Email: monirem@clemson.edu<\/p>\n
![\"Monireh](\"https:\/\/scienceweb.clemson.edu\/chg\/wp-content\/uploads\/sites\/4\/2023\/04\/monireh-mohammadpanah-1-g-scaled.jpg\" "\\"Monireh")
<\/a>Monireh Mohammadpanah<\/p><\/div>\n
Biosketch<\/strong><\/h3>\n\u200bMonireh received her B.S. in Cellular and Molecular Biology from Shahid Chamran University and her M.S. in Molecular Genetics from Yazd University, Iran. Her master’s research focused on the epigenetic regulation of inflammatory genes in patients with coronary atherosclerosis. She also\u00a0designed and optimized liposomal nanocarriers for drug delivery applications in breast cancer.\u00a0In January 2022, she joined the lab of Dr. Andrei Alexandrov at the Clemson Center for Human Genetics as a Ph.D. student in Genetics. Her doctoral research focuses on developing and applying high-throughput forward genetic approaches to identify pathways involved in human RNA processing and surveillance.\u00a0<\/p>\n
Research<\/strong><\/h3>\nIn Dr. Alexandrov’s lab, she identified and studied components of disease-associated human pathways involved in RNA biogenesis, regulation, and surveillance using biochemical approaches, high-throughput forward genetics, functional genomics, CRISPR-based approaches, and fluorescence-activated cell sorting (FACS). Her research focuses on cancer-associated human RNA pathways, specifically the regulation of the human cancer-associated nuclear long non-coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1).<\/p>\n
She has developed novel approaches, such as Mirror and iterative screening of genome-wide guide RNA omission libraries, which enabled her to identify novel components of human pathways acting on the long non-coding RNA MALAT1, as well as the RNase MRP and RNase P control (RMPPc) pathway. The RMPPc pathway controls non-canonical 3\u2032-end processing of the lncRNAs MALAT1 and MEN-\u03b2, post-transcriptional processing of internal transcribed spacers in pre-rRNA, and processing of 5\u2032 leader sequences in pre-tRNA.<\/p>\n
She is also one of the inventors on the U.S. patent, \u201cBacteria-Free Approach for Expressing Nucleic Acids and Proteins in Eukaryotic Cells.\u201d<\/p>\n
Publications<\/strong><\/h3>\nTRNAU1AP and PRPF39 Establish Integrated Control over Processing of Most Abundant Human Non-coding RNAs.\u00a0Nature Communications<\/strong>,\u00a0<\/strong>2026.\u00a0https:\/\/www.nature.com\/articles\/s41467-026-74036-6<\/a><\/p>\nIdentification of Human Pathways Acting on Nuclear Non-Coding RNAs Using the Mirror Forward Genetic Approach.\u00a0Nature Communications<\/strong>, 2025.\u00a0https:\/\/doi.org\/10.1038\/s41467-025-59998-3<\/a><\/p>\nIdentification of RMP24 and RMP64, Human Ribonuclease MRP-Specific Protein Components.\u00a0Cell Reports<\/strong>, 2025.\u00a0https:\/\/doi.org\/10.1016\/j.celrep.2025.115752<\/a><\/p>\nBacteria-Free Approach for Expressing Nucleic Acids and Proteins in Eukaryotic Cells.\u00a0U.S. Patent<\/strong>\u00a0Application US20250163437A1, 2024.\u00a0https:\/\/patents.google.com\/patent\/US20250163437A1\/en<\/a><\/p>\nRegulatory and Non-Coding RNAs meeting, Cold Spring Harbor, NY (April 2026).<\/p>\n
Panah et al.,\u00a0<\/strong>\u201cTRNAU1AP and PRPF39 Establish Integrated Control over Processing of Most Abundant Human Non-coding RNAs.\u201d<\/p>\n3rd<\/sup>\u00a0Annual RNA Symposium, University of California Riverside, CA (October 2025).<\/p>\nPanah et al.,\u00a0<\/strong>\u201cIntegrated Control of Human RNase P and RNase MRP (RMPPc) Identified by Genome-wide Screening\u201d (best poster award<\/em>).<\/p>\nThe 15th<\/sup>\u00a0Eukaryotic mRNA Processing meeting, Cold Spring Harbor, NY (August 2025).<\/p>\nPanah et al.,\u00a0<\/strong>\u201cIdentification of Pathway-Specific Surfaces in Human RNA Exosome Using Deep Mutational Scanning.<\/p>\nThe 30th<\/sup>\u00a0Annual Meeting of the RNA Society, San Diego, CA (May 2025).<\/p>\nPanah et al.,\u00a0<\/strong>\u201cIdentification of Pathway-Specific Surfaces in Human RNA Exosome Using Deep Mutational Scanning.<\/p>\n <\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
Graduate Student Email: monirem@clemson.edu Biosketch \u200bMonireh received her B.S. in Cellular and Molecular Biology from Shahid Chamran University and her M.S. in Molecular Genetics from Yazd University, Iran. Her master’s research focused on the epigenetic regulation of inflammatory genes in patients with coronary atherosclerosis. She also\u00a0designed and optimized liposomal nanocarriers for drug delivery applications in […]<\/p>\n","protected":false},"author":13,"featured_media":1335,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"
Graduate Student<\/strong><\/p>Email: monirem@clemson.edu<\/p>[caption id=\"attachment_1335\" align=\"alignright\" width=\"240\"]![\"Monireh](\"https:\/\/scienceweb.clemson.edu\/chg\/wp-content\/uploads\/sites\/4\/2023\/04\/monireh-mohammadpanah-1-g-240x300.jpg\" "\\"Monireh")
<\/a> Monireh Mohammadpanah[\/caption]Biosketch<\/strong><\/h3>Monireh obtained her Bachelor degree in Cellular and Molecular Biology from Chamran University and Master degree in Molecular Genetics from Yazd University in Iran. Her research focused on epigenetic regulation of atherosclerosis-associated gene promoters. She then joined an Internship program in Meybod Genetic Research Center where she studied miRNAs expression in human neurologic disorders. In 2020, <\/em>she joined Medical Nanotechnology<\/em> and Tissue Engineering Research\u00a0Center<\/em> as a research assistant to improve nanoparticle drug delivery in breast cancer.<\/p>Research<\/strong><\/h3>In January 2022, she joined the lab of Dr. Andrei Alexandrov at the Clemson Center for Human Genetics as a doctoral student. Her research focuses on the validation of factors regulating human metastasis-associated long non-coding RNA MALAT1 and the development of ultra-high throughput functional screening technology to map potential druggable sites within multi-functional essential human proteins. Her second project studies the pathway of nonsense-mediated mRNA degradation that is involved in hundreds of human genetic disorders.<\/p>
Publications<\/strong><\/h3>Identification of Human Pathways Acting on Nuclear Non-Coding RNAs Using the Mirror Forward Genetic Approach. Nature Communications, 2025. https:\/\/doi.org\/10.1038\/s41467-025-59998-3<\/a><\/p>Identification of RMP24 and RMP64, Human Ribonuclease MRP-Specific Protein Components. Cell Reports, 2025. https:\/\/doi.org\/10.1016\/j.celrep.2025.115752<\/a><\/p>Identification of Pathway-Specific Surfaces in the Human RNA Exosome Using Deep Mutational Scanning. Eukaryotic mRNA Processing, CSHL, 2025 \u2014 Poster presentation.<\/p>
Identification of Pathway-Specific Surfaces in the Human RNA Exosome Using Deep Mutational Scanning. RNA Society Annual Meeting, San Diego, 2025 \u2014 Poster presentation.<\/p>
In Dr. Alexandrov’s lab, she identified and studied components of disease-associated human pathways involved in RNA biogenesis, regulation, and surveillance using biochemical approaches, high-throughput forward genetics, functional genomics, CRISPR-based approaches, and fluorescence-activated cell sorting (FACS). Her research focuses on cancer-associated human RNA pathways, specifically the regulation of the human cancer-associated nuclear long non-coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1).<\/p>\n
She has developed novel approaches, such as Mirror and iterative screening of genome-wide guide RNA omission libraries, which enabled her to identify novel components of human pathways acting on the long non-coding RNA MALAT1, as well as the RNase MRP and RNase P control (RMPPc) pathway. The RMPPc pathway controls non-canonical 3\u2032-end processing of the lncRNAs MALAT1 and MEN-\u03b2, post-transcriptional processing of internal transcribed spacers in pre-rRNA, and processing of 5\u2032 leader sequences in pre-tRNA.<\/p>\n
She is also one of the inventors on the U.S. patent, \u201cBacteria-Free Approach for Expressing Nucleic Acids and Proteins in Eukaryotic Cells.\u201d<\/p>\n
Publications<\/strong><\/h3>\nTRNAU1AP and PRPF39 Establish Integrated Control over Processing of Most Abundant Human Non-coding RNAs.\u00a0Nature Communications<\/strong>,\u00a0<\/strong>2026.\u00a0https:\/\/www.nature.com\/articles\/s41467-026-74036-6<\/a><\/p>\nIdentification of Human Pathways Acting on Nuclear Non-Coding RNAs Using the Mirror Forward Genetic Approach.\u00a0Nature Communications<\/strong>, 2025.\u00a0https:\/\/doi.org\/10.1038\/s41467-025-59998-3<\/a><\/p>\nIdentification of RMP24 and RMP64, Human Ribonuclease MRP-Specific Protein Components.\u00a0Cell Reports<\/strong>, 2025.\u00a0https:\/\/doi.org\/10.1016\/j.celrep.2025.115752<\/a><\/p>\nBacteria-Free Approach for Expressing Nucleic Acids and Proteins in Eukaryotic Cells.\u00a0U.S. Patent<\/strong>\u00a0Application US20250163437A1, 2024.\u00a0https:\/\/patents.google.com\/patent\/US20250163437A1\/en<\/a><\/p>\nRegulatory and Non-Coding RNAs meeting, Cold Spring Harbor, NY (April 2026).<\/p>\n
Panah et al.,\u00a0<\/strong>\u201cTRNAU1AP and PRPF39 Establish Integrated Control over Processing of Most Abundant Human Non-coding RNAs.\u201d<\/p>\n3rd<\/sup>\u00a0Annual RNA Symposium, University of California Riverside, CA (October 2025).<\/p>\nPanah et al.,\u00a0<\/strong>\u201cIntegrated Control of Human RNase P and RNase MRP (RMPPc) Identified by Genome-wide Screening\u201d (best poster award<\/em>).<\/p>\nThe 15th<\/sup>\u00a0Eukaryotic mRNA Processing meeting, Cold Spring Harbor, NY (August 2025).<\/p>\nPanah et al.,\u00a0<\/strong>\u201cIdentification of Pathway-Specific Surfaces in Human RNA Exosome Using Deep Mutational Scanning.<\/p>\nThe 30th<\/sup>\u00a0Annual Meeting of the RNA Society, San Diego, CA (May 2025).<\/p>\nPanah et al.,\u00a0<\/strong>\u201cIdentification of Pathway-Specific Surfaces in Human RNA Exosome Using Deep Mutational Scanning.<\/p>\n <\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
Graduate Student Email: monirem@clemson.edu Biosketch \u200bMonireh received her B.S. in Cellular and Molecular Biology from Shahid Chamran University and her M.S. in Molecular Genetics from Yazd University, Iran. Her master’s research focused on the epigenetic regulation of inflammatory genes in patients with coronary atherosclerosis. She also\u00a0designed and optimized liposomal nanocarriers for drug delivery applications in […]<\/p>\n","protected":false},"author":13,"featured_media":1335,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"
Graduate Student<\/strong><\/p>Email: monirem@clemson.edu<\/p>[caption id=\"attachment_1335\" align=\"alignright\" width=\"240\"]<\/a> Monireh Mohammadpanah[\/caption]Biosketch<\/strong><\/h3>Monireh obtained her Bachelor degree in Cellular and Molecular Biology from Chamran University and Master degree in Molecular Genetics from Yazd University in Iran. Her research focused on epigenetic regulation of atherosclerosis-associated gene promoters. She then joined an Internship program in Meybod Genetic Research Center where she studied miRNAs expression in human neurologic disorders. In 2020, <\/em>she joined Medical Nanotechnology<\/em> and Tissue Engineering Research\u00a0Center<\/em> as a research assistant to improve nanoparticle drug delivery in breast cancer.<\/p>Research<\/strong><\/h3>In January 2022, she joined the lab of Dr. Andrei Alexandrov at the Clemson Center for Human Genetics as a doctoral student. Her research focuses on the validation of factors regulating human metastasis-associated long non-coding RNA MALAT1 and the development of ultra-high throughput functional screening technology to map potential druggable sites within multi-functional essential human proteins. Her second project studies the pathway of nonsense-mediated mRNA degradation that is involved in hundreds of human genetic disorders.<\/p>
Publications<\/strong><\/h3>Identification of Human Pathways Acting on Nuclear Non-Coding RNAs Using the Mirror Forward Genetic Approach. Nature Communications, 2025. https:\/\/doi.org\/10.1038\/s41467-025-59998-3<\/a><\/p>Identification of RMP24 and RMP64, Human Ribonuclease MRP-Specific Protein Components. Cell Reports, 2025. https:\/\/doi.org\/10.1016\/j.celrep.2025.115752<\/a><\/p>Identification of Pathway-Specific Surfaces in the Human RNA Exosome Using Deep Mutational Scanning. Eukaryotic mRNA Processing, CSHL, 2025 \u2014 Poster presentation.<\/p>
Identification of Pathway-Specific Surfaces in the Human RNA Exosome Using Deep Mutational Scanning. RNA Society Annual Meeting, San Diego, 2025 \u2014 Poster presentation.<\/p>
Identification of Human Pathways Acting on Nuclear Non-Coding RNAs Using the Mirror Forward Genetic Approach.\u00a0Nature Communications<\/strong>, 2025.\u00a0https:\/\/doi.org\/10.1038\/s41467-025-59998-3<\/a><\/p>\n Identification of RMP24 and RMP64, Human Ribonuclease MRP-Specific Protein Components.\u00a0Cell Reports<\/strong>, 2025.\u00a0https:\/\/doi.org\/10.1016\/j.celrep.2025.115752<\/a><\/p>\n Bacteria-Free Approach for Expressing Nucleic Acids and Proteins in Eukaryotic Cells.\u00a0U.S. Patent<\/strong>\u00a0Application US20250163437A1, 2024.\u00a0https:\/\/patents.google.com\/patent\/US20250163437A1\/en<\/a><\/p>\n Regulatory and Non-Coding RNAs meeting, Cold Spring Harbor, NY (April 2026).<\/p>\n Panah et al.,\u00a0<\/strong>\u201cTRNAU1AP and PRPF39 Establish Integrated Control over Processing of Most Abundant Human Non-coding RNAs.\u201d<\/p>\n 3rd<\/sup>\u00a0Annual RNA Symposium, University of California Riverside, CA (October 2025).<\/p>\n Panah et al.,\u00a0<\/strong>\u201cIntegrated Control of Human RNase P and RNase MRP (RMPPc) Identified by Genome-wide Screening\u201d (best poster award<\/em>).<\/p>\n The 15th<\/sup>\u00a0Eukaryotic mRNA Processing meeting, Cold Spring Harbor, NY (August 2025).<\/p>\n Panah et al.,\u00a0<\/strong>\u201cIdentification of Pathway-Specific Surfaces in Human RNA Exosome Using Deep Mutational Scanning.<\/p>\n The 30th<\/sup>\u00a0Annual Meeting of the RNA Society, San Diego, CA (May 2025).<\/p>\n Panah et al.,\u00a0<\/strong>\u201cIdentification of Pathway-Specific Surfaces in Human RNA Exosome Using Deep Mutational Scanning.<\/p>\n <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Graduate Student Email: monirem@clemson.edu Biosketch \u200bMonireh received her B.S. in Cellular and Molecular Biology from Shahid Chamran University and her M.S. in Molecular Genetics from Yazd University, Iran. Her master’s research focused on the epigenetic regulation of inflammatory genes in patients with coronary atherosclerosis. She also\u00a0designed and optimized liposomal nanocarriers for drug delivery applications in […]<\/p>\n","protected":false},"author":13,"featured_media":1335,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":" Graduate Student<\/strong><\/p> Email: monirem@clemson.edu<\/p>[caption id=\"attachment_1335\" align=\"alignright\" width=\"240\"] Monireh obtained her Bachelor degree in Cellular and Molecular Biology from Chamran University and Master degree in Molecular Genetics from Yazd University in Iran. Her research focused on epigenetic regulation of atherosclerosis-associated gene promoters. She then joined an Internship program in Meybod Genetic Research Center where she studied miRNAs expression in human neurologic disorders. In 2020, <\/em>she joined Medical Nanotechnology<\/em> and Tissue Engineering Research\u00a0Center<\/em> as a research assistant to improve nanoparticle drug delivery in breast cancer.<\/p> In January 2022, she joined the lab of Dr. Andrei Alexandrov at the Clemson Center for Human Genetics as a doctoral student. Her research focuses on the validation of factors regulating human metastasis-associated long non-coding RNA MALAT1 and the development of ultra-high throughput functional screening technology to map potential druggable sites within multi-functional essential human proteins. Her second project studies the pathway of nonsense-mediated mRNA degradation that is involved in hundreds of human genetic disorders.<\/p> Identification of Human Pathways Acting on Nuclear Non-Coding RNAs Using the Mirror Forward Genetic Approach. Nature Communications, 2025. https:\/\/doi.org\/10.1038\/s41467-025-59998-3<\/a><\/p> Identification of RMP24 and RMP64, Human Ribonuclease MRP-Specific Protein Components. Cell Reports, 2025. https:\/\/doi.org\/10.1016\/j.celrep.2025.115752<\/a><\/p> Identification of Pathway-Specific Surfaces in the Human RNA Exosome Using Deep Mutational Scanning. Eukaryotic mRNA Processing, CSHL, 2025 \u2014 Poster presentation.<\/p> Identification of Pathway-Specific Surfaces in the Human RNA Exosome Using Deep Mutational Scanning. RNA Society Annual Meeting, San Diego, 2025 \u2014 Poster presentation.<\/p><\/a> Monireh Mohammadpanah[\/caption]Biosketch<\/strong><\/h3>
Research<\/strong><\/h3>
Publications<\/strong><\/h3>