864-889-0519 chg@clemson.edu

Graduate Student

Email: afroidc@g.clemson.edu

Biosketchalec froidcoeur

Originating from Troy, Illinois, I graduated from North Central College with a B.S. in Biochemistry in December of 2020.  During my undergraduate studies, I worked on a few independent research projects such as designing a fluoride ion acceptor to increase the longevity of lithium-ion batteries and investigating an immune response to West Nile virus.  After briefly working as a quality control technician, I started my PhD in Biochemistry in Dr. Andrei Alexandrov’s lab at the Clemson Center for Human Genetics in the Fall of 2021.

Research

My graduate research will be focused on forward genetics-based identification of regulatory circuits of human disease-associated long non-coding RNAs (lncRNAs). Currently, I am cloning key regulatory regions of several human lncRNAs into the Mirror reporter system. I will then construct stable reporter cell lines and use customized CRISPR (omission) sgRNA libraries to screen for components of human pathways acting on these lncRNAs. I will then proceed to validation of screening-identified genes, determining molecular roles of their respective RNA/protein products, and assessment of their potential as therapeutic targets.