[et_pb_section fb_built=”1″ admin_label=”Hero” _builder_version=”4.16″ background_color=”RGBA(0,0,0,0)” use_background_color_gradient=”on” background_color_gradient_direction=”91deg” background_color_gradient_stops=”rgba(82,45,128,0.85) 63%|rgba(0,0,0,0.51) 90%” background_color_gradient_overlays_image=”on” background_color_gradient_start=”rgba(82,45,128,0.85)” background_color_gradient_start_position=”63%” background_color_gradient_end=”rgba(0,0,0,0.51)” background_color_gradient_end_position=”90%” background_image=”https:\/\/scienceweb.clemson.edu\/cobre\/wp-content\/uploads\/sites\/14\/2021\/04\/genetic2.jpg” custom_margin=”||||false|false” custom_padding=”133px|0px|134px|0px||” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”2%” hover_enabled=”0″ background_last_edited=”on|phone” background_color_gradient_stops_phone=”rgba(82,45,128,0.85) 100%|rgba(0,0,0,0.51) 100%” background_color_gradient_start_position_phone=”100%” locked=”off” global_colors_info=”{}” sticky_enabled=”0″][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”|||” custom_width_px=”1280px” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ header_font=”|on|||” header_font_size=”44px” header_line_height=”1.3em” background_layout=”dark” custom_margin=”||||false|false” custom_padding=”||||false|false” header_font_size_tablet=”” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.16″ text_text_color=”#ffffff” text_font_size=”20px” text_line_height=”1.5em” custom_padding=”||3px|||” locked=”off” global_colors_info=”{}”]<\/p>\n
The Clemson University Institute for Human Genetics and the Greenwood Genetic Center have been awarded a five-year Phase I COBRE in Human Genetics grant to understand the genetic, genomic and epigenetic mechanisms by which molecular genetic variation affects transcriptional and other molecular networks in health and disease.<\/p>\n
[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”100px||100px|||” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ text_text_color=”#2e1a47″ header_font=”||||||||” header_text_color=”#2e1a47″ header_font_size=”26px” header_2_font=”|700|||||||” header_2_text_color=”#2e1a47″ header_2_font_size=”42px” header_2_line_height=”1.3em” width=”100%” custom_margin=”|-25px|20px|||” custom_padding=”|0px||||” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”10%” locked=”off” global_colors_info=”{}” header_font_size__hover=”30px” header_font_size__hover_enabled=”30px” header_letter_spacing__hover=”0px” header_letter_spacing__hover_enabled=”0px” header_text_shadow_style__hover=”none” header_text_shadow_style__hover_enabled=”none” header_text_shadow_color__hover=”rgba(0,0,0,0.4)” header_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)”]<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” text_font=”||||||||” text_font_size=”16px” text_line_height=”1.6em” custom_margin=”|-5px||||” global_colors_info=”{}”]<\/p>\n
Common and rare genetic diseases affect a large fraction of the world\u2019s population. Elucidating the mechanisms by which naturally occurring genetic variants affect disease risk requires multidisciplinary expertise in quantitative, population, molecular, cellular and developmental genetics; statistics, bioinformatics and computational biology; and functional genomics in cell culture and animal models. The Center of Biomedical Research Excellence (COBRE) in Human Genetics constitutes a unique partnership between the Clemson University Institute for Human Genetics<\/a> and the Greenwood Genetic Center<\/a>. Research in the COBRE in Human Genetics focuses on understanding the genetic, genomic, and epigenetic mechanisms by which molecular genetic variation affects rare and common diseases. The COBRE in Human Genetics supports four research projects from junior investigators that tackle several of the outstanding challenges facing modern human genetics, including the roles of human long non-coding RNAs in risk for human disease, the effects of structural variation on disease phenotypes and gene regulation, development of animal models for rare diseases, and incorporating context-dependent effects into statistical models predicting complex trait phenotypes from large-scale genetic variation data. The research performed by the project leaders of the COBRE in Human Genetics will provide new knowledge of the mechanisms by which molecular genetic variation affects variation in complex traits in health and disease.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/scienceweb.clemson.edu\/cobre\/wp-content\/uploads\/sites\/14\/2025\/06\/front.jpg” alt=”A one-story building with glass walls, a slanted roof, and a sign that says, %22Self Regional Hall%22.” title_text=”front” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”1px||4px|||” custom_padding=”2px|||||” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” custom_padding=”0px||0px|||” global_colors_info=”{}”]<\/p>\n Clemson University Institute for Human Genetics<\/p>\n [\/et_pb_text][et_pb_image src=”https:\/\/scienceweb.clemson.edu\/cobre\/wp-content\/uploads\/sites\/14\/2025\/06\/GGC.jpg” alt=”A photo of a large, L-shaped brick building with lit windows taken from across the asphalt.” title_text=”GGC” _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”1px||3px|||” custom_padding=”0px|||||” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n Greenwood Genetic Center<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Footer” _builder_version=”4.16″ background_color=”#f7f8fc” custom_padding=”55px|0px|54px|0px||” animation_style=”zoom” animation_direction=”bottom” animation_intensity_zoom=”6%” animation_starting_opacity=”100%” saved_tabs=”all” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_4,1_4″ use_custom_gutter=”on” gutter_width=”2″ _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ header_font=”||||||||” header_2_font=”|700|||||||” header_2_text_color=”#2e1a47″ header_2_font_size=”36px” header_2_line_height=”1.3em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”||-1px|||” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”10%” global_colors_info=”{}” header_font_size__hover=”30px” header_font_size__hover_enabled=”30px” header_letter_spacing__hover=”0px” header_letter_spacing__hover_enabled=”0px” header_text_shadow_style__hover=”none” header_text_shadow_style__hover_enabled=”none” header_text_shadow_color__hover=”rgba(0,0,0,0.4)” header_text_shadow_color__hover_enabled=”rgba(0,0,0,0.4)”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.4″ text_text_color=”#333333″ text_font_size=”22px” text_line_height=”1.9em” background_size=”initial” background_position=”top_left” background_repeat=”repeat” animation_style=”fade” locked=”off” global_colors_info=”{}”]<\/p>\n Reach out to us today to explore how you can contribute to our efforts and benefit from our state-of-the-art facilities and expert teams.<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_button button_url=”https:\/\/scienceweb.clemson.edu\/cobre\/contact\/” button_text=”Contact Us” button_alignment=”left” _builder_version=”4.27.4″ custom_button=”on” button_text_size=”16px” button_text_color=”#FFFFFF” button_bg_color=”#522d80″ button_border_width=”10px” button_border_color=”RGBA(255,255,255,0)” button_border_radius=”100px” button_letter_spacing=”1px” button_font=”|on||on|” button_icon=”E||divi||400″ button_on_hover=”off” custom_margin=”19px|||||” animation_style=”zoom” animation_delay=”100ms” animation_intensity_zoom=”6%” box_shadow_style=”preset1″ box_shadow_vertical=”10px” box_shadow_blur=”50px” box_shadow_spread=”5px” box_shadow_color=”rgba(114,114,255,0.4)” button_letter_spacing_hover=”2px” locked=”off” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”2px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Center of Biomedical Research Excellence (COBRE) in Human GeneticsThe Clemson University Institute for Human Genetics and the Greenwood Genetic Center have been awarded a five-year Phase I COBRE in Human Genetics grant to understand the genetic, genomic and epigenetic mechanisms by which molecular genetic variation affects transcriptional and other molecular networks in health and disease.The […]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-947","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/scienceweb.clemson.edu\/cobre\/wp-json\/wp\/v2\/pages\/947","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scienceweb.clemson.edu\/cobre\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/scienceweb.clemson.edu\/cobre\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/cobre\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/scienceweb.clemson.edu\/cobre\/wp-json\/wp\/v2\/comments?post=947"}],"version-history":[{"count":0,"href":"https:\/\/scienceweb.clemson.edu\/cobre\/wp-json\/wp\/v2\/pages\/947\/revisions"}],"wp:attachment":[{"href":"https:\/\/scienceweb.clemson.edu\/cobre\/wp-json\/wp\/v2\/media?parent=947"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Join Us in Advancing Research<\/h2>\n