faciogenital dysplasia protein 1 in human disease.\u201d Physiological Genomics<\/em> July 2016: 48\u00a0(7)\u00a0446-454\r\n\r\nKisor D, Smith HE, Grace E, Johnson SG, Weitzel KW, & Farrell CL<\/strong>.\u00a0 \u201cThe DNA of pharmacy education.\u201d American Association of Colleges of Pharmacy (AACP<\/em>) on the Center for the Advancement of Pharmacy Education (CAPE) Website (Published on the AACP<\/em> Website in March 2016)\r\n\r\nFarrell CL,<\/strong> Pedigo NP, & Messersmith AR. \"Application of genomic principles to pharmacotherapy of cancer.\"\u00a0American journal of pharmaceutical education<\/em>\u00a078.3 (2014).\r\n\r\nBirtwistle MR, Berrong Z, Duff K, Cloessner E, Tidwell J, Clendenning M, Wilkerson B, Farrell CL<\/strong>, Bunz F,\u00a0 Jai H, Michael Shtutman M, Creek KE, Banister. CE, Buckhaults PJ. \u201cTranscriptomes and shRNA suppressors in a TP53 allele\u2013specific model of early-onset colon cancer in African Americans.\u201d Molecular Cancer Research<\/em> 12.7 (2014): 1029-1041\r\n\r\nFarrell CL<\/strong>, Goodbar NH, Freeland KN, Grace EG, Buckhaults PJ, & Moore KG. \u201cClinical application of pharmacogenomics through clinical exercises and online resources.\u201d Currents in Pharmacy Teaching and Learning<\/em> 6.4 (2014): 571-576.\r\n\r\nFarrell CL<\/strong>. \"Decreasing Drug Resistance through modulation\/inhibition of the p-glycoprotein.\" Austin J Pharmacol Ther<\/em> 2.6 (2014): 2.\r\n\r\nShull AY,\u00a0 Clendenning ML, Sampa Ghoshal-Gupta S, & Farrell CL<\/strong>, Vangapandu, HV,\u00a0 Dudas, L, Wilkerson, BJ, Buckhaults, PJ.\u00a0 \"Somatic mutations, allele loss, and DNA methylation of the Cub and Sushi Multiple Domains 1 (CSMD1) gene reveals association with early age of diagnosis in colorectal cancer patients.\"\u00a0PloS one<\/em>\u00a08.3 (2013): e58731.\r\n\r\nLin Y, Buckhaults PJ, Lee JL, Xiong H, Farrell C<\/strong>, Podolsky RH, Schade RR, Dynan WS. \u00a0\"Association of the actin-binding protein transgelin with lymph node metastasis in human colorectal cancer.\"\u00a0Neoplasia<\/em>\u00a011.9 (2009): 864-IN5.\r\n\r\nMeeh, PF, Farrell CL<\/strong>, Croshaw R, Crimm H, Miller SK, Oroian D, Kowli S, Zhu J, Carver W, Wu W, Pena E, Buckhaults PJ. \u00a0\"A gene expression classifier of node-positive colorectal cancer.\"\u00a0Neoplasia<\/em>\u00a011.10 (2009): 1074-IN12.\r\n\r\nFarrell CL<\/strong>, Crimm H, Meeh P, Croshaw R, Barbar TD, Vandersteenhoven JJ, Butler W, Buckhaults P. \u00a0\"Somatic mutations to CSMD1 in colorectal adenocarcinomas.\"\u00a0Cancer biology & therapy<\/em>\u00a07.4 (2008): 609-613\r\n\r\nSjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber T, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P<\/strong>, Farrell C<\/strong>, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE.\u00a0 \"The consensus coding sequences of human breast and colorectal cancers.\"\u00a0Science<\/em>\u00a0314.5797 (2006): 268-274.\r\n\r\n ","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[12],"tags":[],"class_list":["post-1508","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculty"],"_links":{"self":[{"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/posts\/1508","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/users\/32"}],"replies":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/comments?post=1508"}],"version-history":[{"count":0,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/posts\/1508\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/media\/1507"}],"wp:attachment":[{"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/media?parent=1508"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/categories?post=1508"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/ihg\/wp-json\/wp\/v2\/tags?post=1508"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}