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button_one_border_radius__hover=”null” button_two_border_radius__hover_enabled=”off” button_two_border_radius__hover=”null” button_one_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover=”null” button_two_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover=”null” button_one_bg_color__hover_enabled=”on” button_one_bg_color__hover=”rgba(255,255,255,0.8)” button_two_bg_color__hover_enabled=”on” button_two_bg_color__hover=”rgba(255,255,255,0.3)”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ header_font=”|on|||” header_font_size=”48px” header_line_height=”1.2em” background_layout=”dark” custom_padding=”|||” header_font_size_last_edited=”off|desktop” locked=”off” global_colors_info=”{}”]<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_text_color=”#FFFFFF” global_colors_info=”{}”]To learn more about individual staff members, please click on the links below.
\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”|on|on” admin_label=”Hero” _builder_version=”4.16″ background_color=”#8300e9″ use_background_color_gradient=”on” background_color_gradient_stops=”rgba(71,74,182,0.27) 0%|#322e66 100%” background_color_gradient_start=”rgba(71,74,182,0.27)” background_color_gradient_end=”#322e66″ background_position=”top_center” background_blend=”overlay” custom_margin=”||60px” custom_padding=”10px|0px|10px|0px” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”2%” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”1280px” global_colors_info=”{}” button_one_text_size__hover_enabled=”off” button_one_text_size__hover=”null” button_two_text_size__hover_enabled=”off” button_two_text_size__hover=”null” button_one_text_color__hover_enabled=”on” button_one_text_color__hover=”#3550a0″ button_two_text_color__hover_enabled=”on” button_two_text_color__hover=”#ffffff” button_one_border_width__hover_enabled=”off” button_one_border_width__hover=”null” button_two_border_width__hover_enabled=”off” button_two_border_width__hover=”null” button_one_border_color__hover_enabled=”off” button_one_border_color__hover=”null” button_two_border_color__hover_enabled=”off” button_two_border_color__hover=”null” button_one_border_radius__hover_enabled=”off” button_one_border_radius__hover=”null” button_two_border_radius__hover_enabled=”off” button_two_border_radius__hover=”null” button_one_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover=”null” button_two_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover=”null” button_one_bg_color__hover_enabled=”on” button_one_bg_color__hover=”rgba(255,255,255,0.8)” button_two_bg_color__hover_enabled=”on” button_two_bg_color__hover=”rgba(255,255,255,0.3)”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.6″ text_font_size=”26px” text_line_height=”1.2em” header_font=”|on|||” header_font_size=”26px” header_line_height=”1.2em” background_layout=”dark” custom_padding=”|||” hover_enabled=”0″ header_font_size_last_edited=”off|desktop” locked=”off” global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” text_text_color=”#FFFFFF” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
To learn more about individual staff members, please click on the links below.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.20.2″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.20.2″ _module_preset=”default” custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.20.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_accordion toggle_icon=”?||divi||400″ _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” toggle_level=”h2″ toggle_font=”|700|||||||” sticky_enabled=”0″ body_text_color=”#000000″][et_pb_accordion_item title=”Faculty” open=”on” _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
The EPIC faculty is a team of dedicated researchers with interests that range from understanding mechanisms of drug resistance in fungal pathogens to fatty acid metabolism in kinetoplastid parasites. We are united in our focus on some of the world’s most troubling and neglected disease-causing organisms.<\/p>\n
Christopher Chouinard<\/strong><\/a> Sourabh Dhingra<\/strong><\/a> Stephen Dolan<\/strong><\/a> Zhicheng Dou<\/strong><\/a> Manuel Fierro<\/a><\/strong> Cheryl Ingram-Smith<\/strong><\/a> Andrew Jezewski<\/a><\/strong> Lukasz Kozubowski<\/strong><\/a> Jessica Larsen<\/a><\/strong> James Lewis<\/a><\/strong> Rodrigo Martinez-Duarte<\/strong><\/a> Meredith Morris<\/strong><\/a> James Morris<\/strong><\/a> Kim Paul<\/strong><\/a> Erica Porter<\/a><\/strong> Emily Rosowski<\/strong><\/a> Anna Seekatz<\/strong><\/a> Michael Sehorn<\/strong><\/a> Kerry Smith – EPIC Director<\/strong><\/a> Alexis Stamatikos<\/a><\/strong> Lesly Temesvari<\/strong><\/a> Alexey Vertegel<\/strong><\/a> Katelyn Walzer<\/strong><\/a> Daniel Whitehead<\/strong><\/a> [\/et_pb_accordion_item][et_pb_accordion_item title=”Staff and Research Associates” _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” open=”off” sticky_enabled=”0″]<\/p>\n The staff and research associates make EPIC tick. They keep the labs working and push their own projects forward while serving as mentors to the many students that fill EPIC\u2019s research space.<\/p>\n Dr. Akhila Pudipeddi<\/strong><\/a><\/p>\n Postdoctoral Fellow, Dou Lab<\/p>\n Annika Nelson<\/strong><\/a><\/p>\n Lab Technician, Dou Lab<\/p>\n Bruce Rafert<\/strong><\/a><\/p>\n Director, EPIC Initiatives<\/p>\n Professor and Graduate Dean Emeritus<\/p>\n Dr. Jillian (Milanes) McKeon<\/strong><\/a><\/p>\n Postdoctoral Fellow, J. Morris Lab<\/p>\n Jack Forster<\/strong><\/a><\/p>\n Lab Technician, Walzer Lab<\/p>\n Jessica Keeran<\/strong><\/a><\/p>\n Lab Manager, Kozubowski Lab<\/p>\n Jonathan Stortz<\/strong><\/a><\/p>\n Lab Technician, Fierro Lab<\/p>\n Michael Kellett<\/strong><\/a><\/p>\n Lab Technician, Seekatz Lab\u00a0<\/p>\n Dr. Nava Poudyal<\/strong><\/a><\/p>\n Postdoctoral Fellow, Dhingra Lab\u00a0<\/p>\n Nicki Clark-Mount<\/strong><\/a><\/p>\n EPIC COBRE Project Coordinator<\/p>\n Riddhi Patel<\/strong><\/a><\/p>\n Lab Technician, Fierro Lab\u00a0<\/p>\n Dr. Sophie Millard<\/strong><\/a><\/p>\n Postdoctoral Fellow, Seekatz Lab<\/p>\n Tabitha Varnell<\/strong><\/a><\/p>\n Lab Technician, Dou Lab<\/p>\n [\/et_pb_accordion_item][et_pb_accordion_item title=”Graduate Students” _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” open=”off” sticky_enabled=”0″]<\/p>\n Students, both graduate and undergraduate, tackle experiments necessary to solve the tough questions that exist in the field of eukaryotic pathogens research. They are the driving force in the center.\u00a0<\/p>\n Alessandro Rocchi<\/a><\/strong> Amy Bergmann<\/a><\/strong> Antonia Blank<\/a><\/strong> Baker Garrison<\/a><\/strong> Caroline Palmentiero<\/a><\/strong> Clara Flores<\/a><\/strong> Colm Roster<\/a><\/strong> Hanna Akahoho<\/a><\/strong> Heidi Sabatini<\/a><\/strong> Jude Sulieman<\/a><\/strong> Juliana Bobo<\/a><\/strong> Justin Leonhardt<\/a><\/strong> Laura Jacob<\/a><\/strong> Lauren Mitchel<\/a><\/strong> Marilize Cornwell<\/a><\/strong> Meagan Seesengood<\/a><\/strong> Melanie Howe<\/a><\/strong> Pinaki Ghosh<\/a><\/strong> Shivam Yadav<\/a><\/strong> Shivani Kore<\/a><\/strong> Solomon Ngwira<\/a><\/strong> Tejas Patel<\/a><\/strong>
Chemistry<\/em>
Our group focuses on the development of mass spectrometry technology and methods to better characterize complex systems (i.e., the metabolome) in eukaryotic pathogenesis and other chemical\/biological\/forensic applications. Specific projects include design of novel high-resolution ion mobility-mass spectrometry (HRIM-MS) techniques, targeted chemical probes for structure elucidation and quantification, and mass spectrometry imaging (MSI) for spatial metabolomics<\/p>\n
Biological Sciences<\/em>
The overarching goal of the Dhingra lab is to understand the molecular mechanisms associated with pathogenesis and azole drug tolerance in invasive pulmonary aspergillosis. We use molecular, biochemical and cellular approaches as well as murine models to understand the role of ncRNAs in pathobiology and azole drug tolerance of Aspergillus fumigatus<\/em>.<\/span><\/p>\n
Genetics and Biochemistry<\/em>
I study microbial interactions in human infections, specifically complex communities formed by multiple species, resulting in polymicrobial infections. My primary research focus is on respiratory infections in individuals with cystic fibrosis (CF), where the abnormal mucus makes them susceptible to various bacterial, viral, and fungal pathogens. Instead of studying a single model organism, I intentionally pursued broad training on multiple co-infecting human pathogens (notably\u00a0Aspergillus <\/em>and Pseudomonas<\/em>). This comprehensive, multisystem approach allows us to unravel the intricate mechanisms of communication between microbes during infection.
Linkedin<\/a><\/span><\/p>\n
Biological Sciences<\/em>
Our research group focuses on unraveling the complex mechanisms by which Toxoplasma gondii<\/em> acquires and utilizes nutrients to sustain intracellular replication, aiming to identify potential targets within the parasite’s nutrient metabolism pathways for novel drug development. Additionally, we seek to deepen the understanding of subcellular processes involved in the pathogenesis of Histomonas<\/em> parasites. Our efforts also extend to investigating and characterizing the transmissible form of Histomonas<\/em> that facilitates the spread of infection among turkey flocks.<\/span><\/p>\n
Genetics and Biochemistry<\/em>
Our lab is interested in studying the biology of Plasmodium to identify novel points of attack that can lead to novel antimalarial or vaccine development. We use a wide range of functional and reverse genetic approaches and employ novel molecular tool development to understand the host-pathogen interactions present during blood-stage infection of Plasmodium falciparum by characterizing the essential process of host-cell remodeling.<\/p>\n
Genetics and Biochemistry<\/em>
The interests of the lab include the transcriptional, proteomic, and metabolic changes that occur during encystation and excystation in Entamoeba histolytica<\/em>.<\/span><\/p>\n
Genetics and Biochemistry<\/em>
Identifying and characterizing the virulence required mechanisms of Cryptococcus neoformans.<\/p>\n
Genetics and Biochemistry<\/em>
Our lab studies how cell division and stress response mechanisms intersect and contribute to fungal pathogenicity. To address our questions we utilize Cryptococcus neoformans, an encapsulated, opportunistic fungal pathogen that causes severe, often fatal, infections, primarily pulmonary and central nervous system meningitis in immunocompromised individuals, especially those with AIDS.<\/span><\/p>\n
Chemical and Biomolecular Engineering<\/em>
We develop nanoparticle tools that respond to pathologic stimuli to deliver drugs across biologic nervous system barriers including the blood-brain barrier and the blood-nerve barrier.<\/span><\/p>\n
Genetics and Biochemistry<\/em>
My research goal is to understand how populations adapt to novel selection pressures, focusing on: 1) What are the molecular mechanisms and changes that produce novel adaptive phenotypes?, 2) How do these mechanisms evolve?, and 3) How does adaptive change dictate subsequent evolution within and between populations?<\/p>\n
School of Mechanical and Automotive Engineering<\/em><\/p>\n\n
Genetics and Biochemistry<\/em>
Research in the Morris laboratory focuses on the cell biology of parasitic protozoa, using Trypanosoma brucei as a model system to understand how subcellular organization and post-translational regulation shape parasite metabolism and survival.
In parallel, the lab investigates SET domain protein lysine methyltransferases and their roles in regulating non-histone proteins involved in metabolism and organelle function.<\/span><\/p>\n
Genetics and Biochemistry<\/em>
James Morris is a founding member of EPIC.\u00a0 His work focuses on resolving how protozoan parasites sense and metabolize the important sugar glucose during infection of their human host.\u00a0 While his first love is the African trypanosome, he has recently initiated studies on the brain-eating amoeba Naegleria fowleri, a parasite that can be found in the pond that abuts his neighborhood.<\/span><\/p>\n
Genetics and Biochemistry<\/em>
I am interested in fatty acid metabolism in Trypanosoma brucei and its distantly related cousin, Crithidia fasciculata, specifically the regulation of the balance between de novo synthesis and uptake from the host. I also am interested in the history of tropical medicine, specifically the role of Lady Elizabeth Bruce in the scientific discoveries of her husband, Sir David Bruce. I am also interested in pedogogical approaches to scientific writing.<\/span><\/p>\n
Math and Statistical Sciences<\/em> (LinkedIn<\/a>)<\/span><\/p>\n
Biological Sciences<\/em>
My lab focuses on understanding host-pathogen interactions, using the larval zebrafish as a model host. We are currently studying how innate immune mechanisms control infections with the fungus Aspergillus fumigatus<\/em>.<\/span><\/p>\n
Biological Sciences<\/em><\/span><\/p>\n\n
Infectious diseases; Clostridioides difficile; Klebsiella pneumoniae; Trichuris muris<\/span><\/li>\n<\/ul>\n
Genetics and Biochemistry<\/em>
My laboratory strives to understand the mechanism of homology-directed repair of DNA double-strand breaks mediated by RAD51 and DMC1 in Saccharomyces cerevisiae<\/em>, Entamoeba histolytica<\/em> and humans.
Linkedin<\/a><\/span><\/p>\n
Genetics and Biochemistry<\/em>
My group is interested in the acetate metabolism in the fungal pathogen Cryptococcus<\/em>.
Linkedin<\/a><\/span><\/p>\n
Food, Nutrition, and Packaging Sciences<\/em>
Exploring the role of TLR-mediated immune responses in kinetoplastid parasite infections.<\/span><\/p>\n
Biological Sciences<\/em>
The overall goal of the Temesvari laboratory is to understand the molecular mechanisms regulating a virulence in several pathogenic amoebae, Entamoeba histolytica and Acanthamoeba castellanii. These parasites causes amoebic dysentery and liver abscess) and keratitis, respectively. The Temesvari laboratory focuses on parasite-host interactions, the stress response in the parasite, vesicle trafficking, lipid rafts and drug-repurposing.<\/span><\/p>\n
Bioengineering<\/em>
My research interests are in the area of antimicrobial and antioxidant treatments and coatings. My current research portfolio includes projects on the development of natural long-lasting disinfectant, antimicrobial and immune suppressing coatings on surgical implants such Kirschner\u2019s wires and hernia repair meshes, and development of anti-Clostridium natural hand sanitizer. We also work on the development of chitosan-based antifungal agents for agricultural applications.<\/span><\/p>\n
Biological Sciences<\/em>
Our lab studies gene regulation, expression, and function across the Cryptosporidium<\/em> life cycle. We currently focus on male and female development as sexual reproduction is required for continuous infection and transmission of the parasite. We utilize both cell culture and mouse models of infection.<\/span><\/p>\n
Chemistry<\/em>
EPIC-related projects in the Whitehead lab focus on the synthesis of small molecules and conjugates for the development of therapeutic and drug delivery strategies for treating eukaryotic pathogen infections.
Linkedin<\/a><\/span><\/p>\n
Graduate Student, Dou Lab<\/p>\n
Graduate Student, Temesvari Lab<\/p>\n
Graduate Student, Fierro Lab<\/p>\n
Graduate Student, Chouinard Lab\u00a0<\/p>\n
Graduate Student, J. Morris Lab\u00a0<\/p>\n
Graduate Student, Seekatz Lab<\/p>\n
Graduate Student, J. Morris Lab<\/p>\n
Graduate Student, Kozubowski Lab<\/p>\n
Graduate Student, Chouinard Lab<\/p>\n
Graduate Student, Chouinard Lab<\/p>\n
Graduate Student, Kozubowski Lab<\/p>\n
Graduate Student, Kozubowski Lab<\/p>\n
Graduate Student, Dou Lab<\/p>\n
Graduate Student, M. Morris Lab\u00a0<\/p>\n
Graduate Student, Seekatz Lab<\/p>\n
Graduate Student, Seekatz Lab<\/p>\n
Graduate Student, Martinez-Duarte Lab<\/p>\n
Graduate Student, Dhingra Lab<\/p>\n
Graduate Student, PI Lab\u00a0<\/p>\n
Graduate Student, Dou Lab<\/p>\n
Graduate Student, Fierro Lab\u00a0<\/p>\n
Graduate Student, Kozubowski Lab<\/p>\n