{"id":98,"date":"2024-12-11T23:17:23","date_gmt":"2024-12-12T04:17:23","guid":{"rendered":"https:\/\/scienceweb.clemson.edu\/gso\/?p=98"},"modified":"2024-12-11T23:25:08","modified_gmt":"2024-12-12T04:25:08","slug":"islet-amyloid-polypeptide-fibril-catalyzes-amyloid-%ce%b2-aggregation-by-promoting-fibril-nucleation-rather-than-direct-axial-growth-by-zhiyuan-song","status":"publish","type":"post","link":"https:\/\/scienceweb.clemson.edu\/gso\/2024\/12\/11\/islet-amyloid-polypeptide-fibril-catalyzes-amyloid-%ce%b2-aggregation-by-promoting-fibril-nucleation-rather-than-direct-axial-growth-by-zhiyuan-song\/","title":{"rendered":"Islet amyloid polypeptide fibril catalyzes amyloid-\u03b2 aggregation by promoting fibril nucleation rather than direct axial growth by Zhiyuan Song"},"content":{"rendered":"<p><span style=\"font-weight: 400\">Zhiyuan<\/span><span style=\"font-weight: 400\"> is a 6th-year graduate student <\/span><span style=\"font-weight: 400\">working with his advisor, <\/span><span style=\"font-weight: 400\">Dr. Feng Ding<\/span><span style=\"font-weight: 400\">, in <\/span><span style=\"font-weight: 400\">Biophysics.. <\/span><span style=\"font-weight: 400\">Check out his\u00a0 paper <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0141813024059439\"><span style=\"font-weight: 400\">here<\/span><\/a><span style=\"font-weight: 400\">.<\/span><\/p>\n<p><span style=\"font-weight: 400\">\u201cProteins like amyloid-beta (A\u03b2) and islet amyloid polypeptide (IAPP) can misfold and form structures called amyloid fibrils, which are linked to diseases like Alzheimer\u2019s (AD) and type 2 diabetes (T2D). We used physics-based molecular dynamics simulations to study how preformed IAPP fibrils interact with A\u03b2, potentially explaining why having T2D increases the risk of AD. We found that IAPP fibrils can speed up A\u03b2 aggregation by providing surfaces that encourage A\u03b2 molecules to bind and form initial clusters, a process called &#8220;cross-seeding.&#8221; However, A\u03b2 and IAPP do not easily form stable hybrid fibrils, meaning their interactions likely involve temporary binding rather than permanent mixing. The study also showed that these interactions depend on where A\u03b2 binds to the IAPP fibril\u2014different surfaces influence how A\u03b2 molecules group together. This research helps explain how diseases like AD and T2D might be biologically connected, offering insights for understanding disease mechanisms and designing new treatments.\u201d<\/span><\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-79 size-full\" title=\"work7\" src=\"https:\/\/scienceweb.clemson.edu\/gso\/wp-content\/uploads\/sites\/44\/2024\/12\/work7.png\" alt=\"work7\" width=\"900\" height=\"400\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zhiyuan is a 6th-year graduate student working with his advisor, Dr. Feng Ding, in Biophysics.. Check out his\u00a0 paper here. \u201cProteins like amyloid-beta (A\u03b2) and islet amyloid polypeptide (IAPP) can misfold and form structures called amyloid fibrils, which are linked to diseases like Alzheimer\u2019s (AD) and type 2 diabetes (T2D). We used physics-based molecular dynamics [&hellip;]<\/p>\n","protected":false},"author":55,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[2],"tags":[],"class_list":["post-98","post","type-post","status-publish","format-standard","hentry","category-graduate-student-works"],"_links":{"self":[{"href":"https:\/\/scienceweb.clemson.edu\/gso\/wp-json\/wp\/v2\/posts\/98","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scienceweb.clemson.edu\/gso\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scienceweb.clemson.edu\/gso\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/gso\/wp-json\/wp\/v2\/users\/55"}],"replies":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/gso\/wp-json\/wp\/v2\/comments?post=98"}],"version-history":[{"count":0,"href":"https:\/\/scienceweb.clemson.edu\/gso\/wp-json\/wp\/v2\/posts\/98\/revisions"}],"wp:attachment":[{"href":"https:\/\/scienceweb.clemson.edu\/gso\/wp-json\/wp\/v2\/media?parent=98"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/gso\/wp-json\/wp\/v2\/categories?post=98"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/gso\/wp-json\/wp\/v2\/tags?post=98"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}