{"id":1505,"date":"2024-11-11T09:07:19","date_gmt":"2024-11-11T14:07:19","guid":{"rendered":"https:\/\/scienceweb.clemson.edu\/epic\/?page_id=1505"},"modified":"2026-01-14T09:33:08","modified_gmt":"2026-01-14T14:33:08","slug":"james-morris","status":"publish","type":"page","link":"https:\/\/scienceweb.clemson.edu\/epic\/about\/people\/james-morris\/","title":{"rendered":"James Morris"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; admin_label=&#8221;row&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_sidebar _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_sidebar][et_pb_image src=&#8221;https:\/\/scienceweb.clemson.edu\/epic\/wp-content\/uploads\/sites\/13\/2024\/11\/jim.jpg&#8221; alt=&#8221;James Morris headshot in lab&#8221; title_text=&#8221;James Morris&#8221; align=&#8221;center&#8221; _builder_version=&#8221;4.27.2&#8243; _module_preset=&#8221;default&#8221; height=&#8221;500px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><strong>Name:<\/strong> James Morris<\/p>\n<p><strong>Title:<\/strong> College of Science Dean\u2019s Distinguished Professor<\/p>\n<p><strong>Department:<\/strong> Genetics and Biochemistry<\/p>\n<p><strong>Email:<\/strong> <a href=\"mailto:jmorri2@clemson.edu\">jmorri2@clemson.edu<\/a><\/p>\n<p><strong>LinkedIn:<\/strong> <a href=\"https:\/\/www.linkedin.com\/in\/james-morris-aa1655261\/\">https:\/\/www.linkedin.com\/in\/james-morris-aa1655261\/<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><strong>Biosketch:<\/strong><br \/>James Morris is currently a Professor of Genetics and Biochemistry at Clemson University.\u00a0 He earned his BS at The College of William and Mary in Williamsburg VA in 1990 and a MS in Entomology at the University of Georgia in Athens GA in 1992.\u00a0 He completed his PhD in Cellular Biology at the University of Georgia in 1997, characterizing the enzymology of a glycosylphosphatidylinositol phospholipase C from the African trypanosome, Trypanosoma brucei, under the supervision of Dr. Kojo Mensa-Wilmot.\u00a0 Following his PhD, Jim moved to Baltimore MD to work in the laboratory of Dr. Paul T. Englund at the Johns Hopkins University School of Medicine, where he was part of the team that developed the first RNAi-based library for forward genetics in any organism \u2013 in this case the African trypanosome.\u00a0 As part of this work, the team developed the vector pZJM (Jim is the \u201cJ\u201d) that is still widely used for silencing genes in the parasite.<\/p>\n<p>In 2003, Jim moved to Clemson University as an Assistant Professor in the Department of Genetics and Biochemistry, where he has remained to date.\u00a0 His team has focused on resolving the mechanisms that protozoan parasites use to sense and metabolize the important sugar glucose during infection of their human host.\u00a0 Through these studies, parasite-specific components of the sugar sensing and uptake pathway have been identified and, in an on-going collaborative effort, small molecule inhibitors of the pathways with anti-parasitic activity have been developed. \u00a0While his team has historically focused on the African trypanosome, more recent work on the malaria parasite Plasmodium falciparum and the brain eating amoeba Naegleria fowleri suggests that exploiting the sugar metabolism pathways of these single-celled invaders may also prove useful in the development of new therapeutics.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Research Summary:<\/strong><br \/>James Morris is a founding member of EPIC.\u00a0 His work focuses on resolving how protozoan parasites sense and metabolize the important sugar glucose during infection of their human host.\u00a0 While his first love is the African trypanosome, he has recently initiated studies on the brain-eating amoeba Naegleria fowleri, a parasite that can be found in the pond that abuts his neighborhood.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Selected Publications:<\/strong><br \/>Complete List of Published Work in My Bibliography: https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/1DuTACUtryjky\/bibliography\/public\/<\/p>\n<ol>\n<li>Palmentiero, CM, McKeon, JEM, Roster, CP,\u00a0<strong>Morris, JC<\/strong>.\u00a0\u00a0Development of approaches for transgene expression in the pathogenic free-living amoeba\u00a0<em>Naegleria fowleri.\u00a0<\/em>(2025),\u00a0<em>Pathogens<\/em>, 15, 12,\u00a0<a href=\"https:\/\/nam12.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fdoi.org%2F10.3390%2Fpathogens15010012&amp;data=05%7C02%7Cnicolec%40clemson.edu%7Cc18431ac8642488e139708de4fbf4f1e%7C0c9bf8f6ccad4b87818d49026938aa97%7C0%7C0%7C639035880238203982%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&amp;sdata=%2B3p0dqY7zCaZ0m6cZZrHikzV%2FCKpsemxf6OL%2BeN2NwA%3D&amp;reserved=0\">https:\/\/doi.org\/10.3390\/pathogens15010012<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<ol start=\"2\">\n<li>Voisinet, MM, Palmentiero, CM, McKeon, JEM, Roster, CP, Carlson, HM, Brzeziniski, TD, Burton, KM, Morris, JC, Mosey, RA.\u00a0\u00a0Development of dihydroquinazoline compounds as novel therapeutics against\u00a0<em>Naegleria fowleri<\/em>. (2025),\u00a0<em>Bioorganic &amp; Medicinal Chemistry Letters\u00a0<\/em>(Accepted).<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<ol start=\"3\">\n<li>Kwain, S, Morris, JDW, Milanes, JE, Roster, CP, Noori, M, Gibbs, AR, Stevenson, RL, McMillen, CD,\u00a0<strong>Morris, JC<\/strong>, Dominy BN, Whitehead, DC. Targeting\u00a0<em>Naegleria fowleri:\u00a0\u00a0<\/em>Assessment of the structure-activity relationship of analogs of the\u00a0<em>Naegleria fowleri<\/em>enolase inhibitor HEX.\u00a0\u00a0(2025),\u00a0<em>RSC Medicinal Chemistry<\/em>,\u00a0<strong>16<\/strong>, 3826 \u2013 3835<em>,<\/em>\u00a0DOI: 10.1039\/d5md00277j<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<ol start=\"4\">\n<li>Call, D, Adjei, JA, Pilgrim, R, Jeong, JW, Willis, EV, Zegarra, RA, Osterhaus, M, Vance, JA, Votyon, CM, Call, JA, Pizarro, S,\u00a0<strong>Morris, JC<\/strong>, Christensen, KA.\u00a0\u00a0A multiplexed high throughput screening assay using flow cytometry identifies glycolytic molecular probes in bloodstream form\u00a0<em>Trypanosoma brucei<\/em><em>.\u00a0\u00a0The International Journal for Parasitology:\u00a0\u00a0Drugs and Drug Resistance\u00a0<\/em>(2024) Dec 26, 100557.\u00a0\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.ijpddr.2024.100557\">https:\/\/doi.org\/10.1016\/j.ijpddr.2024.100557<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<ol start=\"5\">\n<li>Lish, MS, Milanes, JE, Palmentiero, C, Pomeroy, J, Roster, C, Guzei, I,\u00a0<strong>Morris, JC<\/strong>, Golden, JE.\u00a0\u00a0Establishment and optimization of saturated 1,6-naphthyridine-fused quinazolinones that Inhibit meningoencephalitis-causing\u00a0<em>Naegleria fowleri.\u00a0\u00a0Journal of Medicinal Chemistry\u00a0<\/em>(2024) 67 (20):18265-18289.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<ol start=\"6\">\n<li>Milanes, JE, Yan, VC, Pham, C-D, Muller, F, Kwain, S, Rees, KC, Dominy, BN, Whitehead, DC, Millward, SW, Bolejack, M, Abendroth, J, Phan, IQ, Staker, B, Moseman EA, Zhang, X, Xipeng, M, Jebet, A, Yin, X,\u00a0<strong>Morris, JC<\/strong>.\u00a0\u00a0Enolase inhibitors as therapeutic leads for\u00a0<em>Naegleria fowleri<\/em>infection.\u00a0\u00a0<em>PLOS Pathogens\u00a0<\/em>(2024) 20(8): e1012412. <a href=\"https:\/\/doi.org\/10.1371\/journal.ppat.1012412\">https:\/\/doi.org\/10.1371\/journal.ppat.1012412<\/a><\/li>\n<\/ol>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Name: James Morris Title: College of Science Dean\u2019s Distinguished Professor Department: Genetics and Biochemistry Email: jmorri2@clemson.edu LinkedIn: https:\/\/www.linkedin.com\/in\/james-morris-aa1655261\/ &nbsp;Biosketch:James Morris is currently a Professor of Genetics and Biochemistry at Clemson University.\u00a0 He earned his BS at The College of William and Mary in Williamsburg VA in 1990 and a MS in Entomology at the University [&hellip;]<\/p>\n","protected":false},"author":34,"featured_media":0,"parent":1252,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-1505","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/scienceweb.clemson.edu\/epic\/wp-json\/wp\/v2\/pages\/1505","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scienceweb.clemson.edu\/epic\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/scienceweb.clemson.edu\/epic\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/epic\/wp-json\/wp\/v2\/users\/34"}],"replies":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/epic\/wp-json\/wp\/v2\/comments?post=1505"}],"version-history":[{"count":0,"href":"https:\/\/scienceweb.clemson.edu\/epic\/wp-json\/wp\/v2\/pages\/1505\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/epic\/wp-json\/wp\/v2\/pages\/1252"}],"wp:attachment":[{"href":"https:\/\/scienceweb.clemson.edu\/epic\/wp-json\/wp\/v2\/media?parent=1505"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}